AAC -- Table of Contents (December 1 1994, 38 [12])

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Contents: December 1994, Volume 38, Issue 12

Research Article

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Research Article:

How the pharmaceutical industry brings an antibiotic drug to market in the United States.
S A Billstein
Antimicrob. Agents Chemother. December 1994 38: 2679-2682;
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Parenteral sparfloxacin compared with ceftriaxone in treatment of experimental endocarditis due to penicillin-susceptible and -resistant streptococci.
J M Entenza, M Blatter, M P Glauser, and P Moreillon
Antimicrob. Agents Chemother. December 1994 38: 2683-2688;
[Abstract] [PDF] [Reprints and Permissions]

Evidence of alkaline phosphatase interference in a zidovudine radioimmunoassay.
A M O'Donnell, D J Letting, M F DeRemer, and G D Morse
Antimicrob. Agents Chemother. December 1994 38: 2689-2694;
[Abstract] [PDF] [Reprints and Permissions]

Pharmacokinetics, toxicity, and efficacy of liposomal capreomycin in disseminated Mycobacterium avium beige mouse model.
P Le Conte, F Le Gallou, G Potel, L Struillou, D Baron, and H B Drugeon
Antimicrob. Agents Chemother. December 1994 38: 2695-2701;
[Abstract] [PDF] [Reprints and Permissions]

Pharmacodynamics of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with rifampin, against methicillin-susceptible and -resistant Staphylococcus aureus in an in vitro infection model.
S L Kang, M J Rybak, B J McGrath, G W Kaatz, and S M Seo
Antimicrob. Agents Chemother. December 1994 38: 2702-2709;
[Abstract] [PDF] [Reprints and Permissions]

The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication.
J Neyts, G Andrei, R Snoeck, G Jähne, I Winkler, M Helsberg, J Balzarini, and E De Clercq
Antimicrob. Agents Chemother. December 1994 38: 2710-2716;
[Abstract] [PDF] [Reprints and Permissions]

Clarithromycin, dapsone, and a combination of both used to treat or prevent disseminated Mycobacterium avium infection in beige mice.
L E Bermudez, C B Inderlied, P Kolonoski, M Petrofsky, and L S Young
Antimicrob. Agents Chemother. December 1994 38: 2717-2721;
[Abstract] [PDF] [Reprints and Permissions]

Pharmacokinetics, oral bioavailability, and metabolism in mice and cynomolgus monkeys of (2'R,5'S-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, an agent active against human immunodeficiency virus and human hepatitis B virus.
L W Frick, C U Lambe, L St John, L C Taylor, and D J Nelson
Antimicrob. Agents Chemother. December 1994 38: 2722-2729;
[Abstract] [PDF] [Reprints and Permissions]

Pharmacokinetic and pharmacodynamic activities of ciprofloxacin against strains of Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa for which MICs are similar.
J M Hyatt, D E Nix, and J J Schentag
Antimicrob. Agents Chemother. December 1994 38: 2730-2737;
[Abstract] [PDF] [Reprints and Permissions]

Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium.
N Mor, J Vanderkolk, N Mezo, and L Heifets
Antimicrob. Agents Chemother. December 1994 38: 2738-2742;
[Abstract] [PDF] [Reprints and Permissions]

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis.
J L Martin, C E Brown, N Matthews-Davis, and J E Reardon
Antimicrob. Agents Chemother. December 1994 38: 2743-2749;
[Abstract] [PDF] [Reprints and Permissions]

Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.
M B Kurtz, C Douglas, J Marrinan, K Nollstadt, J Onishi, S Dreikorn, J Milligan, S Mandala, J Thompson, and J M Balkovec
Antimicrob. Agents Chemother. December 1994 38: 2750-2757;
[Abstract] [PDF] [Reprints and Permissions]

Pharmacokinetics of the triazole antifungal agent genaconazole in healthy men after oral and intravenous administration.
P Mojaverian, E Radwanski, M B Affrime, M N Cayen, and C C Lin
Antimicrob. Agents Chemother. December 1994 38: 2758-2762;
[Abstract] [PDF] [Reprints and Permissions]

Application of a radioimmunoassay for determination of levels of zalcitabine (ddC) in human plasma, urine, and cerebrospinal fluid.
D M Burger, H Rosing, C H ten Napel, T Duyts, P L Meenhorst, J W Mulder, C H Koks, A Bult, and J H Beijnen
Antimicrob. Agents Chemother. December 1994 38: 2763-2767;
[Abstract] [PDF] [Reprints and Permissions]

