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Mechanisms of Resistance:

Fabio Tosini, Paolo Visca, Ida Luzzi, Anna Maria Dionisi, Cristina Pezzella, Andrea Petrucca, and Alessandra Carattoli

Class 1 Integron-Borne Multiple-Antibiotic Resistance Carried by IncFI and IncL/M Plasmids in Salmonella enterica Serotype Typhimurium
Antimicrob. Agents Chemother. 1998 42: 3053-3058. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Amera Gibreel and Ola Sköld

High-Level Resistance to Trimethoprim in Clinical Isolates of Campylobacter jejuni by Acquisition of Foreign Genes (dfr1 and dfr9) Expressing Drug-Insensitive Dihydrofolate Reductases
Antimicrob. Agents Chemother. 1998 42: 3059-3064. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Renate Franz, Steven L. Kelly, David C. Lamb, Diane E. Kelly, Markus Ruhnke, and Joachim Morschhäuser

Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains
Antimicrob. Agents Chemother. 1998 42: 3065-3072. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marek Gniadkowski and Waleria Hryniewicz

Outbreak of Ceftazidime-Resistant Klebsiella pneumoniae in a Pediatric Hospital in Warsaw, Poland: Clonal Spread of the TEM-47 Extended-Spectrum -Lactamase (ESBL)-Producing Strain and Transfer of a Plasmid Carrying the SHV-5-Like ESBL-Encoding Gene
Antimicrob. Agents Chemother. 1998 42: 3079-3085. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

P. Mugnier, I. Casin, A. T. Bouthors, and E. Collatz

Novel OXA-10-Derived Extended-Spectrum -Lactamases Selected In Vivo or In Vitro
Antimicrob. Agents Chemother. 1998 42: 3113-3116. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Franck Danel, Lucinda M. C. Hall, Deniz Gur, and David M. Livermore

OXA-16, a Further Extended-Spectrum Variant of OXA-10 -Lactamase, from Two Pseudomonas aeruginosa Isolates
Antimicrob. Agents Chemother. 1998 42: 3117-3122. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rama Kishan R. Voladri and Douglas S. Kernodle

Characterization of a Chromosomal Gene Encoding Type B -Lactamase in Phage Group II Isolates of Staphylococcus aureus
Antimicrob. Agents Chemother. 1998 42: 3163-3168. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Arnold S. Bayer, Darwin Cheng, Michael R. Yeaman, G. Ralph Corey, R. Scott McClelland, Lizzie J. Harrel, and Vance G. Fowler, Jr.

In Vitro Resistance to Thrombin-Induced Platelet Microbicidal Protein among Clinical Bacteremic Isolates of Staphylococcus aureus Correlates with an Endovascular Infectious Source
Antimicrob. Agents Chemother. 1998 42: 3169-3172. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Renée A. J. van Boxtel and Jos A. M. van de Klundert

Expression of the Pseudomonas aeruginosa Gentamicin Resistance Gene aacC3 in Escherichia coli
Antimicrob. Agents Chemother. 1998 42: 3173-3178. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Amera Gibreel, Eva Sjögren, Bertil Kaijser, Bengt Wretlind, and Ola Sköld

Rapid Emergence of High-Level Resistance to Quinolones in Campylobacter jejuni Associated with Mutational Changes in gyrA and parC
Antimicrob. Agents Chemother. 1998 42: 3276-3278. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Zhiyu Li, Takashi Deguchi, Mitsuru Yasuda, Takeshi Kawamura, Emiko Kanematsu, Yoshinori Nishino, Satoshi Ishihara, and Yukimichi Kawada

Alteration in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV in Quinolone-Resistant Clinical Isolates of Staphylococcus epidermidis
Antimicrob. Agents Chemother. 1998 42: 3293-3295. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Taimour Yousef Langaee, Michèle Dargis, and Ann Huletsky

An ampD Gene in Pseudomonas aeruginosa Encodes a Negative Regulator of AmpC -Lactamase Expression
Antimicrob. Agents Chemother. 1998 42: 3296-3300. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mark C. Sulavik and Neil L. Barg

