Contents: October 1998, Volume 42, Issue 10        Experimental Therapeutics        Mechanisms of Resistance        Antiviral Agents        Susceptibility        Mechanisms of Action        Pharmacology        Analytical Procedures        Letters        Errata        Author's Correction Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Experimental Therapeutics:

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Granulocyte Colony-Stimulating Factor and Azole Antifungal Therapy in Murine Aspergillosis: Role of Immune Suppression John R. Graybill, Rosie Bocanegra, Laura K. Najvar, David Loebenberg, and Mike F. Luther Antimicrob. Agents Chemother. October 1998 42: 2467-2473; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mucoadhesive Microspheres Containing Amoxicillin for Clearance of Helicobacter pylori Naoki Nagahara, Yohko Akiyama, Masafumi Nakao, Mayumi Tada, Megumi Kitano, and Yasuyuki Ogawa Antimicrob. Agents Chemother. October 1998 42: 2492-2494; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interaction of Streptococcus pneumoniae and Moraxella catarrhalis: Investigation of the Indirect Pathogenic Role of -Lactamase-Producing Moraxellae by Use of a Continuous-Culture Biofilm System R. K. Budhani and J. K. Struthers Antimicrob. Agents Chemother. October 1998 42: 2521-2526; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduction by Cefodizime of the Pulmonary Inflammatory Response Induced by Heat-Killed Streptococcus pneumoniae in Mice Yves Bergeron, Nathalie Ouellet, Anne-Marie Deslauriers, Marie Simard, Martin Olivier, and Michel G. Bergeron Antimicrob. Agents Chemother. October 1998 42: 2527-2533; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacies of KY62 against Leishmania amazonensis and Leishmania donovani in Experimental Murine Cutaneous Leishmaniasis and Visceral Leishmaniasis Hail M. Al-Abdely, John R. Graybill, Rosie Bocanegra, Laura Najvar, Eleanor Montalbo, Steven L. Regen, and Peter C. Melby Antimicrob. Agents Chemother. October 1998 42: 2542-2548; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interleukin-12 Enhances In Vivo Parasiticidal Effect of Benznidazole during Acute Experimental Infection with a Naturally Drug-Resistant Strain of Trypanosoma cruzi Vladimir Michailowsky, Silvane M. F. Murta, Leonardo Carvalho-Oliveira, Maria E. S. Pereira, Ludmila R. P. Ferreira, Zigman Brener, Alvaro J. Romanha, and Ricardo T. Gazzinelli Antimicrob. Agents Chemother. October 1998 42: 2549-2556; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Efficacy of the Triazole TAK-187 against Cryptococcus neoformans Wiley A. Schell, Gisele Madeira Duboc De Almeida, Richard K. Dodge, Kenji Okonogi, and John R. Perfect Antimicrob. Agents Chemother. October 1998 42: 2630-2632; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of Gatifloxacin in Cerebrospinal Fluid in Experimental Cephalosporin-Resistant Pneumococcal Meningitis Irja Lutsar, Ian R. Friedland, Loretta Wubbel, Cynthia C. McCoig, Hasan S. Jafri, Winston Ng, Faryal Ghaffar, and George H. McCracken, Jr. Antimicrob. Agents Chemother. October 1998 42: 2650-2655; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Efficacy of ABT-255 against Drug-Sensitive and -Resistant Mycobacterium tuberculosis Strains Andy Oleksijew, Jon Meulbroek, Patty Ewing, Ken Jarvis, Mike Mitten, Lenette Paige, Ann Tovcimak, Mike Nukkula, Daniel Chu, and Jeffrey D. Alder Antimicrob. Agents Chemother. October 1998 42: 2674-2677; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of Microsphere Technology for Targeted Delivery of Rifampin to Mycobacterium tuberculosis-Infected Macrophages Esther L. W. Barrow, Gary A. Winchester, Jay K. Staas, Debra C. Quenelle, and William W. Barrow Antimicrob. Agents Chemother. October 1998 42: 