Quantification, qualification, and microbial killing efficiencies of antimicrobial chlorine-based substances produced by iontophoresis.
C P Davis, M E Shirtliff, N M Trieff, S L Hoskins, and M M Warren
Antimicrob. Agents Chemother. December 1994 38: 2768-2774;
[Abstract] [PDF] [Reprints and Permissions]

Nitric oxide donor-mediated killing of bioluminescent Escherichia coli.
M Virta, M Karp, and P Vuorinen
Antimicrob. Agents Chemother. December 1994 38: 2775-2779;
[Abstract] [PDF] [Reprints and Permissions]

Penetration of piperacillin-tazobactam into bronchial secretions after multiple doses to intensive care patients.
F Jehl, C Muller-Serieys, V de Larminat, H Monteil, and E Bergogne-Berezin
Antimicrob. Agents Chemother. December 1994 38: 2780-2784;
[Abstract] [PDF] [Reprints and Permissions]

Intranasal monoclonal immunoglobulin A against respiratory syncytial virus protects against upper and lower respiratory tract infections in mice.
R Weltzin, S A Hsu, E S Mittler, K Georgakopoulos, and T P Monath
Antimicrob. Agents Chemother. December 1994 38: 2785-2791;
[Abstract] [PDF] [Reprints and Permissions]

Phosphatidylazidothymidine and phosphatidyl-ddC: assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunodeficiency virus-infected cells and in Rauscher leukemia virus-infected mice.
K Y Hostetler, D D Richman, C N Sridhar, P L Felgner, J Felgner, J Ricci, M F Gardner, D W Selleseth, and M N Ellis
Antimicrob. Agents Chemother. December 1994 38: 2792-2797;
[Abstract] [PDF] [Reprints and Permissions]

Possible implications of doxycycline-rifampin interaction for treatment of brucellosis.
J D Colmenero, L C Fernández-Gallardo, J A Agúndez, J Sedeño, J Benítez, and E Valverde
Antimicrob. Agents Chemother. December 1994 38: 2798-2802;
[Abstract] [PDF] [Reprints and Permissions]

Mechanism of electrical enhancement of efficacy of antibiotics in killing biofilm bacteria.
J W Costerton, B Ellis, K Lam, F Johnson, and A E Khoury
Antimicrob. Agents Chemother. December 1994 38: 2803-2809;
[Abstract] [PDF] [Reprints and Permissions]

Effect of magnesium complexation by fluoroquinolones on their antibacterial properties.
S Lecomte, M H Baron, M T Chenon, C Coupry, and N J Moreau
Antimicrob. Agents Chemother. December 1994 38: 2810-2816;
[Abstract] [PDF] [Reprints and Permissions]

Single-dose pharmacokinetics of piperacillin and tazobactam in infants and children.
M D Reed, J Goldfarb, T S Yamashita, E Lemon, and J L Blumer
Antimicrob. Agents Chemother. December 1994 38: 2817-2826;
[Abstract] [PDF] [Reprints and Permissions]

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds.
J Tomassini, H Selnick, M E Davies, M E Armstrong, J Baldwin, M Bourgeois, J Hastings, D Hazuda, J Lewis, and W McClements
Antimicrob. Agents Chemother. December 1994 38: 2827-2837;
[Abstract] [PDF] [Reprints and Permissions]

Extended-spectrum beta-lactamases in clinical isolates of Enterobacter gergoviae and Escherichia coli in China.
Y Cheng and M Chen
Antimicrob. Agents Chemother. December 1994 38: 2838-2842;
[Abstract] [PDF] [Reprints and Permissions]

Effects of antifungal agent combinations administered simultaneously and sequentially against Aspergillus fumigatus.
S Maesaki, S Kohno, M Kaku, H Koga, and K Hara
Antimicrob. Agents Chemother. December 1994 38: 2843-2845;
[Abstract] [PDF] [Reprints and Permissions]

Simulation of amoxicillin pharmacokinetics in humans for the prevention of streptococcal endocarditis in rats.
U Fluckiger, P Moreillon, J Blaser, M Bickle, M P Glauser, and P Francioli
Antimicrob. Agents Chemother. December 1994 38: 2846-2849;
[Abstract] [PDF] [Reprints and Permissions]

Characterization of the PNT1 pentamidine resistance gene of Saccharomyces cerevisiae.
G Ludewig and C Staben
Antimicrob. Agents Chemother. December 1994 38: 2850-2856;
[Abstract] [PDF] [Reprints and Permissions]

New in vitro assay based on glucose consumption for determining intraconazole and amphotericin B activities against Aspergillus fumigatus.
J C Garrigues, G Cadet de Fontenay, M D Linas, M Lagente, and J P Seguela
Antimicrob. Agents Chemother. December 1994 38: 2857-2862;
[Abstract] [PDF] [Reprints and Permissions]

