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Mechanisms of Resistance:

Isabelle Casin, Florence Bordon, Philippe Bertin, Anne Coutrot, Isabelle Podglajen, Robert Brasseur, and Ekkehard Collatz

Aminoglycoside 6'-N-Acetyltransferase Variants of the Ib Type with Altered Substrate Profile in Clinical Isolates of Enterobacter cloacae and Citrobacter freundii
Antimicrob. Agents Chemother. 1998 42: 209-215. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ana M. Amoroso and Gabriel O. Gutkind

Chromogenic Detection of Aminoglycoside Phosphotransferases
Antimicrob. Agents Chemother. 1998 42: 228-230. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tong Wang, Mayumi Tanaka, and Kenichi Sato

Detection of grlA and gyrA Mutations in 344 Staphylococcus aureus Strains
Antimicrob. Agents Chemother. 1998 42: 236-240. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Dominique Sanglard, Françoise Ischer, Luc Koymans, and Jacques Bille

Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents
Antimicrob. Agents Chemother. 1998 42: 241-253. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Helena Seppälä, Mikael Skurnik, Hanna Soini, Marilyn C. Roberts, and Pentti Huovinen

A Novel Erythromycin Resistance Methylase Gene (ermTR) in Streptococcus pyogenes
Antimicrob. Agents Chemother. 1998 42: 257-262. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Paul D. Fey, Michael W. Climo, and Gordon L. Archer

Determination of the Chromosomal Relationship between mecA and gyrA in Methicillin-Resistant Coagulase-Negative Staphylococci
Antimicrob. Agents Chemother. 1998 42: 306-312. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Nicolas Mbongo, Philippe M. Loiseau, Marie A. Billion, and Malka Robert-Gero

Mechanism of Amphotericin B Resistance in Leishmania donovani Promastigotes
Antimicrob. Agents Chemother. 1998 42: 352-357. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Herbert P. Schweizer

Intrinsic Resistance to Inhibitors of Fatty Acid Biosynthesis in Pseudomonas aeruginosa Is Due to Efflux: Application of a Novel Technique for Generation of Unmarked Chromosomal Mutations for the Study of Efflux Systems
Antimicrob. Agents Chemother. 1998 42: 394-398. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Xian-Zhi Li, Li Zhang, Ramakrishnan Srikumar, and Keith Poole

-Lactamase Inhibitors Are Substrates for the Multidrug Efflux Pumps of Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 1998 42: 399-403. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Emiko Kanematsu, Takashi Deguchi, Mitsuru Yasuda, Takeshi Kawamura, Yoshinori Nishino, and Yukimichi Kawada

Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV Associated with Quinolone Resistance in Enterococcus faecalis
Antimicrob. Agents Chemother. 1998 42: 433-435. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

T. R. Walsh, W. A. Neville, M. H. Haran, D. Tolson, D. J. Payne, J. H. Bateson, A. P. Macgowan, and P. M. Bennett

Nucleotide and Amino Acid Sequences of the Metallo--Lactamase, ImiS, from Aeromonas veronii bv. sobria
Antimicrob. Agents Chemother. 1998 42: 436-439. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anna Marchese, Guillaume Arlet, Gian Carlo Schito, Philippe H. Lagrange, and Alain Philippon

Characterization of FOX-3, an AmpC-Type Plasmid-Mediated -Lactamase from an Italian Isolate of Klebsiella oxytoca
Antimicrob. Agents Chemother. 1998 42: 464-467. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Bernadette A. Mitchell, Melissa H. Brown, and Ronald A. Skurray

QacA Multidrug Efflux Pump from Staphylococcus aureus: Comparative Analysis of Resistance to Diamidines, Biguanidines, and Guanylhydrazones
Antimicrob. Agents Chemother. 1998 42: 475-477. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Johan Neyts, Graciela Andrei, and Erik De Clercq

The Novel Immunosuppressive Agent Mycophenolate Mofetil Markedly Potentiates the Antiherpesvirus Activities of Acyclovir, Ganciclovir, and Penciclovir In Vitro and In Vivo
Antimicrob. Agents Chemother. 1998 42: 216-222. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

S. De Wit, M. Debier, M. De Smet, J. McCrea, J. Stone, A. Carides, C. Matthews, P. Deutsch, and N. Clumeck

Effect of Fluconazole on Indinavir Pharmacokinetics in Human Immunodeficiency Virus-Infected Patients
Antimicrob. Agents Chemother. 1998 42: 223-227. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kurt Hertogs, Marie-Pierre de Béthune, Veronica Miller, Tania Ivens, Patricia Schel, Anja Van Cauwenberge, Christel Van den Eynde, Veerle van Gerwen, Hilde Azijn, Margriet van Houtte, Frank Peeters, Schlomo Staszewski, Marcus Conant, Stuart Bloor, Sharon Kemp, Brendan Larder, and Rudi Pauwels