2682-2689; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Treatment of Vancomycin-Resistant Enterococcus faecium with RP 59500 (Quinupristin-Dalfopristin) Administered by Intermittent or Continuous Infusion, Alone or in Combination with Doxycycline, in an In Vitro Pharmacodynamic Infection Model with Simulated Endocardial Vegetations Jeffrey R. Aeschlimann, Marcus J. Zervos, and Michael J. Rybak Antimicrob. Agents Chemother. October 1998 42: 2710-2717; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antitrypanosomal Activity of a New Triazine Derivative, SIPI 1029, In Vitro and in Model Infections Cyrus J. Bacchi, Marcus Vargas, Donna Rattendi, Burt Goldberg, and Weicheng Zhou Antimicrob. Agents Chemother. October 1998 42: 2718-2721; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Visceral Leishmaniasis in the BALB/c Mouse: A Comparison of the Efficacy of a Nonionic Surfactant Formulation of Sodium Stibogluconate with Those of Three Proprietary Formulations of Amphotericin B A. B. Mullen, A. J. Baillie, and K. C. Carter Antimicrob. Agents Chemother. October 1998 42: 2722-2725; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Sequencing of Gyrase and Topoisomerase IV Quinolone-Resistance-Determining Regions of Chlamydia trachomatis and Characterization of Quinolone-Resistant Mutants Obtained In Vitro Sophie Dessus-Babus, Cécile M. Bébéar, Alain Charron, Christiane Bébéar, and Bertille de Barbeyrac Antimicrob. Agents Chemother. October 1998 42: 2474-2481; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of In40 of Enterobacter aerogenes BM2688, a Class 1 Integron with Two New Gene Cassettes, cmlA2 and qacF Marie-Cécile Ploy, Patrice Courvalin, and Thierry Lambert Antimicrob. Agents Chemother. October 1998 42: 2557-2563; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Roles of Amino Acids 161 to 179 in the PSE-4  Loop in Substrate Specificity and in Resistance to Ceftazidime Christian Therrien, Francois Sanschagrin, Timothy Palzkill, and Roger C. Levesque Antimicrob. Agents Chemother. October 1998 42: 2576-2583; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid, Transient Fluconazole Resistance in Candida albicans Is Associated with Increased mRNA Levels of CDR Kieren A. Marr, Christopher N. Lyons, Tiger Rustad, Raleigh A. Bowden, and Theodore C. White Antimicrob. Agents Chemother. October 1998 42: 2584-2589; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Mutations in the rpoB Gene That Confer Rifampin Resistance in Staphylococcus aureus Hélène Aubry-Damon, Claude-James Soussy, and Patrice Courvalin Antimicrob. Agents Chemother. October 1998 42: 2590-2594; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of a Glycosyl Transferase Inactivating Macrolides, Encoded by gimA from Streptomyces ambofaciens Anne Gourmelen, Marie-Hélène Blondelet-Rouault, and Jean-Luc Pernodet Antimicrob. Agents Chemother. October 1998 42: 2612-2619; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Fluconazole Resistance in Candida krusei Alison S. Orozco, Lindsey M. Higginbotham, Christopher A. Hitchcock, Tanya Parkinson, Derek Falconer, Ashraf S. Ibrahim, Mahmoud A. Ghannoum, and Scott G. Filler Antimicrob. Agents Chemother. October 1998 42: 2645-2649; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