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs.
R Pauwels, K Andries, Z Debyser, M J Kukla, D Schols, H J Breslin, R Woestenborghs, J Desmyter, M A Janssen, and E De Clercq
Antimicrob. Agents Chemother. December 1994 38: 2863-2870;
[Abstract] [PDF] [Reprints and Permissions]

Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum.
P K Rathod, M Khosla, S Gassis, R D Young, and C Lutz
Antimicrob. Agents Chemother. December 1994 38: 2871-2876;
[Abstract] [PDF] [Reprints and Permissions]

In vitro and in vivo antimycobacterial activities of a new quinolone, DU-6859a.
H Saito, H Tomioka, K Sato, and S Dekio
Antimicrob. Agents Chemother. December 1994 38: 2877-2882;
[Abstract] [PDF] [Reprints and Permissions]

In vitro and ex vivo effects of cyclosporin A on phagocytic host defenses against Aspergillus fumigatus.
E Roilides, T Robinson, T Sein, P A Pizzo, and T J Walsh
Antimicrob. Agents Chemother. December 1994 38: 2883-2888;
[Abstract] [PDF] [Reprints and Permissions]

Inhibition of human cytomegalovirus in culture by alkenyl guanine analogs of the thiazolo[4,5-d]pyrimidine ring system.
A F Lewis, J C Drach, S M Fennewald, J H Huffman, R G Ptak, J P Sommadossi, G R Revankar, and R F Rando
Antimicrob. Agents Chemother. December 1994 38: 2889-2895;
[Abstract] [PDF] [Reprints and Permissions]

In vitro activity of SCE-2787, a new cephalosporin with potent activity against Pseudomonas aeruginosa and members of the family Enterobacteriaceae.
O Klein, N X Chin, H B Huang, and H C Neu
Antimicrob. Agents Chemother. December 1994 38: 2896-2901;
[Abstract] [PDF] [Reprints and Permissions]

In vitro susceptibilities of 185 penicillin-susceptible and -resistant pneumococci to WY-49605 (SUN/SY 5555), a new oral penem, compared with those to penicillin G, amoxicillin, amoxicillin-clavulanate, cefixime, cefaclor, cefpodoxime, cefuroxime, and cefdinir.
S K Spangler, M R Jacobs, and P C Appelbaum
Antimicrob. Agents Chemother. December 1994 38: 2902-2904;
[Abstract] [PDF] [Reprints and Permissions]

Susceptibilities of 200 penicillin-susceptible and -resistant pneumococci to piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate, ampicillin, ampicillin-sulbactam, ceftazidime, and ceftriaxone.
G A Pankuch, M R Jacobs, and P C Appelbaum
Antimicrob. Agents Chemother. December 1994 38: 2905-2907;
[Abstract] [PDF] [Reprints and Permissions]

In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae.
A M Dhople, M A Ibanez, and A A Dhople
Antimicrob. Agents Chemother. December 1994 38: 2908-2909;
[Abstract] [PDF] [Reprints and Permissions]

Influence of host cell type and V3 loop of the surface glycoprotein on susceptibility of human immunodeficiency virus type 1 to polyanion compounds.
P R Meylan, R S Kornbluth, I Zbinden, and D D Richman
Antimicrob. Agents Chemother. December 1994 38: 2910-2916;
[Abstract] [PDF] [Reprints and Permissions]

Susceptibilities to 10 antimicrobial agents of 1,220 Campylobacter strains isolated from 1987 to 1993 from feces of pediatric patients.
J Reina, M J Ros, and A Serra
Antimicrob. Agents Chemother. December 1994 38: 2917-2920;
[Abstract] [PDF] [Reprints and Permissions]

Inhibition of hepatitis B virus in tissue culture by alpha interferon.
M G Davis and R W Jansen
Antimicrob. Agents Chemother. December 1994 38: 2921-2924;
[Abstract] [PDF] [Reprints and Permissions]

Detection of aac(6')-I genes in amikacin-resistant Acinetobacter spp. by PCR.
M C Ploy, H Giamarellou, P Bourlioux, P Courvalin, and T Lambert
Antimicrob. Agents Chemother. December 1994 38: 2925-2928;
[Abstract] [PDF] [Reprints and Permissions]

Human immunodeficiency virus type 1 virions composed of unprocessed Gag and Gag-Pol precursors are capable of reverse transcribing viral genomic RNA.
A H Kaplan, P Krogstad, D J Kempf, D W Norbeck, and R Swanstrom
Antimicrob. Agents Chemother. December 1994 38: 2929-2933;
[Abstract] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.