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs
Antimicrob. Agents Chemother. 1998 42: 269-276. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Faruq H. Noormohamed, Michael S. Youle, Christopher J. Higgs, Sarah Martin-Munley, Brian G. Gazzard, and Ariel F. Lant

Pharmacokinetics and Absolute Bioavailability of Oral Foscarnet in Human Immunodeficiency Virus-Seropositive Patients
Antimicrob. Agents Chemother. 1998 42: 293-297. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kuang C. Yeh, Paul J. Deutsch, Heidi Haddix, Michael Hesney, Vicki Hoagland, William D. Ju, Steven J. Justice, Barbara Osborne, Andrew T. Sterrett, Julie A. Stone, Eric Woolf, and Scott Waldman

Single-Dose Pharmacokinetics of Indinavir and the Effect of Food
Antimicrob. Agents Chemother. 1998 42: 332-338. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Stéphanie Aguesse-Germon, Shwu-Huey Liu, Michèle Chevallier, Christian Pichoud, Catherine Jamard, Christelle Borel, Chung K. Chu, Christian Trépo, Yung-Chi Cheng, and Fabien Zoulim

Inhibitory Effect of 2'-Fluoro-5-Methyl--L-Arabinofuranosyl-Uracil on Duck Hepatitis B Virus Replication
Antimicrob. Agents Chemother. 1998 42: 369-376. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Fatih M. Uckun, Lisa M. Chelstrom, Lisa Tuel-Ahlgren, Ilker Dibirdik, James D. Irvin, Mridula-Chandan Langlie, and Dorothea E. Myers

TXU (Anti-CD7)-Pokeweed Antiviral Protein as a Potent Inhibitor of Human Immunodeficiency Virus
Antimicrob. Agents Chemother. 1998 42: 383-388. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

John M. Adams, Mark J. Shelton, Ross G. Hewitt, Mary DeRemer, Robin DiFrancesco, Thaddeus H. Grasela, and Gene D. Morse

Zalcitabine Population Pharmacokinetics: Application of Radioimmunoassay
Antimicrob. Agents Chemother. 1998 42: 409-413. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Fausto Baldanti, Mark R. Underwood, Christine L. Talarico, Lavinia Simoncini, Antonella Sarasini, Karen K. Biron, and Giuseppe Gerna

The Cys607Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients
Antimicrob. Agents Chemother. 1998 42: 444-446. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Paul L. Boyer, Hong-Qiang Gao, and Stephen H. Hughes

A Mutation at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Interacts with Mutations at Positions 74 and 75 via the Template Primer
Antimicrob. Agents Chemother. 1998 42: 447-452. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Simon P. Tucker, Thomas R. Stiebel, Jr., Karen E. Potts, Mary L. Smidt, and Martin L. Bryant

Estimate of the Frequency of Human Immunodeficiency Virus Type 1 Protease Inhibitor Resistance within Unselected Virus Populations In Vitro
Antimicrob. Agents Chemother. 1998 42: 478-480. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Kenneth C. Lamp and Mary K. Vickers

Pharmacodynamics of Ampicillin-Sulbactam in an In Vitro Infection Model against Escherichia coli Strains with Various Levels of Resistance
Antimicrob. Agents Chemother. 1998 42: 231-235. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Garry W. Boswell, Ihor Bekersky, Donald Buell, Richard Hiles, and Thomas J. Walsh

Toxicological Profile and Pharmacokinetics of a Unilamellar Liposomal Vesicle Formulation of Amphotericin B in Rats
Antimicrob. Agents Chemother. 1998 42: 263-268. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

K. Stuertz, H. Schmidt, H. Eiffert, P. Schwartz, M. Mäder, and R. Nau

Differential Release of Lipoteichoic and Teichoic Acids from Streptococcus pneumoniae as a Result of Exposure to -Lactam Antibiotics, Rifamycins, Trovafloxacin, and Quinupristin-Dalfopristin
Antimicrob. Agents Chemother. 1998 42: 277-281. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

B. Nouaille-Degorce, C. Veau, S. Dautrey, M. Tod, D. Laouari, C. Carbon, and R. Farinotti

Influence of Renal Failure on Ciprofloxacin Pharmacokinetics in Rats
Antimicrob. Agents Chemother. 1998 42: 289-292. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rémi Forrat, Rafaele Dumas, Michael Seiberling, Michael Merz, Charles Lutsch, and Jean Lang

Evaluation of the Safety and Pharmacokinetic Profile of a New, Pasteurized, Human Tetanus Immunoglobulin Administered as Sham, Postexposure Prophylaxis of Tetanus
Antimicrob. Agents Chemother. 1998 42: 298-305. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tomoo Itoh, Naoko Watanabe, Mariko Ishida, Yasuyuki Tsuda, Shinichi Koyano, Tomoko Tsunoi, Hideyo Shimada, and Hideo Yamada

