AAC Accepts, published online ahead of print on 30 March 2009

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Antimicrob. Agents Chemother. doi:10.1128/AAC.01716-08
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients with invasive infections, ranging from newborns to the elderly

Somay Yamagata Murayama, Chizuko Seki, Hiroshi Sakata, Katsuhiko Sunaoshi, Eiichi Nakayama, Satoshi Iwata, Keisuke Sunakawa, Kimiko Ubukata^*, and the Invasive Streptococcal Disease Working Group

Laboratory of Molecular Epidemiology for Infectious Agents, Graduate School of Infection Control Sciences & Kitasato Institute for Life Sciences, Kitasato University 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan; Department of Pediatrics, Asahikawa-Kosei General Hospital, 1-24 Asahikawa City, Hokkaido 078-8211, Japan; Department of Pediatrics, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan; Laboratory of Infectious Diseases, Kitasato Institute for Life Sciences, Kitasato University 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

^* To whom correspondence should be addressed. Email: ubukatak{at}lisci.kitasato-u.ac.jp.

Streptococcus agalactiae (n = 189) isolates from patients with invasive infection were analyzed for capsular type by PCR, for antimicrobial susceptibility, and for presence of resistance genes. In contrast to predominance of capsular type III in children, types Ib and V were most common among adults. All 45 levofloxacin-resistant strains had 2 amino acid substitutions: Ser₈₁Leu in the gyrA and Ser₇₉Phe in the parC gene, showing similar pulsed-field gel electrophoresis patterns.