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AAC Accepts, published online ahead of print on 23 October 2006
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AAC.00793-06v1
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Antimicrob. Agents Chemother. doi:10.1128/AAC.00793-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

In Vitro Inhibition of Toxoplasma gondii by Four New Derivatives of Artemisinin

Lorraine Jones-Brando*, John D'Angelo, Gary H. Posner, and Robert Yolken

Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Chemistry and The Malaria Research Institute, Johns Hopkins University, Baltimore, MD

* To whom correspondence should be addressed. Email: lbrando{at}jhmi.edu,


  Abstract

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, non-acetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.


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