AAC Accepts, published online ahead of print on 28 August 2006
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00616-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Synergy between the Efflux Pump CmeABC and Modifications in Ribosomal Proteins L4 and L22 in Conferring Macrolide Resistance in Campylobacter jejuni and C. coli

Cédric Cagliero, Christian Mouline, Axel Cloeckaert, and Sophie Payot*

Institut National de la Recherche Agronomique, UR1282 Infectiologie Animale et Santé Publique (IASP-213), 37380 Nouzilly, France

* To whom correspondence should be addressed. Email: payot{at}tours.inra.fr.


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Abstract

Macrolide-resistant mutants of Campylobacter jejuni and C. coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conferring macrolide resistance was observed.




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