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Antimicrob. Agents Chemother. doi:10.1128/AAC.00711-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

No genetic bottle-neck in Plasmodium falciparum wild type pfcrt alleles re-emerging in Hainan Island, China following high-level chloroquine resistance

Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Enoggera, Queensland Australia; Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, People's Republic of China; Hainan Provincial Center for Disease Control and Prevention, Haikou, Hainan, People's Republic of China and Malaria Drug Resistance and Diagnostics, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

^* To whom correspondence should be addressed. Email: qin.cheng{at}defence.gov.au.

	Abstract

Chloroquine resistant P. falciparum was highly prevalent in Hainan, China in the 1970s. Twenty-five years after cessation of chloroquine therapy the prevalence of P. falciparum wild type pfcrt alleles has risen to 36% (95% CI: 22.1-52.4%). The diverse origins of wild-type alleles indicate there was no genetic bottle-neck caused by high chloroquine resistance.