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Antimicrob. Agents Chemother. doi:10.1128/AAC.01485-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Induction of L1 and L2 -Lactamase Production in Stenotrophomonas maltophilia is Dependent on an AmpR-Type Regulator

Bristol Centre for Antimicrobial Research and Evaluation, Department of Cellular & Molecular Medicine, University of Bristol, United Kingdom

^* To whom correspondence should be addressed. Email: matthewb.avison{at}bris.ac.uk.

	Abstract

A divergently oriented ampR has been located upstream of bla_L2 in Stenotrophomonas maltophilia. AmpR is necessary for L1 and L2 -lactamase induction in response to -lactam challenge and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction.