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AAC Accepts, published online ahead of print on 15 October 2007
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AAC.00726-07v1
51/12/4466    most recent
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00726-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

"Complex class 1 integrons with diverse variable regions including aac(6')-Ib-cr and a novel allele qnrB10 associated to ISCR1 in clinical enterobacteria from Argentina"

María Paula Quiroga, Patricia Andres, Alejandro Petroni, Alfonso Soler-Bistué, Leonor Guerriero, Liliana Jordá Vargas, Angeles Zorreguieta, Marta Tokumoto, Cecilia Quiroga, Marcelo Tolmasky, Marcelo Galas, and Daniela Centrón*

Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires; Servicio Antimicrobianos, Departamento de Bacteriología, Instituto Nacional de Enfermedades Infecciosas – ANLIS "Dr. Carlos G. Malbrán", Buenos Aires; Fundación Instituto Leloir, CONICET, FCEyN, Universidad de Buenos Aires, Buenos Aires; Instituto de Cardiología y Cirugía Cardiovascular (ICYCC) "Fundación Favaloro", Buenos Aires, Argentina; and California State University Fullerton, Fullerton, California

* To whom correspondence should be addressed. Email: dcentron{at}gmail.com.


   Abstract

Transferable quinolone resistance was not reported yet in Argentina. Here, we describe three complex class 1 integrons harbouring the novel allele qnrB10 in a unique region downstream to orf513, one of them also containing aac(6')-Ib-cr within the variable region of integrons. The three arrays differed from blaCTX-M-2-bearing integrons, which are broadly spread in Argentina.




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