AAC Accepts, published online ahead of print on 14 July 2008

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Antimicrob. Agents Chemother. doi:10.1128/AAC.00562-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Antimalarial activity of a new stilbene glycoside from Parthenocissus tricuspidata in mice

Won-Hwan Park, Sung Jae Lee, and Hyung-In Moon^*

Department of Diagnostics and Cardiovascular Medical Research Center, College of Korean Medicine, Dongguk University, Gyeong-Ju 780-714, South Korea; Department of Integrative Medicine, College of Medicine, Korea University, Anam-dong 5ga, Seongbuk-gu, Seoul 136-705, South Korea; Department of Neurology and Inam Neuro Science Research Center, Wonkwang University Sanbon Medical Center, Kyunggi-Do 435-040, South Korea

^* To whom correspondence should be addressed. Email: himoon{at}wonkwang.ac.kr.

A novel stilbene glycoside (piceid-(16)--d-glucopyranoside; PBG) from Parthenocissus tricuspidata was tested in vivo against Plasmodium berghei. PBG exhibited significant blood schizontocidal activity in 4-d early infection, repository evaluation, and established infection, with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg·kg^-1·d^-1).