Contents: November 1998, Volume 42, Issue 11        Minireviews        Pharmacology        Mechanisms of Resistance        Antiviral Agents        Biologic Response Modifiers        Experimental Therapeutics        Susceptibility        Mechanisms of Action        Clinical Therapeutics        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Resistance to Human Immunodeficiency Virus Type 1 Protease Inhibitors Daniel Boden and Martin Markowitz Antimicrob. Agents Chemother. November 1998 42: 2775-2783; [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacokinetic Interaction between Ritonavir and Indinavir in Healthy Volunteers Ann Hsu, G. Richard Granneman, Guoliang Cao, Lori Carothers, Anthony Japour, Tawakol El-Shourbagy, Suzana Dennis, Jeanne Berg, Keith Erdman, John M. Leonard, and Eugene Sun Antimicrob. Agents Chemother. November 1998 42: 2784-2791; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New Approach to In Vitro Comparisons of Antibiotics in Dynamic Models: Equivalent Area under the Curve/MIC Breakpoints and Equiefficient Doses of Trovafloxacin and Ciprofloxacin against Bacteria of Similar Susceptibilities Alexander A. Firsov, Sergey N. Vostrov, Alexander A. Shevchenko, Yury A. Portnoy, and Stephen H. Zinner Antimicrob. Agents Chemother. November 1998 42: 2841-2847; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

MIC-Based Interspecies Prediction of the Antimicrobial Effects of Ciprofloxacin on Bacteria of Different Susceptibilities in an In Vitro Dynamic Model Alexander A. Firsov, Sergey N. Vostrov, Alexander A. Shevchenko, Stephen H. Zinner, Giuseppe Cornaglia, and Yury A. Portnoy Antimicrob. Agents Chemother. November 1998 42: 2848-2852; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Salmonella typhimurium Infection and Ofloxacin Treatment on Glucose and Glutamine Metabolism in Caco-2/TC-7 Cells Leta Posho, Laurence Delbos-Bocage, Delphine Gueylard, Robert Farinotti, and Claude Carbon Antimicrob. Agents Chemother. November 1998 42: 2950-2955; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intracellular Nucleotides of ()-2',3'-Deoxy-3'-Thiacytidine in Peripheral Blood Mononuclear Cells of a Patient Infected with Human Immunodeficiency Virus Caroline Solas, Yu-Feng Li, Meng-Yu Xie, Jean-Pierre Sommadossi, and Xiao-Jian Zhou Antimicrob. Agents Chemother. November 1998 42: 2989-2995; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penetration of Clindamycin and Its Metabolite N-Demethylclindamycin into Cerebrospinal Fluid following Intravenous Infusion of Clindamycin Phosphate in Patients with AIDS Giorgio Gatti, Marina Malena, Rosetta Casazza, Marie Borin, Matteo Bassetti, and Mario Cruciani Antimicrob. Agents Chemother. November 1998 42: 3014-3017; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Fluoroquinolone Resistance Mutations in the parC, parE, and gyrA Genes of Clinical Isolates of Viridans Group Streptococci Irene González, Marios Georgiou, Fernando Alcaide, Delia Balas, Josefina Liñares, and Adela G. de la Campa Antimicrob. Agents Chemother. November 1998 42: 2792-2798; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gonococcal Resistance to -Lactams and Tetracycline Involves Mutation in Loop 3 of the Porin Encoded at the penB Locus M. J. Gill, S. Simjee, K. Al-Hattawi, B. D. Robertson, C. S. F. Easmon, and C. A. Ison Antimicrob. Agents Chemother. November 1998 42: 2799-2803; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

DNA Gyrase and Topoisomerase IV Are Dual Targets of Clinafloxacin Action in Streptococcus pneumoniae Xiao-Su Pan and L. Mark Fisher Antimicrob. Agents Chemother. November 1998 42: 2810-2816; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Disruption of a Gene Encoding an Autolysin of Enterococcus faecalis OG1RF Xiang Qin, Kavindra V. Singh, Yi Xu, George M. Weinstock, and Barbara E. Murray Antimicrob. Agents Chemother. November 1998 42: 2883-2888; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diversity of Structures Carrying the High-Level Gentamicin Resistance Gene (aac6-aph2) in Enterococcus faecalis Strains Isolated in France Anne Casetta, Annie Buu Hoï, Gilda de Cespédès, and Thea Horaud Antimicrob. Agents Chemother. November 1998 42: 2889-2892; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Display of Functional -Lactamase Inhibitory Protein on the Surface of M13 Bacteriophage Wanzhi