Stereoselective Disposition of Sulbenicillin in Humans
Antimicrob. Agents Chemother. 1998 42: 325-331. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

George L. Drusano and Daniel S. Stein

Mathematical Modeling of the Interrelationship of CD4 Lymphocyte Count and Viral Load Changes Induced by the Protease Inhibitor Indinavir
Antimicrob. Agents Chemother. 1998 42: 358-361. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Louis de Repentigny, Johanne Ratelle, Jean-Marie Leclerc, Guy Cornu, Étienne M. Sokal, Philippe Jacqmin, and Karel de Beule

Repeated-Dose Pharmacokinetics of an Oral Solution of Itraconazole in Infants and Children
Antimicrob. Agents Chemother. 1998 42: 404-408. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

F. Fuentes, J. Izquierdo, M. M. Martín, M. L. Gomez-Lus, and J. Prieto

Postantibiotic and Sub-MIC Effects of Azithromycin and Isepamicin against Staphylococcus aureus and Escherichia coli
Antimicrob. Agents Chemother. 1998 42: 414-418. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Bernadette Jacoberger, Genevieve Ubeaud, Guy Freys, Thierry Pottecher, Louis Jung, and Jean Claude Koffel

Concentrations of Pefloxacin in Plasma and Tissue after Administration as Surgical Prophylaxis
Antimicrob. Agents Chemother. 1998 42: 425-427. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

R. Wise, S. Jones, I. Das, and J. M. Andrews

Pharmacokinetics and Inflammatory Fluid Penetration of Clinafloxacin
Antimicrob. Agents Chemother. 1998 42: 428-430. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Rumiko Minami, Chizuko Nakamura, Nobuo Inotsume, and Masahiro Nakano

Effects of Aluminum Hydroxide and Famotidine on Bioavailability of Tosufloxacin in Healthy Volunteers
Antimicrob. Agents Chemother. 1998 42: 453-455. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Edward F. Foote and Charles E. Halstenson

Effects of Probenecid and Cimetidine on Renal Disposition of Ofloxacin in Rats
Antimicrob. Agents Chemother. 1998 42: 456-458. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Albert Musafija, Asher Barzilai, Jacob Ramon, and Ethan Rubinstein

Effect of Cholera Toxin on Intestinal Elimination of Ciprofloxacin in Rabbits
Antimicrob. Agents Chemother. 1998 42: 473-474. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Glenn W. Kaatz, Susan M. Seo, Jeffrey R. Aeschlimann, Heather H. Houlihan, Reneé-Claude Mercier, and Michael J. Rybak

Efficacy of Trovafloxacin against Experimental Staphylococcus aureus Endocarditis
Antimicrob. Agents Chemother. 1998 42: 254-256. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

F. C. Odds, F. Van Gerven, A. Espinel-Ingroff, M. S. Bartlett, M. A. Ghannoum, M. V. Lancaster, M. A. Pfaller, J. H. Rex, M. G. Rinaldi, and T. J. Walsh

Evaluation of Possible Correlations between Antifungal Susceptibilities of Filamentous Fungi In Vitro and Antifungal Treatment Outcomes in Animal Infection Models
Antimicrob. Agents Chemother. 1998 42: 282-288. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Goutam Banerjee, Swapna Medda, and Mukul K. Basu

A Novel Peptide-Grafted Liposomal Delivery System Targeted to Macrophages
Antimicrob. Agents Chemother. 1998 42: 348-351. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Edward B. Breitschwerdt, Barbara C. Hegarty, and Susan I. Hancock

Doxycycline Hyclate Treatment of Experimental Canine Ehrlichiosis Followed by Challenge Inoculation with Two Ehrlichia canis Strains
Antimicrob. Agents Chemother. 1998 42: 362-368. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jan G. den Hollander, Jenny D. Knudsen, Johan W. Mouton, Kurt Fuursted, Niels Frimodt-Møller, Henri A. Verbrugh, and Frank Espersen

Comparison of Pharmacodynamics of Azithromycin and Erythromycin In Vitro and In Vivo
Antimicrob. Agents Chemother. 1998 42: 377-382. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

S. Leitzke, W. Bucke, K. Borner, R. Müller, H. Hahn, and S. Ehlers

Rationale for and Efficacy of Prolonged-Interval Treatment Using Liposome-Encapsulated Amikacin in Experimental Mycobacterium avium Infection
Antimicrob. Agents Chemother. 1998 42: 459-461. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Olivier Join-Lambert, Jean-Luc Mainardi, Catherine Cuvelier, Sophie Dautrey, Robert Farinotti, Bruno Fantin, and Claude Carbon

