AAC Accepts, published online ahead of print on 23 October 2006
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Papon, N.
Right arrow Articles by Chapeland-Leclerc, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Papon, N.
Right arrow Articles by Chapeland-Leclerc, F.

 Previous Article  |  Next Article 

Antimicrob. Agents Chemother. doi:10.1128/AAC.00824-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Molecular mechanism of flucytosine resistance in Candida lusitaniae: Contribution of the FCY2, FCY1 and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance

Nicolas Papon, Thierry Noël, Martine Florent, Stéphanie Gibot-Leclerc, Dorothée Jean, Christiane Chastin, Jean Villard, and Florence Chapeland-Leclerc*

Laboratoire des Sciences Végétales, EA209, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris 5, 4 avenue de l'Observatoire, 75006 Paris, France ; Laboratoire de Mycologie Moléculaire, UMR 5162 CNRS-Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France

* To whom correspondence should be addressed. Email: florence.leclerc{at}univ-paris5.fr.


arrow
Abstract

Inactivation of FCY2 (cytosine permease), FCY1 (cytosine deaminase) and FUR1 (uracil phosphoribosyl-transferase) genes in C. lusitaniae produced two patterns of resistance to 5-flucytosine. Mutant fur1 demonstrated resistance to 5-fluorouracil whereas mutants fcy1 and fcy2 demonstrated fluconazole resistance in the presence of subinhibitory 5-flucytosine concentrations.




This article has been cited by other articles:

  • McManus, B. A., Moran, G. P., Higgins, J. A., Sullivan, D. J., Coleman, D. C. (2009). A Ser29Leu Substitution in the Cytosine Deaminase Fca1p Is Responsible for Clade-Specific Flucytosine Resistance in Candida dubliniensis. Antimicrob. Agents Chemother. 53: 4678-4685 [Abstract] [Full Text]  
  • Florent, M., Noel, T., Ruprich-Robert, G., Da Silva, B., Fitton-Ouhabi, V., Chastin, C., Papon, N., Chapeland-Leclerc, F. (2009). Nonsense and Missense Mutations in FCY2 and FCY1 Genes Are Responsible for Flucytosine Resistance and Flucytosine-Fluconazole Cross-Resistance in Clinical Isolates of Candida lusitaniae. Antimicrob. Agents Chemother. 53: 2982-2990 [Abstract] [Full Text]  
  • Boisnard, S., Ruprich-Robert, G., Florent, M., Da Silva, B., Chapeland-Leclerc, F., Papon, N. (2008). Insight into the Role of HOG Pathway Components Ssk2p, Pbs2p, and Hog1p in the Opportunistic Yeast Candida lusitaniae. Eukaryot Cell 7: 2179-2183 [Abstract] [Full Text]  
  • Ruprich-Robert, G., Chapeland-Leclerc, F., Boisnard, S., Florent, M., Bories, G., Papon, N. (2008). Contributions of the Response Regulators Ssk1p and Skn7p in the Pseudohyphal Development, Stress Adaptation, and Drug Sensitivity of the Opportunistic Yeast Candida lusitaniae. Eukaryot Cell 7: 1071-1074 [Abstract] [Full Text]  
  • Chapeland-Leclerc, F., Paccallet, P., Ruprich-Robert, G., Reboutier, D., Chastin, C., Papon, N. (2007). Differential Involvement of Histidine Kinase Receptors in Pseudohyphal Development, Stress Adaptation, and Drug Sensitivity of the Opportunistic Yeast Candida lusitaniae. Eukaryot Cell 6: 1782-1794 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»