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Antimicrob. Agents Chemother. doi:10.1128/AAC.00485-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

EFFICACY OF CASPOFUNGIN AGAINST Aspergillus flavus, Aspergillus terreus, AND Aspergillus nidulans

Departments of Infectious Disease and Biometrics Research, Merck Research Laboratories, Rahway, NJ 07065-0900

^* To whom correspondence should be addressed. Email: joel_bowman{at}merck.com,

	Abstract

The echinocandin caspofungin is a potent inhibitor of 1,3--D-glucan synthase activity from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated infection, caspofungin prolonged survival and reduced kidney burden. Caspofungin was at least as effective as amphotericin B against these filamentous fungi in vivo.

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