AAC Accepts, published online ahead of print on 14 July 2008
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00553-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

In vitro and in vivo treatment of Echinococcus protoscoleces and metacestodes with artemisinin and artemisinin-derivatives

Martin Spicher*, Carole Roethlisberger, Catharina Lany, Britta Stadelmann, Jennifer Keiser, Luis M. Ortega-Mora, Bruno Gottstein, and Andrew Hemphill*

Institute of Parasitology, Vetsuisse Faculty, University of Berne, Länggass-Strasse 122, CH-3012 Berne, Switzerland; Institute of Animal Pathology, Vetsuisse Faculty, University of Berne, Länggass-Strasse 122, CH-3012 Berne, Switzerland; Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, PO Box, CH-4002 Basel, Switzerland; Grupo SALUVET, Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain

* To whom correspondence should be addressed. Email: martin.spicher{at}ipa.unibe.ch. andrew.emphill{at}ipa.unibe.ch.


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Abstract

In vitro treatment of E. multilocularis and E. granulosus larval stages with the anti-malarials dihydroartemisinin (DHA) and artesunate (10-40 µM) exhibited, while 6 weeks in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg/day) had no effect. However, combination treatments of both drugs with albendazole lead to a substantial, but statistically not significant, reduction in parasite weight compared to albendazole alone.






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