This Article Full Text (PDF) Other Versions of this Article: AAC.00612-07v1 52/1/198    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Adonizio, A. Articles by Mathee, K. Search for Related Content PubMed PubMed Citation Articles by Adonizio, A. Articles by Mathee, K.

 Previous Article  |  Next Article 

Antimicrob. Agents Chemother. doi:10.1128/AAC.00612-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts

Department of Biological Sciences, Florida International University, Miami, FL 33199, USA

^* To whom correspondence should be addressed. Email: matheek{at}fiu.edu.

	Abstract

Quorum sensing (QS) is a key regulator of virulence and biofilm formation in Pseudomonas aeruginosa and other medically relavent bacteria. Aqueous extracts of six plants: Conocarpus erectus, Chamaesyce hypericifolia, Callistemon viminalis, Bucida buceras, Tetrazygia bicolor, and Quercus virginiana were examined in this study for their effects on P. aeruginosa virulence factors and the QS system. C. erectus, B. buceras, and C. viminalis cause significant inhibition of LasA protease, LasB elastase, pyoverdin production, and biofilm formation. Additionally, each plant presents a distinct profile of effect on the las and rhl QS genes and their respective signaling molecules, suggesting different mechanisms responsible for efficacy. Extracts of all plants caused inhibition of QS genes and QS-controlled factors with marginal effects on bacterial growth, suggesting quorum quenching mechanisms unrelated to static or cidal effects.

This article has been cited by other articles:

• Adonizio, A., Leal, S. M. Jr, Ausubel, F. M., Mathee, K. (2008). Attenuation of Pseudomonas aeruginosa virulence by medicinal plants in a Caenorhabditis elegans model system. J Med Microbiol 57: 809-813 [Abstract] [Full Text]