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Antimicrob. Agents Chemother. doi:10.1128/AAC.01004-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

HIV-1 and HIV-2 Exhibit Comparable Sensitivity to AZT and Other Nucleoside Analog Inhibitors In Vitro

Departments of Pathology and Medicine, University of Washington, Seattle WA

^* To whom correspondence should be addressed. Email: smithra{at}u.washington.edu.

	Abstract

Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) exhibit similar sensitivities to 3'-azido-3'-deoxythymidine (zidovudine [AZT]) as well as other nucleoside analog inhibitors of reverse transcriptase (RT). These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.