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Antimicrob. Agents Chemother. doi:10.1128/AAC.00492-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Targeting the Calcineurin Pathway Enhances Ergosterol Biosynthesis Inhibitors Against Trichophyton mentagrophytes in vitro and in a Human Skin Infection Model

Departments of Molecular Genetics and Microbiology, Medicine, and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710; Department of Plastic Surgery, Rambam Medical Center, Haifa, Israel; Faculty of Medicine, Molecular Microbiology, and Biology, Technion – Israel Institute of Technology, Haifa, Israel

^* To whom correspondence should be addressed. Email: israelab{at}tx.technion.ac.il. heitm001{at}duke.edu.

	Abstract

Fluconazole-FK506/CsA drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by SEM over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations.

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