gyrA Mutations Associated with Fluoroquinolone Resistance in Eight Species of Enterobacteriaceae Linda M. Weigel, Christine D. Steward, and Fred C. Tenover Antimicrob. Agents Chemother. October 1998 42: 2661-2667; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Explaining the Bias in the 23S rRNA Gene Mutations Associated with Clarithromycin Resistance in Clinical Isolates of Helicobacter pylori Y. J. Debets-Ossenkopp, A. B. Brinkman, E. J. Kuipers, C. M. J. E. Vandenbroucke-Grauls, and J. G. Kusters Antimicrob. Agents Chemother. October 1998 42: 2749-2751; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of IS18, an Element Capable of Activating the Silent aac(6')-Ij Gene of Acinetobacter sp. 13 Strain BM2716 by Transposition Eric Rudant, Patrice Courvalin, and Thierry Lambert Antimicrob. Agents Chemother. October 1998 42: 2759-2761; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Description of Two New Isolates of Streptococcus pneumoniae in Spain That Are Highly Resistant to Cefotaxime Joaquín Ruiz, Marco Sempere, Encarnación Simarro, and Asunción Fenoll Antimicrob. Agents Chemother. October 1998 42: 2768-2769; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Restoration of Immune Response by a Cationic Amphiphilic Drug (AY 9944) In Vitro: A New Approach To Chemotherapy against Human Immunodeficiency Virus Type 1 Ammar Achour, Jean-Charles Landureau, Rosangela Salerno-Concalves, Jean-Claude Mazière, and Daniel Zagury Antimicrob. Agents Chemother. October 1998 42: 2482-2491; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genotypic and Phenotypic Characterization of Human Immunodeficiency Virus Type 1 Variants Isolated from Patients Treated with the Protease Inhibitor Nelfinavir A. K. Patick, M. Duran, Y. Cao, D. Shugarts, M. R. Keller, E. Mazabel, M. Knowles, S. Chapman, D. R. Kuritzkes, and M. Markowitz Antimicrob. Agents Chemother. October 1998 42: 2637-2644; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents Maurizio Del Poeta, Wiley A. Schell, Christine C. Dykstra, Susan Jones, Richard R. Tidwell, Agnieszka Czarny, Miroslav Bajic, Marina Bajic, Arvind Kumar, David Boykin, and John R. Perfect Antimicrob. Agents Chemother. October 1998 42: 2495-2502; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antifungal Activities of a Series of Dication-Substituted Carbazoles, Furans, and Benzimidazoles Maurizio Del Poeta, Wiley A. Schell, Christine C. Dykstra, Susan K. Jones, Richard R. Tidwell, Arvind Kumar, David W. Boykin, and John R. Perfect Antimicrob. Agents Chemother. October 1998 42: 2503-2510; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Delivery and Antibacterial Activity of Gentamicin Encapsulated in pH-Sensitive Liposomes Peter Lutwyche, Carol Cordeiro, David J. Wiseman, Maryse St-Louis, Mitchell Uh, Michael J. Hope, Murray S. Webb, and B. Brett Finlay Antimicrob. Agents Chemother. October 1998 42: 2511-2520; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification and Characterization of Novel Antimicrobial Decapeptides Generated by Combinatorial Chemistry Sung Yu Hong, Jong Eun Oh, Mi yun Kwon, Myeong Jun Choi, Ji Hye Lee, Bok Luel Lee, Hong Mo Moon, and Keun Hyeung Lee Antimicrob. Agents Chemother. October 1998 42: 2534-2541; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Inhibitory and Bactericidal Activities and Postantibiotic Effects of LY333328 and Ampicillin Used Singly and in Combination against Vancomycin-Resistant Enterococcus faecium Aldona L. Baltch, Raymond P. Smith, William J. Ritz, and Lawrence H. Bopp Antimicrob. Agents Chemother. October 1998 42: 2564-2568; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Susceptibility Patterns of Streptococcus pneumoniae in China and Comparison of MICs by Agar Dilution and E-Test Methods Hui Wang, Robin Huebner, Minjun Chen, and Keith Klugman Antimicrob. Agents Chemother. October 1998 42: 2633-2636; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Haemophilus ducreyi Is Susceptible to Protegrin Kate Fortney, Patricia A. Totten, Robert I. Lehrer, and Stanley M. Spinola Antimicrob. Agents Chemother. October 1998 42: 2690-2693; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of the Echinocandin Antifungal Agent LY303,366 in Comparison with Itraconazole and Amphotericin B against Aspergillus