Examination of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Mutants with Low-Level Fluoroquinolone Resistance
Antimicrob. Agents Chemother. 1998 42: 3317-3319. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

P. van Langevelde, J. T. van Dissel, E. Ravensbergen, B. J. Appelmelk, I. A. Schrijver, and P. H. P. Groeneveld

Antibiotic-Induced Release of Lipoteichoic Acid and Peptidoglycan from Staphylococcus aureus: Quantitative Measurements and Biological Reactivities
Antimicrob. Agents Chemother. 1998 42: 3073-3078. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Aldona L. Baltch, Raymond P. Smith, Mary A. Franke, and Phyllis B. Michelsen

Antibacterial Effects of Levofloxacin, Erythromycin, and Rifampin in a Human Monocyte System against Legionella pneumophila
Antimicrob. Agents Chemother. 1998 42: 3153-3156. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Steve M. Swaney, Hiroyuki Aoki, M. Clelia Ganoza, and Dean L. Shinabarger

The Oxazolidinone Linezolid Inhibits Initiation of Protein Synthesis in Bacteria
Antimicrob. Agents Chemother. 1998 42: 3251-3255. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Timothy J. Falla and Ian Chopra

Joint Tolerance to -Lactam and Fluoroquinolone Antibiotics in Escherichia coli Results from Overexpression of hipA
Antimicrob. Agents Chemother. 1998 42: 3282-3284. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Clinical Therapeutics:

Andreas Stein, Jean Francois Bataille, Michel Drancourt, Georges Curvale, Jean Noel Argenson, Pierre Groulier, and Didier Raoult

Ambulatory Treatment of Multidrug-Resistant Staphylococcus-Infected Orthopedic Implants with High-Dose Oral Co-trimoxazole (Trimethoprim-Sulfamethoxazole)
Antimicrob. Agents Chemother. 1998 42: 3086-3091. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mary J. Camp, John R. Wingard, Claire E. Gilmore, Lillian S. Lin, Suzanne P. Dix, Terry G. Davidson, and Robert B. Geller

Efficacy of Low-Dose Dopamine in Preventing Amphotericin B Nephrotoxicity in Bone Marrow Transplant Patients and Leukemia Patients
Antimicrob. Agents Chemother. 1998 42: 3103-3106. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jirô Arata, Takeshi Horio, Rinzo Soejima, and Kenji Ohara

Photosensitivity Reactions Caused by Lomefloxacin Hydrochloride: A Multicenter Survey
Antimicrob. Agents Chemother. 1998 42: 3141-3145. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Shoshana Frankenburg, Dvora Glick, Sidney Klaus, and Yechezkel Barenholz

Efficacious Topical Treatment for Murine Cutaneous Leishmaniasis with Ethanolic Formulations of Amphotericin B
Antimicrob. Agents Chemother. 1998 42: 3092-3096. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Valerie Berry, Christine E. Thorburn, Sarah J. Knott, and Gary Woodnutt

Bacteriological Efficacies of Three Macrolides Compared with Those of Amoxicillin-Clavulanate against Streptococcus pneumoniae and Haemophilus influenzae
Antimicrob. Agents Chemother. 1998 42: 3193-3199. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Olivier Mimoz, Anne Jacolot, Sophie Leotard, Nadia Hidri, Kamran Samii, Patrice Nordmann, and Olivier Petitjean

Efficacies of Cefepime, Ceftazidime, and Imipenem Alone or in Combination with Amikacin in Rats with Experimental Pneumonia Due to Ceftazidime-Susceptible or -Resistant Enterobacter cloacae Strains
Antimicrob. Agents Chemother. 1998 42: 3304-3308. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Young S. Kim, Quingxiang Liu, Lucien L. Chow, Henry F. Chambers, and Martin G. Täuber

Comparative Efficacy of Trovafloxacin in Experimental Endocarditis Caused by Ciprofloxacin-Sensitive, Methicillin-Resistant Staphylococcus aureus
Antimicrob. Agents Chemother. 1998 42: 3325-3327. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

