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Antimicrob. Agents Chemother. doi:10.1128/AAC.01028-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Phage therapy of Pseudomonas aeruginosa infection in the burn mouse model

^* To whom correspondence should be addressed. Email: joe.fralick{at}ttmc.ttuhsc.edu.

	Abstract

Mice, compromised by a burn wound injury and subjected to a fatal infection of Pseudomonas aeruginosa, were administered a single dose of a Pseudomonas aeruginosa (Pa) phage cocktail, consisting of three different Pa phages, via three different routes: intramuscularly (IM), subcutaneously (SC), or intraperitoneally (IP). The results of these studies indicated that a single dose of the Pa phage cocktail could significantly decrease the mortality of thermally injured, P. aeruginosa infected mice (from 6% survival without treatment to 22-87% survival with treatment) and that the route of administration was particularly important to the efficacy of the treatment, with the IP route providing the most significant (87%) protection. Pharmacokinetics of phage delivery to the blood, spleen and liver suggested that phage administered by the IP route were delivered at a higher dose, earlier and for a more sustained period of time than were those administered via IM or SC which may explain the differences in efficacy via these three different routes of administration.