spp. Karen L. Oakley, Caroline B. Moore, and David W. Denning Antimicrob. Agents Chemother. October 1998 42: 2726-2730; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Studies of Pharmacodynamic Properties of Vancomycin against Staphylococcus aureus and Staphylococcus epidermidis E. Löwdin, I. Odenholt, and O. Cars Antimicrob. Agents Chemother. October 1998 42: 2739-2744; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibility of Coxiella burnetii to Trovafloxacin in Comparison with Susceptibilities to Pefloxacin, Ciprofloxacin, Ofloxacin, Doxycycline, and Clarithromycin Achilleas Gikas, Ioanna Spyridaki, Anna Psaroulaki, Diamantis Kofterithis, and Yannis Tselentis Antimicrob. Agents Chemother. October 1998 42: 2747-2748; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of 15 Antimicrobial Agents against Clinical Isolates of South African Enterococci M. C. Struwig, P. L. Botha, and L. J. Chalkley Antimicrob. Agents Chemother. October 1998 42: 2752-2755; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Chlamydia pneumoniae Strains Recovered from Atherosclerotic Coronary Arteries Jens Gieffers, Werner Solbach, and Matthias Maass Antimicrob. Agents Chemother. October 1998 42: 2762-2764; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

PMX-622 (Polymyxin B-Dextran 70) Does Not Alter In Vitro Activities of 11 Antimicrobial Agents Peter C. Fuchs, Arthur L. Barry, and Steven D. Brown Antimicrob. Agents Chemother. October 1998 42: 2765-2767; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Accumulation of Amphotericin B in Human Macrophages Enhances Activity against Aspergillus fumigatus Conidia: Quantification of Conidial Kill at the Single-Cell Level Bernhard Jahn, Albert Rampp, Christian Dick, Andreas Jahn, Michael Palmer, and Sucharit Bhakdi Antimicrob. Agents Chemother. October 1998 42: 2569-2575; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Targeted Antimicrobial Photochemotherapy Nikolaos S. Soukos, Laurie Ann Ximenez-Fyvie, Michael R. Hamblin, Sigmund S. Socransky, and Tayyaba Hasan Antimicrob. Agents Chemother. October 1998 42: 2595-2601; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiparasitic Effects of the Intra-Golgi Transport Inhibitor Megalomicin Pedro Bonay, Isabel Durán-Chica, Manuel Fresno, Balbino Alarcón, and Antonio Alcina Antimicrob. Agents Chemother. October 1998 42: 2668-2673; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory Activities of Gatifloxacin (AM-1155), a Newly Developed Fluoroquinolone, against Bacterial and Mammalian Type II Topoisomerases Masaya Takei, Hideyuki Fukuda, Tokutaro Yasue, Masaki Hosaka, and Yasuo Oomori Antimicrob. Agents Chemother. October 1998 42: 2678-2681; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Translation Elongation Factor 2 Is Part of the Target for a New Family of Antifungals Laura Capa, Alfonso Mendoza, José L. Lavandera, Federico Gómez de las Heras, and José F. García-Bustos Antimicrob. Agents Chemother. October 1998 42: 2694-2699; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Proteasome Inhibitors Block Development of Plasmodium spp. Soren M. Gantt, Joon Mo Myung, Marcelo R. S. Briones, Wei Dong Li, E. J. Corey, Satoshi Omura, Victor Nussenzweig, and Photini Sinnis Antimicrob. Agents Chemother. October 1998 42: 2731-2738; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Enhancement of Antimicrobial Activity of Neuropeptide Y by N-Terminal Truncation Mayumi Shimizu, Yasushi Shigeri, Yoshiro Tatsu, Susumu Yoshikawa, and Noboru Yumoto Antimicrob. Agents Chemother. October 1998 42: 2745-2746; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Stability of Cephalosporin Prodrug Esters in Human Intestinal Juice: Implications for Oral Bioavailability Klaus Stoeckel, Werner Hofheinz, Jean Paul