D. Sereno, M. Cavaleyra, K. Zemzoumi, S. Maquaire, A. Ouaissi, and J. L. Lemesre

Axenically Grown Amastigotes of Leishmania infantum Used as an In Vitro Model To Investigate the Pentavalent Antimony Mode of Action
Antimicrob. Agents Chemother. 1998 42: 3097-3102. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

M. A. Pfaller, S. A. Messer, R. J. Hollis, R. N. Jones, G. V. Doern, M. E. Brandt, and R. A. Hajjeh

In Vitro Susceptibilities of Candida Bloodstream Isolates to the New Triazole Antifungal Agents BMS-207147, Sch 56592, and Voriconazole
Antimicrob. Agents Chemother. 1998 42: 3242-3244. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Frederick S. Buckner, Aaron J. Wilson, Theodore C. White, and Wesley C. Van Voorhis

Induction of Resistance to Azole Drugs in Trypanosoma cruzi
Antimicrob. Agents Chemother. 1998 42: 3245-3250. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

C. Torres, M. Zarazaga, C. Tenorio, A. Portillo, Y. Saenz, F. Ruiz, and F. Baquero

In Vitro Activity of the New Ketolide HMR3647 in Comparison with Those of Macrolides and Pristinamycins against Enterococcus spp.
Antimicrob. Agents Chemother. 1998 42: 3279-3281. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Luis Martínez-Martínez, Alvaro Pascual, Ana Isabel Suárez, and Evelio J. Perea

In Vitro Activities of Ketolide HMR 3647, Macrolides, and Clindamycin against Coryneform Bacteria
Antimicrob. Agents Chemother. 1998 42: 3290-3292. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Olivier Ridoux and Michel Drancourt

In Vitro Susceptibilities of the Microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to Albendazole and Its Sulfoxide and Sulfone Metabolites
Antimicrob. Agents Chemother. 1998 42: 3301-3303. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Patricia A. Hogan and Daniel J. Sheehan

Macrolide Susceptibility and -Lactamase Production among Haemophilus influenzae Isolates in the United States, 1996-1997
Antimicrob. Agents Chemother. 1998 42: 3313-3314. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Carolyn M. Shoen, Olga Choromanska, Robert C. Reynolds, James R. Piper, Cheryl A. Johnson, and Michael H. Cynamon

In Vitro Activities of Several Diaminomethylpyridopyrimidines against Mycobacterium avium Complex
Antimicrob. Agents Chemother. 1998 42: 3315-3316. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

A. Giacometti, O. Cirioni, G. Greganti, M. Quarta, and G. Scalise

In Vitro Activities of Membrane-Active Peptides against Gram-Positive and Gram-Negative Aerobic Bacteria
Antimicrob. Agents Chemother. 1998 42: 3320-3324. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Daniele Ouellet, Ann Hsu, Jiang Qian, Janet E. Lamm, John H. Cavanaugh, John M. Leonard, and G. Richard Granneman

Effect of Fluoxetine on Pharmacokinetics of Ritonavir
Antimicrob. Agents Chemother. 1998 42: 3107-3112. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Saori Kojima, Masayuki Nadai, Kiyoyuki Kitaichi, Li Wang, Toshitaka Nabeshima, and Takaaki Hasegawa

Possible Mechanism by Which the Carbapenem Antibiotic Panipenem Decreases the Concentration of Valproic Acid in Plasma in Rats
Antimicrob. Agents Chemother. 1998 42: 3136-3140. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kishor M. Wasan, Allison L. Kennedy, Shawn M. Cassidy, Manisha Ramaswamy, Lorilynne Holtorf, Jenny Wen-Lin Chou, and P. Haydn Pritchard

Pharmacokinetics, Distribution in Serum Lipoproteins and Tissues, and Renal Toxicities of Amphotericin B and Amphotericin B Lipid Complex in a Hypercholesterolemic Rabbit Model: Single-Dose Studies
Antimicrob. Agents Chemother. 1998 42: 3146-3152. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

