AAC Accepts, published online ahead of print on 10 September 2007
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00416-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Lack of Correlation Between embB Mutation and Ethambutol Minimal Inhibitory Concentration in Mycobacterium tuberculosis Clinical Isolates from China

Ruiru Shi, Jianyuan Zhang, Koji Otomo, Guolong Zhang, and Isamu Sugawara*

Mycobacterial Reference Center, The Research Institute of Tuberculosis, Tokyo, Japan; Henan Provincial Chest Hospital, Zhengzhou, China; and Beijing Tuberculosis and Lung Tumor Research Institute, Beijing, China

* To whom correspondence should be addressed. Email: sugawara{at}jata.or.jp.


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Abstract

Seventy-four Mycobacterium tuberculosis clinical isolates from China were subjected to drug susceptibility testing using ethambutol, isoniazid, rifampicin, and ofloxacin. The results revealed that embB mutation did not correlate with ethambutol resistance but was associated with multiple-drug resistance, especially resistance to rifampicin.




This article has been cited by other articles:

  • Starks, A. M., Gumusboga, A., Plikaytis, B. B., Shinnick, T. M., Posey, J. E. (2009). Mutations at embB Codon 306 Are an Important Molecular Indicator of Ethambutol Resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 53: 1061-1066 [Abstract] [Full Text]  
  • Safi, H., Sayers, B., Hazbon, M. H., Alland, D. (2008). Transfer of embB Codon 306 Mutations into Clinical Mycobacterium tuberculosis Strains Alters Susceptibility to Ethambutol, Isoniazid, and Rifampin. Antimicrob. Agents Chemother. 52: 2027-2034 [Abstract] [Full Text]  


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