AAC Accepts, published online ahead of print on 26 February 2007
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Antimicrob. Agents Chemother. doi:10.1128/AAC.01453-06
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Clonal spread of mef positive macrolide-resistant Streptococcus pneumoniae in invasive disease in adults in Germany

Mark van der Linden, Adnan Al-Lahham, Stefan Haupts, and Ralf René Reinert*

Institute of Medical Microbiology, National Reference Center for Streptococci, University Hospital (RWTH), Aachen, Germany

* To whom correspondence should be addressed. Email: Reinert{at}rwth-aachen.de.


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Abstract

3845 isolates from invasive pneumococcal disease in German adults were investigated between 1992 and 2004. 430 isolates were erythromycin-A non-susceptible (11.2%). Macrolide-resistance genotypes and MLSTs were determined. 35.6% were erm(B)-positive and 63.5% mef-positive. Resistance rose significantly from 2.2% to 17.0% (p<0.001). A serotype 14, ST9 clone was the most widespread.




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