P. C. Scholten, R. M. Droppert, M. G. J. Zwinkels, H. L. Moesker, J. J. P. Nauta, and I. M. Hoepelman

No Interaction between Ciprofloxacin and an Oral Contraceptive
Antimicrob. Agents Chemother. 1998 42: 3266-3268. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Veronica Miller, Marie-Pierre de Béthune, Astrid Kober, Martin Stürmer, Kurt Hertogs, Rudi Pauwels, Paul Stoffels, and Schlomo Staszewski

Patterns of Resistance and Cross-Resistance to Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors in Patients Treated with the Nonnucleoside Reverse Transcriptase Inhibitor Loviride
Antimicrob. Agents Chemother. 1998 42: 3123-3129. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

A. J. Nicoll, D. L. Colledge, J. J. Toole, P. W. Angus, R. A. Smallwood, and S. A. Locarnini

Inhibition of Duck Hepatitis B Virus Replication by 9-(2-Phosphonylmethoxyethyl)adenine, an Acyclic Phosphonate Nucleoside Analogue
Antimicrob. Agents Chemother. 1998 42: 3130-3135. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ranga V. Srinivas, David Middlemas, Pat Flynn, and Arnold Fridland

Human Immunodeficiency Virus Protease Inhibitors Serve as Substrates for Multidrug Transporter Proteins MDR1 and MRP1 but Retain Antiviral Efficacy in Cell Lines Expressing These Transporters
Antimicrob. Agents Chemother. 1998 42: 3157-3162. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Robert W. King, Stephanie K. Ladner, Thomas J. Miller, Katie Zaifert, Robert B. Perni, Sameul C. Conway, and Michael J. Otto

Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with ()-L-2',3'-Dideoxy-3'-Thiacytidine
Antimicrob. Agents Chemother. 1998 42: 3179-3186. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Brigitta U. Mueller, Linda L. Lewis, Geoffrey J. Yuen, Maureen Farley, Amy Keller, Joseph A. Church, Jonathan C. Goldsmith, David J. Venzon, Marc Rubin, Philip A. Pizzo, and Frank M. Balis

Serum and Cerebrospinal Fluid Pharmacokinetics of Intravenous and Oral Lamivudine in Human Immunodeficiency Virus-Infected Children
Antimicrob. Agents Chemother. 1998 42: 3187-3192. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Maria Seifer, Robert K. Hamatake, Richard J. Colonno, and David N. Standring

In Vitro Inhibition of Hepadnavirus Polymerases by the Triphosphates of BMS-200475 and Lobucavir
Antimicrob. Agents Chemother. 1998 42: 3200-3208. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

E. V. Genovesi, L. Lamb, I. Medina, D. Taylor, M. Seifer, S. Innaimo, R. J. Colonno, D. N. Standring, and J. M. Clark

Efficacy of the Carbocyclic 2'-Deoxyguanosine Nucleoside BMS-200475 in the Woodchuck Model of Hepatitis B Virus Infection
Antimicrob. Agents Chemother. 1998 42: 3209-3217. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hing L. Sham, Dale J. Kempf, Akhteruzammen Molla, Kennan C. Marsh, Gondi N. Kumar, Chih-Ming Chen, Warren Kati, Kent Stewart, Ritu Lal, Ann Hsu, David Betebenner, Marina Korneyeva, Sudthida Vasavanonda, Edith McDonald, Ayda Saldivar, Norm Wideburg, Xiaoqi Chen, Ping Niu, Chang Park, Venkata Jayanti, Brian Grabowski, G. Richard Granneman, Eugene Sun, Anthony J. Japour, John M. Leonard, Jacob J. Plattner, and Daniel W. Norbeck

ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease
Antimicrob. Agents Chemother. 1998 42: 3218-3224. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Elise A. Sudbeck, Chen Mao, Rakesh Vig, T. K. Venkatachalam, Lisa Tuel-Ahlgren, and Fatih M. Uckun

