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Antimicrob. Agents Chemother. doi:10.1128/AAC.01370-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Efficacy of SPK-843, a Novel Polyene Antifungal in a Murine Model of Systemic Cryptococcosis

Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Bioactive Molecules, National Institute of Infectious Disease, Japan; Kaken Pharmaceutical Co., Ltd., Kyoto, Japan

^* To whom correspondence should be addressed. Email: kakeya{at}nagasaki-u.ac.jp.

	Abstract

SPK-843, a new polyene antifungal, possessed efficacy against a murine systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 revealed better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (p < 0.001) without histopathological renal changes.