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Antimicrob. Agents Chemother. doi:10.1128/AAC.01425-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Assessment of Serum (13)--D-Glucan as a Measure of Disease Burden in a Murine Model of Invasive Pulmonary Aspergillosis

The University of Texas at Austin College of Pharmacy, Austin, TX, The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, San Antonio, TX

^* To whom correspondence should be addressed. Email: wiederholdn{at}uthscsa.edu.

	Abstract

Serum (13)--D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (13)--D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.