Laneury, Patrick Duchene, Steve Shedlofsky, and Robert A. Blouin Antimicrob. Agents Chemother. October 1998 42: 2602-2606; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Secretion of Sparfloxacin from the Human Intestinal Caco-2 Cell Line Is Altered by P-Glycoprotein Inhibitors Estelle Cormet-Boyaka, Jean-François Huneau, Agnès Mordrelle, Prosper N. Boyaka, Claude Carbon, Ethan Rubinstein, and Daniel Tomé Antimicrob. Agents Chemother. October 1998 42: 2607-2611; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rifampin Concentrations in Various Compartments of the Human Brain: A Novel Method for Determining Drug Levels in the Cerebral Extracellular Space Thomas Mindermann, Werner Zimmerli, and Otmar Gratzl Antimicrob. Agents Chemother. October 1998 42: 2626-2629; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of a New Cartridge Radioimmunoassay for Determination of Intracellular Levels of Lamivudine Triphosphate in the Peripheral Blood Mononuclear Cells of Human Immunodeficiency Virus-Infected Patients Brian L. Robbins, Thu T. Tran, Frank H. Pinkerton, Jr., Fatima Akeb, Roger Guedj, Jacques Grassi, Danny Lancaster, and Arnold Fridland Antimicrob. Agents Chemother. October 1998 42: 2656-2660; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Compartmental Pharmacokinetics and Tissue Drug Distribution of the Pradimicin Derivative BMS 181184 in Rabbits Andreas H. Groll, Tin Sein, Vidas Petraitis, Ruta Petraitiene, Diana Callender, Corina E. Gonzalez, Neelam Giri, John Bacher, Stephen Piscitelli, and Thomas J. Walsh Antimicrob. Agents Chemother. October 1998 42: 2700-2705; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single-Dose Pharmacokinetics of a Pleconaril (VP63843) Oral Solution and Effect of Food Susan M. Abdel-Rahman and Gregory L. Kearns Antimicrob. Agents Chemother. October 1998 42: 2706-2709; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New Approach for Early Assessment of the Epileptogenic Potential of Quinolones Annie Delon, Claudine Pariat, Philippe Courtois, Serge Bouquet, and William Couet Antimicrob. Agents Chemother. October 1998 42: 2756-2758; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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An Escherichia coli System Expressing Human Deoxyribonucleoside Salvage Enzymes for Evaluation of Potential Antiproliferative Nucleoside Analogs Jianghai Wang, Jan Neuhard, and Staffan Eriksson Antimicrob. Agents Chemother. October 1998 42: 2620-2625; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Apparent Weak Efficacy of Ivermectin for Treatment of Human Toxocariasis Jean-François Magnaval Antimicrob. Agents Chemother. October 1998 42: 2770 [Full Text] [PDF] [Reprints and Permissions]

Inhibitor-Resistant TEM -Lactamases: Revision of the TEM-41 Sequence Roger Labia, El Bachir Chaibi, Danielle Sirot, Catherine Chanal-Claris, Paul Stapleton, Kevin Shannon, and Gary French Antimicrob. Agents Chemother. October 1998 42: 2771 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Energy-Dependent Accumulation of Fluoroquinolones in Quinolone-Resistant Klebsiella pneumoniae Strains Luis Martínez-Martínez, Isabel García, Sofía Ballesta, Vicente Javier Benedí, Santiago Hernández-Allés, and Alvaro Pascual Antimicrob. Agents Chemother. October 1998 42: 2772 [Full Text] [PDF] [Reprints and Permissions]

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Author's Correction:

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Incidence and Mechanisms of Resistance to the Combination of Amoxicillin and Clavulanic Acid in Escherichia coli Paul Stapleton, Pei-Jun Wu, Anna King, Kevin Shannon, Gary French, and Ian Phillips Antimicrob. Agents Chemother. October 1998 42: 2773 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.