Critical Importance of In Vivo Amoxicillin and Cefotaxime Concentrations for Synergy in Treatment of Experimental Enterococcus faecalis Endocarditis
Antimicrob. Agents Chemother. 1998 42: 468-470. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Joan C. Fung-Tomc, Elizabeth Huczko, Beatrice Minassian, and Daniel P. Bonner

In Vitro Activity of a New Oral Triazole, BMS-207147 (ER-30346)
Antimicrob. Agents Chemother. 1998 42: 313-318. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lieke V. M. Möller, Annette G. Regelink, Henny Grasselier, Loek van Alphen, and Jacob Dankert

Antimicrobial Susceptibility of Haemophilus influenzae in the Respiratory Tracts of Patients with Cystic Fibrosis
Antimicrob. Agents Chemother. 1998 42: 319-324. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

L. A. Collins, M. N. Torrero, and S. G. Franzblau

Green Fluorescent Protein Reporter Microplate Assay for High-Throughput Screening of Compounds against Mycobacterium tuberculosis
Antimicrob. Agents Chemother. 1998 42: 344-347. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

A. P. MacGowan, K. E. Bowker, M. Wootton, H. A. Holt, and D. S. Reeves

In Vitro Activities of Y-688, a New 7-Substituted Fluoroquinolone, against Anaerobic Bacteria
Antimicrob. Agents Chemother. 1998 42: 419-424. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Isami Tsuboi, Hirohisa Ida, Eiji Yoshikawa, Suehiro Hiyoshi, Emiko Yamaji, Issei Nakayama, Tomoko Nonomiya, Fritz Shigenobu, Masaki Shimizu, Koji O'Hara, Tetsuo Sawai, and Keiji Mizuoka

Antibiotic Susceptibility of Enterohemorrhagic Escherichia coli O157:H7 Isolated from an Outbreak in Japan in 1996
Antimicrob. Agents Chemother. 1998 42: 431-432. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yiu-wai Chu, Elizabeth T. S. Houang, Donald J. Lyon, Julia M. Ling, Tak-keung Ng, and Augustine F. B. Cheng

Antimicrobial Resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995
Antimicrob. Agents Chemother. 1998 42: 440-443. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Michael H. Cynamon, Robert J. Speirs, and John T. Welch

In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide
Antimicrob. Agents Chemother. 1998 42: 462-463. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

M. Hong Nguyen and Christine Y. Yu

In Vitro Comparative Efficacy of Voriconazole and Itraconazole against Fluconazole-Susceptible and -Resistant Cryptococcus neoformans Isolates
Antimicrob. Agents Chemother. 1998 42: 471-472. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chemistry; Biosynthesis:

John W. Benbow, Erin L. Bernberg, Anna Korda, and Jan R. Mead

Synthesis and Evaluation of Dinitroanilines for Treatment of Cryptosporidiosis
Antimicrob. Agents Chemother. 1998 42: 339-343. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

John O. Capobianco, Dorothy Zakula, David J. Frost, Robert C. Goldman, Leping Li, Larry L. Klein, and Paul A. Lartey

Cellular Accumulation, Localization, and Activity of a Synthetic Cyclopeptamine in Fungi
Antimicrob. Agents Chemother. 1998 42: 389-393. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letters:

Angela D. M. Kashuba, Guy W. Amsden;, K. B. Patel, D. Xuan, P. R. Tessier, R. Quintiliani, and C. H. Nightingale

Bronchopulmonary Pharmacokinetics of Clarithromycin and Azithromycin
Antimicrob. Agents Chemother. 1998 42: 481-482. [Full Text] [PDF] [Reprints and Permissions]  

Raymond Vanhoof, Eleonora Hannecart-Pokorni, and Jean Content

Nomenclature of Genes Encoding Aminoglycoside-Modifying Enzymes
Antimicrob. Agents Chemother. 1998 42: 483. [Full Text] [PDF] [Reprints and Permissions]  

Errata:

Haluk Vahaboglu, Recep Öztürk, Gökhan Aygün, Akgün Yaman, Arif Kaygusuz, Hakan Leblebicioglu, Kemalettin Aydin, and Metin Otkun

Widespread Detection of PER-1-Type Extended-Spectrum -Lactamases among Nosocomial Acinetobacter and Pseudomonas aeruginosa Isolates in Turkey: a Nationwide Multicenter Study
Antimicrob. Agents Chemother. 1998 42: 484. [Full Text] [PDF] [Reprints and Permissions]  

Author's Correction:

Eleonora Hannecart-Pokorni, Freddy Depuydt, Lucas De Wit, Eddie Van Bossuyt, Jean Content, and Raymond Vanhoof

Characterization of the 6'-N-Aminoglycoside Acetyltransferase Gene aac(6')-Il Associated with a sulI-Type Integron
Antimicrob. Agents Chemother. 1998 42: 485. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.