AAC Accepts, published online ahead of print on 14 May 2007
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00231-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

LACK OF AN EFFECT OF ANTIBIOTIC TREATMENT ON PROLONGED DETECTION OF CHLAMYDIAL DNA IN MURINE GENITAL TRACT INFECTION

Dawn M. Reeves, Uma Nagarajan, Catherine O'Connell, Charles W. Andrews Jr., and Toni Darville*

Department of Pediatric Infectious Disease and Microbiology and Immunology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Rockdale Pathology Partners, Atlanta, Georgia

* To whom correspondence should be addressed. Email: darvilletonil{at}uams.edu.


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Abstract

Mice treated early with antibiotic or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. Early eradication of infection limited oviduct pathology, despite continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability to detect DNA or oviduct pathology.






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