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Antimicrob. Agents Chemother. doi:10.1128/AAC.01446-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Safety and activity of the immune modulator HE2000 on the incidence of tuberculosis and other opportunistic infections in AIDS patients

Hollis-Eden Pharmaceuticals, Inc., San Diego, CA USA; Karl Bremmer Hospital, Cape Town, Republic of South Africa

^* To whom correspondence should be addressed. Email: dstickney{at}holliseden.com.

	Abstract

Twenty-five AIDS patients were treated with HE2000, a synthetic adrenal hormone. The drug was well tolerated, safe, and reduced both the incidence of tuberculosis co-infection by 42.2% (p<0.05) and the cumulative incidence of opportunistic infections (p<0.05). These results warrant further clinical investigation.

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