AAC Accepts, published online ahead of print on 21 April 2008

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Antimicrob. Agents Chemother. doi:10.1128/AAC.01618-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Impact of Mycophenolic Acid on the Functionality of Human Polymorphonuclear Neutrophils and Dendritic Cells during Interaction with Aspergillus fumigatus

Markus Mezger, Iwona Wozniok, Christian Blockhaus, Oliver Kurzai, Holger Hebart, Hermann Einsele, and Juergen Loeffler^*

Universität Würzburg, Medizinische Klinik & Poliklinik II, Institut für Hygiene und Mikrobiologie, 97070 Würzburg; Staufer-Klinik Schwäbisch Gmünd, Innere Medizin, 73557 Mutlangen

^* To whom correspondence should be addressed. Email: loeffler_j{at}klinik.uni-wuerzburg.de.

Mycophenolic acid (MPA) is clinically used to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils but without a corresponding increase in fungal killing. Further, MPA inhibited pro-inflammatory cytokine response and maturation of dendritic cells.