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AAC Accepts, published online ahead of print on 9 July 2007
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00473-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Haemophilus ducreyi is Resistant to Human Antimicrobial Peptides

Kristy L. B. Mount, Carisa A. Townsend, and Margaret E. Bauer*

Department of Microbiology and Immunology, Indiana University School of Medicine

* To whom correspondence should be addressed. Email: mebauer{at}iupui.edu.


   Abstract

We examined the susceptibility of Haemophilus ducreyi to antimicrobial peptides likely to be encountered in vivo during human infection. H. ducreyi was significantly more resistant than Escherichia coli to the bactericidal effects of all peptides tested. Class I and II H. ducreyi strains exhibited similar levels of antimicrobial peptide resistance.







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