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Antimicrob. Agents Chemother. doi:10.1128/AAC.01070-06
Copyright (c) 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Emergence and Dissemination of CTX-M-1-like-producing Enterobacteriaceae in Spain is Caused by IncFII (CTX-M-15) and Broad Host Range (CTX-M-1,-3,-32) Plasmids

Hospital Universitario Ramón y Cajal, IMSALUD, Madrid, Spain; Unidad de Resistencia a Antibióticos y Virulencia Bacteriana asociada al Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; Faculdade Farmacia, Universidade do Porto, Portugal

^* To whom correspondence should be addressed. Email: mcoque.hrc{at}salud.madrid.org.

	Abstract

Spread of CTX-M-1-like enzymes in Spain is associated with particular plasmids of broad host range IncN (bla_CTX-M-32, bla_CTX-M-1), IncL/M (bla_CTX-M-1) and IncA/C₂ (bla_CTX-M-3) or narrow host range IncFII (bla_CTX-M-15). Identical genetic surroundings of bla_CTX-M-32 and bla_CTX-M-1 and location on related 40kb IncN plasmids indicate in vivo evolution of this element.

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