AAC Accepts, published online ahead of print on 9 June 2008
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Antimicrob. Agents Chemother. doi:10.1128/AAC.01570-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism

Fernanda S. Spies, Pedro E. Almeida da Silva, Marta O. Ribeiro, Maria Lucia Rossetti, and Arnaldo Zaha*

Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil; Fundação Estadual de Produção e Pesquisa em Saúde do Estado do Rio Grande do Sul (FEPPS), Porto Alegre, Brazil; Programa de Pós-Graduação em Ciências da Saúde - Universidade Federal do Rio Grande (FURG), Campus da Saúde, Rio Grande, Brazil; Programa de Pós-graduação em Ciências em Genética e Toxicologia Aplicada- Universidade Luterana do Brasil (ULBRA), Canoas, Brazil; Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

* To whom correspondence should be addressed. Email: zaha{at}cbiot.ufrgs.br.


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Abstract

MIC for streptomycin in presence of efflux pump inhibitors, and the sequencing of rpsL, rrs and gidB genes provided evidence for the possible participation of efflux pumps in low level STR-resistance of some isolates without mutations. Mutation in gidB gene and efflux pump could act synergistically to confer low STR-resistance.




This article has been cited by other articles:

  • Louw, G. E., Warren, R. M., Gey van Pittius, N. C., McEvoy, C. R. E., Van Helden, P. D., Victor, T. C. (2009). A Balancing Act: Efflux/Influx in Mycobacterial Drug Resistance. Antimicrob. Agents Chemother. 53: 3181-3189 [Full Text]  


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