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Antimicrob. Agents Chemother. doi:10.1128/AAC.01382-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

In-vitro activity of miltefosine and two novel antifungal bis-cationic salts against a panel of 77 dermatophytes

Research Laboratory for Infectious Skin Diseases, Department of Dermatology, Wuhan First Hospital, Wuhan, People's Republic of China, Centre for Infectious Diseases and Microbiology, the Centre for Clinical Research Excellence in Infections, Bioethics and Haematological Malignancies and The University of Sydney at Westmead, Centre for Infectious Diseases and Microbiology Laboratory Services, School of Chemistry, The University of Sydney

^* To whom correspondence should be addressed. Email: sharonc{at}icpmr.wsahs.nsw.gov.au.

	Abstract

The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM)), itraconazole (ITC), terbinafine (TRB) and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, AM were 0.039, 0.059, 1.718, 0.671, 6.006 and 4.771 µg/ml, respectively. MI was more active than ITC (P < 0.001).