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Antimicrob. Agents Chemother. doi:10.1128/AAC.00393-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Calcineurin Promotes Infection of the Cornea by Candida albicans and can be Targeted to Enhance Fluconazole Therapy

Departments of Molecular Genetics and Microbiology, Medicine, and Pharmacology and Cancer Biology, and Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 27710

^* To whom correspondence should be addressed. Email: afsha003{at}mc.duke.edu, heitm001{at}duke.edu.

	Abstract

In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

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