AAC Accepts, published online ahead of print on 17 February 2009

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Antimicrob. Agents Chemother. doi:10.1128/AAC.01593-08
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

HIV-1 Isolates with the RT Mutation Q145M Retain Nucleoside and Non-Nucleoside RT Inhibitor Susceptibility

Vici Varghese, Yumi Mitsuya, Rajin Shahriar, Michael H. Bachmann, W. Jeffrey Fessel, Ron M. Kagan, and Robert W. Shafer^*

Dept. of Medicine, Stanford University School of Medicine, Stanford, CA; Dept. of Pediatrics, Stanford University School of Medicine, Stanford, CA; Kaiser Permanente Medical Care Program – Northern California, San Francisco, CA; Dept. of Infectious Diseases, Quest Diagnostics, San Juan Capistrano, CA

^* To whom correspondence should be addressed. Email: rshafer{at}stanford.edu.

Q145M, a mutation in a conserved HIV-1 reverse transcriptase (RT) region, was reported to decrease susceptibility to multiple RT inhibitors. We report that Q145M and other Q145 mutations do not emerge with RT inhibitors nor decrease RT inhibitor susceptibility. Q145M should therefore not be considered an RT inhibitor resistance mutation.