AAC Accepts, published online ahead of print on 2 July 2007
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00362-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action

Emily S. Pfeiffer and Hiroshi Hiasa*

Department of Pharmacology, University of Minnesota Medical School - Twin Cities, Minneapolis, Minnesota 55455

* To whom correspondence should be addressed. Email: hiasa001{at}umn.edu.


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Abstract

We employed an assay to measure quinolone sensitivity as a shift in the position of the cleavage-religation equilibrium. This assay was found to be useful in identifying the primary target of a quinolone drug and assessing the effect of quinolone resistance-conferring mutations.






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