AAC Accepts, published online ahead of print on 23 October 2006
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00793-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

In Vitro Inhibition of Toxoplasma gondii by Four New Derivatives of Artemisinin

Lorraine Jones-Brando*, John D'Angelo, Gary H. Posner, and Robert Yolken

Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Chemistry and The Malaria Research Institute, Johns Hopkins University, Baltimore, MD

* To whom correspondence should be addressed. Email: lbrando{at}jhmi.edu,


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Abstract

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, non-acetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.




This article has been cited by other articles:

  • D'Angelo, J. G., Bordon, C., Posner, G. H., Yolken, R., Jones-Brando, L. (2009). Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle. J Antimicrob Chemother 63: 146-150 [Abstract] [Full Text]  
  • Spicher, M., Roethlisberger, C., Lany, C., Stadelmann, B., Keiser, J., Ortega-Mora, L. M., Gottstein, B., Hemphill, A. (2008). In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives. Antimicrob. Agents Chemother. 52: 3447-3450 [Abstract] [Full Text]  
  • Nagamune, K., Moreno, S. N. J., Sibley, L. D. (2007). Artemisinin-Resistant Mutants of Toxoplasma gondii Have Altered Calcium Homeostasis. Antimicrob. Agents Chemother. 51: 3816-3823 [Abstract] [Full Text]  
  • Nagamune, K., Beatty, W. L., Sibley, L. D. (2007). Artemisinin Induces Calcium-Dependent Protein Secretion in the Protozoan Parasite Toxoplasma gondii. Eukaryot Cell 6: 2147-2156 [Abstract] [Full Text]  
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