Huang, Joseph Petrosino, and Timothy Palzkill Antimicrob. Agents Chemother. November 1998 42: 2893-2897; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in Bartonella bacilliformis gyrB Confer Resistance to Coumermycin A1 James M. Battisti, Laura S. Smitherman, D. Scott Samuels, and Michael F. Minnick Antimicrob. Agents Chemother. November 1998 42: 2906-2913; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Selection of Resistance to Four -Lactams and Azithromycin in Streptococcus pneumoniae Glenn A. Pankuch, Shane A. Jueneman, Todd A. Davies, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. November 1998 42: 2914-2918; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Drift in Susceptibility of Neisseria gonorrhoeae to Ciprofloxacin and Emergence of Therapeutic Failure Catherine A. Ison, Patricia J. Woodford, Helen Madders, and Elizabeth Claydon Antimicrob. Agents Chemother. November 1998 42: 2919-2922; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis Jose L. Lopez-Ribot, Robert K. McAtee, Linda N. Lee, William R. Kirkpatrick, Theodore C. White, Dominique Sanglard, and Thomas F. Patterson Antimicrob. Agents Chemother. November 1998 42: 2932-2937; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluconazole versus Candida albicans: A Complex Relationship John R. Graybill, Eleanor Montalbo, William R. Kirkpatrick, Michael F. Luther, Sanjay G. Revankar, and Thomas F. Patterson Antimicrob. Agents Chemother. November 1998 42: 2938-2942; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Purification and Characterization of Virginiamycin M1 Reductase from Streptomyces virginiae Naoyoshi Suzuki, Chang-Kwon Lee, Takuya Nihira, and Yasuhiro Yamada Antimicrob. Agents Chemother. November 1998 42: 2985-2988; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Erythromycin-Resistant Isolates of Staphylococcus aureus Recovered in the United States from 1958 through 1969 Federico G. Nicola, Linda K. McDougal, James W. Biddle, and Fred C. Tenover Antimicrob. Agents Chemother. November 1998 42: 3024-3027; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinolone Resistance Mutations in the GrlB Protein of Staphylococcus aureus Mayumi Tanaka, Yoshikuni Onodera, Yoko Uchida, and Kenichi Sato Antimicrob. Agents Chemother. November 1998 42: 3044-3046; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Pharmacodynamics of ()--2',3'-Dideoxy-3'-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans Selwyn J. Hurwitz, Bud C. Tennant, Brent E. Korba, John L. Gerin, and Raymond F. Schinazi Antimicrob. Agents Chemother. November 1998 42: 2804-2809; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Epstein-Barr Virus Thymidine Kinase Does Not Phosphorylate Ganciclovir or Acyclovir and Demonstrates a Narrow Substrate Specificity Compared to the Herpes Simplex Virus Type 1 Thymidine Kinase Erik A. Gustafson, Antoinette C. Chillemi, David R. Sage, and Joyce D. Fingeroth Antimicrob. Agents Chemother. November 1998 42: 2923-2931; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Multicenter Phase I/II Dose Escalation Study of Single-Dose Cidofovir Gel for Treatment of Recurrent Genital Herpes Stephen L. Sacks, Stephen D. Shafran, Francisco Diaz-Mitoma, Sylvie Trottier, R. Gary Sibbald, April Hughes, Sharon Safrin, Jeff Rudy, Brian McGuire, and Howard S. Jaffe Antimicrob. Agents Chemother. November 1998 42: 2996-2999; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Coresistance to Zidovudine and Foscarnet Is Associated with Multiple Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gilda Tachedjian, Martyn French, and John Mills Antimicrob. Agents Chemother. November 1998 42: 3038-3043; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Effects of Subinhibitory Concentrations of Antibiotics on Alpha-Toxin (hla) Gene Expression of Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Isolates Knut Ohlsen, Wilma Ziebuhr, Klaus-Peter Koller, Wolfgang Hell, Thomas A. Wichelhaus, and Jörg Hacker Antimicrob. Agents Chemother. November 1998 42: 2817-2823; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Suppression of Murine Endotoxin Response by E5531, a Novel Synthetic Lipid A Antagonist Seiichi Kobayashi, Tsutomu Kawata, Akifumi Kimura, Kaname Miyamoto, Koichi Katayama, Isao Yamatsu, Daniel P. Rossignol, William J. Christ, and Yoshito Kishi Antimicrob. Agents Chemother. November 1998 