Structure-Based Design of Novel Dihydroalkoxybenzyloxopyrimidine Derivatives as Potent Nonnucleoside Inhibitors of the Human Immunodeficiency Virus Reverse Transcriptase
Antimicrob. Agents Chemother. 1998 42: 3225-3233. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chun Y. Tai, Paul A. Escarpe, Robert W. Sidwell, Matthew A. Williams, Willard Lew, Huiwei Wu, Choung U. Kim, and Dirk B. Mendel

Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071
Antimicrob. Agents Chemother. 1998 42: 3234-3241. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laurence Melnick, Shiow-Shong Yang, Rick Rossi, Charlie Zepp, and Donald Heefner

An Escherichia coli Expression Assay and Screen for Human Immunodeficiency Virus Protease Variants with Decreased Susceptibility to Indinavir
Antimicrob. Agents Chemother. 1998 42: 3256-3265. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Johan Neyts, Graciela Andrei, and Erik De Clercq

The Antiherpesvirus Activity of H2G [(R)-9-[4-Hydroxy-2-(Hydroxymethyl)Butyl]Guanine] Is Markedly Enhanced by the Novel Immunosuppressive Agent Mycophenolate Mofetil
Antimicrob. Agents Chemother. 1998 42: 3285-3289. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

Teiji Sawa, Kiyoyasu Kurahashi, Maria Ohara, Michael A. Gropper, Vatsal Doshi, James W. Larrick, and Jeanine P. Wiener-Kronish

Evaluation of Antimicrobial and Lipopolysaccharide-Neutralizing Effects of a Synthetic CAP18 Fragment against Pseudomonas aeruginosa in a Mouse Model
Antimicrob. Agents Chemother. 1998 42: 3269-3275. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michel Duong, Marie Simard, Yves Bergeron, Nathalie Ouellet, Mélanie Côté-Richer, and Michel G. Bergeron

Immunomodulating Effects of HMR 3004 on Pulmonary Inflammation Caused by Heat-Killed Streptococcus pneumoniae in Mice
Antimicrob. Agents Chemother. 1998 42: 3309-3312. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Geert Claeys, Thierry De Baere, Mario Vaneechoutte, and Gerda Verschraegen

Caz-hi, an Extended-Spectrum TEM -Lactamase (TEM-61), Is Derived from Caz-lo (TEM-11) by In Vivo Selection
Antimicrob. Agents Chemother. 1998 42: 3328. [Full Text] [PDF] [Reprints and Permissions]  

Lars Bogø Jensen, Anette M. Hammerum, Frank M. Aarestrup, Anthony E. van den Bogaard, and Ellen E. Stobberingh

Occurrence of satA and vgb Genes in Streptogramin-Resistant Enterococcus faecium Isolates of Animal and Human Origins in The Netherlands
Antimicrob. Agents Chemother. 1998 42: 3330-3331. [Full Text] [PDF] [Reprints and Permissions]  

Lars-Olof Hattenbach, Hermann Gümbel, and Stefan Kippenberger

Identification of Beta-Defensins in Human Conjunctiva
Antimicrob. Agents Chemother. 1998 42: 3332. [Full Text] [PDF] [Reprints and Permissions]  

H. Yoshimura, M. Ishimaru, Y. S. Endoh, M. Suginaka, and S. Yamatani

Isolation of Glycopeptide-Resistant Enterococci from Chickens in Japan
Antimicrob. Agents Chemother. 1998 42: 3333. [Full Text] [PDF] [Reprints and Permissions]  

Robert H. Gelber;, Baohong Ji, and Jacques H. Grosset

Another View of the Therapy of Leprosy
Antimicrob. Agents Chemother. 1998 42: 3334-3336. [Full Text] [PDF] [Reprints and Permissions]  

Errata:

Selwyn J. Hurwitz, Bud C. Tennant, Brent E. Korba, John L. Gerin, and Raymond F. Schinazi

Pharmacodynamics of ()--2',3'-Dideoxy-3'-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans
Antimicrob. Agents Chemother. 1998 42: 3337. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.