AAC Accepts, published online ahead of print on 13 October 2008

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Antimicrob. Agents Chemother. doi:10.1128/AAC.00810-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Lysine-Enriched Cecropin-Mellitin Antimicrobial Peptides with Enhanced Selectivity

Hiromi Sato and Jimmy B. Feix^*

Department of Microbiology and Molecular Genetics, Center for Biopreparedness and Infectious Disease, and Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226

^* To whom correspondence should be addressed. Email: jfeix{at}mcw.edu.

Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA_1-7 M_2-9 (designated CM15), designed with optimized amphipathicity retained antimicrobial activity similar to wild type CM15 and had substantially reduced hemolytic activity and cytotoxicity towards cultured macrophages, resulting in enhanced selectivity. These lysine-enriched analogs provide templates for improved CM15 peptide or peptidomimetic antibiotics.

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