42: 2824-2829; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Interleukin-10 on Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice Tetsuya Matsumoto, Kazuhiro Tateda, Shuichi Miyazaki, Nobuhiko Furuya, Akira Ohno, Yoshikazu Ishii, Yoichi Hirakata, and Keizo Yamaguchi Antimicrob. Agents Chemother. November 1998 42: 2853-2857; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Efficacy of Teicoplanin and Autoradiographic Diffusion Pattern of [14C]Teicoplanin in Experimental Staphylococcus aureus Infection of Joint Prostheses Azzam Saleh Mghir, Anne Claude Crémieux, Rémy Bleton, Farid Ismael, Michel Manteau, Sophie Dautrey, Laurent Massias, Louis Garry, Nicole Sales, Bernard Mazière, and Claude Carbon Antimicrob. Agents Chemother. November 1998 42: 2830-2835; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Trybizine Hydrochloride against Various Pathogenic Trypanosome Species Ronald Kaminsky and Reto Brun Antimicrob. Agents Chemother. November 1998 42: 2858-2862; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Efficacy Evaluation of Dicationic Carbazole Compounds, Nitazoxanide, and Paromomycin against Cryptosporidium parvum Infections in a Neonatal Mouse Model Byron L. Blagburn, Kathryn L. Drain, Tracey M. Land, Rachel G. Kinard, P. Hutton Moore, David S. Lindsay, Donald A. Patrick, David W. Boykin, and Richard R. Tidwell Antimicrob. Agents Chemother. November 1998 42: 2877-2882; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Efficacy, Safety, and Single-Dose Pharmacokinetics of LY303366, a Novel Echinocandin B, in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits Vidmantas Petraitis, Ruta Petraitiene, Andreas H. Groll, Aaron Bell, Diana P. Callender, Tin Sein, Robert L. Schaufele, Carl L. McMillian, John Bacher, and Thomas J. Walsh Antimicrob. Agents Chemother. November 1998 42: 2898-2905; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Ceftriaxone, Amikacin, and Ciprofloxacin in Treatment of Experimental Yersinia enterocolitica O9 Infection in Mice Maria Jiménez-Valera, Concepción Gonzalez-Torres, Encarnación Moreno, and Alfonso Ruiz-Bravo Antimicrob. Agents Chemother. November 1998 42: 3009-3011; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of Once-Weekly Therapy for Tuberculosis Using Isoniazid plus Rifamycins in the Mouse Aerosol Infection Model Jason V. Brooks and Ian M. Orme Antimicrob. Agents Chemother. November 1998 42: 3047-3048; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Nitazoxanide, a Potential Drug for Eradication of Helicobacter pylori with No Cross-Resistance to Metronidazole Francis Mégraud, Alessandra Occhialini, and Jean François Rossignol Antimicrob. Agents Chemother. November 1998 42: 2836-2840; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sordarins: In Vitro Activities of New Antifungal Derivatives against Pathogenic Yeasts, Pneumocystis carinii, and Filamentous Fungi E. Herreros, C. M. Martinez, M. J. Almela, M. S. Marriott, F. Gomez De Las Heras, and D. Gargallo-Viola Antimicrob. Agents Chemother. November 1998 42: 2863-2869; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antibacterial Activities of OPC-20011, a Novel Parenteral Broad-Spectrum 2-Oxaisocephem Antibiotic Makoto Matsumoto, Hisashi Tamaoka, Hiroshi Ishikawa, and Mikio Kikuchi Antimicrob. Agents Chemother. November 1998 42: 2943-2949; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of New Fluoroquinolones against Fluoroquinolone-Resistant Pathogens of the Lower Respiratory Tract Laura J. V. Piddock, M. Johnson, V. Ricci, and S. L. Hill Antimicrob. Agents Chemother. November 1998 42: 2956-2960; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Specific Activities of Dolastatin 10 and Peptide Derivatives against Cryptococcus neoformans Robin K. Pettit, George R. Pettit, and Kevin C. Hazen Antimicrob. Agents Chemother. November 1998 42: 2961-2965; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bacteriostatic and Bactericidal In Vitro Activities of Clarithromycin and Erythromycin against Periodontopathic Actinobacillus actinomycetemcomitans R. Piccolomini, G. Catamo, and G. Di Bonaventura Antimicrob. Agents Chemother. November 1998 42: 3000-3001; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility of Bacteria Isolated from Orthopedic Implants following Revision Hip Surgery Michael M. Tunney, Gordon Ramage, Sheila Patrick, James