AAC Accepts, published online ahead of print on 14 April 2008
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00785-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity

Ali A. Abdul Sater, David M. Ojcius, and Matthew P. Meyer*

School of Natural Sciences, University of California, Merced, California 95344

* To whom correspondence should be addressed. Email: mmeyer{at}ucmerced.edu.


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Abstract

Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides against sexually-transmitted pathogens. However, HEC inhibits infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.






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