R. Nixon, Philip G. Murphy, and Sean P. Gorman Antimicrob. Agents Chemother. November 1998 42: 3002-3005; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pulsed-Exposure and Postantibiotic Leukocyte Enhancement Effects of Amikacin, Clarithromycin, Clofazimine, and Rifampin against Intracellular Mycobacterium avium Lionel Horgen, Arnaud Jerome, and Nalin Rastogi Antimicrob. Agents Chemother. November 1998 42: 3006-3008; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of a New Polyene, SPA-S-843, against Yeasts C. Rimaroli and T. Bruzzese Antimicrob. Agents Chemother. November 1998 42: 3012-3013; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Organism-Dependent Fungicidal Activities of Azoles Elias K. Manavathu, Jessica L. Cutright, and Pranatharthi H. Chandrasekar Antimicrob. Agents Chemother. November 1998 42: 3018-3021; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibilities of Porphyromonas gingivalis, Prevotella intermedia, and Prevotella nigrescens spp. Isolated in Spain María T. Andrés, Whasun O. Chung, Marilyn C. Roberts, and José F. Fierro Antimicrob. Agents Chemother. November 1998 42: 3022-3023; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic Effect and Postantibiotic Sub-MIC Effect of Quinupristin-Dalfopristin against Gram-Positive and -Negative Organisms Glenn A. Pankuch, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. November 1998 42: 3028-3031; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of HMR 3647 Compared to Those of Five Agents against Haemophilus influenzae and Moraxella catarrhalis by MIC Determination and Time-Kill Assay Glenn A. Pankuch, Dianne B. Hoellman, Gengrong Lin, Saralee Bajaksouzian, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. November 1998 42: 3032-3034; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activities of the Pyrrole Derivative BM212 against Multidrug-Resistant and Intramacrophagic Mycobacterium tuberculosis Strains Delia Deidda, Giorgio Lampis, Rossella Fioravanti, Mariangela Biava, Giulio Cesare Porretta, Stefania Zanetti, and Raffaello Pompei Antimicrob. Agents Chemother. November 1998 42: 3035-3037; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Subinhibitory Concentrations of Antimicrobial Agents Reduce the Uptake of Legionella pneumophila into Acanthamoeba castellanii and U937 Cells by Altering the Expression of Virulence-Associated Antigens P. Christian Lück, Jürgen W. Schmitt, Arne Hengerer, and Jürgen H. Helbig Antimicrob. Agents Chemother. November 1998 42: 2870-2876; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Central Role of Hemoglobin Degradation in Mechanisms of Action of 4-Aminoquinolines, Quinoline Methanols, and Phenanthrene Methanols Mathirut Mungthin, Patrick G. Bray, Robert G. Ridley, and Stephen A. Ward Antimicrob. Agents Chemother. November 1998 42: 2973-2977; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluoroquinolone Action against Mycobacteria: Effects of C-8 Substituents on Growth, Survival, and Resistance Yuzhi Dong, Chen Xu, Xilin Zhao, John Domagala, and Karl Drlica Antimicrob. Agents Chemother. November 1998 42: 2978-2984; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Prospective Randomized Comparison of Imipenem-Cilastatin and Piperacillin-Tazobactam in Nosocomial Pneumonia or Peritonitis C. Jaccard, N. Troillet, S. Harbarth, G. Zanetti, D. Aymon, R. Schneider, R. Chiolero, B. Ricou, J. Romand, O. Huber, P. Ambrosetti, G. Praz, D. Lew, J. Bille, M. P. Glauser, and A. Cometta Antimicrob. Agents Chemother. November 1998 42: 2966-2972; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Historical Yearly Usage of Glycopeptides for Animals and Humans: The American-European Paradox Revisited Henrik Caspar Wegener Antimicrob. Agents Chemother. November 1998 42: 3049 [Full Text] [PDF] [Reprints and Permissions]

Revised Sequence of OtrB (Tet347) Tetracycline Efflux Protein from Streptomyces rimosus Laura M. McMurry and Stuart B. Levy Antimicrob. Agents Chemother. November 1998 42: 3050 [Full Text] [PDF] [Reprints and Permissions]

Novel Combination of Mutations in the DNA Gyrase and Topoisomerase IV Genes in Laboratory-Grown Fluoroquinolone-Resistant Shigella flexneri Mutants Yiu-Wai Chu, Elizabeth T. S. Houang, and Augustine F. B. Cheng Antimicrob. Agents Chemother. November 1998 42: 3051-3052; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.