Contents: February 1998, Volume 42, Issue 2        Mechanisms of Resistance        Antiviral Agents        Pharmacology        Experimental Therapeutics        Susceptibility        Chemistry; Biosynthesis        Mechanisms of Action        Letters        Errata        Author's Correction Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Mechanisms of Resistance:

---

Aminoglycoside 6'-N-Acetyltransferase Variants of the Ib Type with Altered Substrate Profile in Clinical Isolates of Enterobacter cloacae and Citrobacter freundii Isabelle Casin, Florence Bordon, Philippe Bertin, Anne Coutrot, Isabelle Podglajen, Robert Brasseur, and Ekkehard Collatz Antimicrob. Agents Chemother. February 1998 42: 209-215; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chromogenic Detection of Aminoglycoside Phosphotransferases Ana M. Amoroso and Gabriel O. Gutkind Antimicrob. Agents Chemother. February 1998 42: 228-230; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of grlA and gyrA Mutations in 344 Staphylococcus aureus Strains Tong Wang, Mayumi Tanaka, and Kenichi Sato Antimicrob. Agents Chemother. February 1998 42: 236-240; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents Dominique Sanglard, Françoise Ischer, Luc Koymans, and Jacques Bille Antimicrob. Agents Chemother. February 1998 42: 241-253; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Erythromycin Resistance Methylase Gene (ermTR) in Streptococcus pyogenes Helena Seppälä, Mikael Skurnik, Hanna Soini, Marilyn C. Roberts, and Pentti Huovinen Antimicrob. Agents Chemother. February 1998 42: 257-262; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Determination of the Chromosomal Relationship between mecA and gyrA in Methicillin-Resistant Coagulase-Negative Staphylococci Paul D. Fey, Michael W. Climo, and Gordon L. Archer Antimicrob. Agents Chemother. February 1998 42: 306-312; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Amphotericin B Resistance in Leishmania donovani Promastigotes Nicolas Mbongo, Philippe M. Loiseau, Marie A. Billion, and Malka Robert-Gero Antimicrob. Agents Chemother. February 1998 42: 352-357; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Intrinsic Resistance to Inhibitors of Fatty Acid Biosynthesis in Pseudomonas aeruginosa Is Due to Efflux: Application of a Novel Technique for Generation of Unmarked Chromosomal Mutations for the Study of Efflux Systems Herbert P. Schweizer Antimicrob. Agents Chemother. February 1998 42: 394-398; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

-Lactamase Inhibitors Are Substrates for the Multidrug Efflux Pumps of Pseudomonas aeruginosa Xian-Zhi Li, Li Zhang, Ramakrishnan Srikumar, and Keith Poole Antimicrob. Agents Chemother. February 1998 42: 399-403; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Alterations in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV Associated with Quinolone Resistance in Enterococcus faecalis Emiko Kanematsu, Takashi Deguchi, Mitsuru Yasuda, Takeshi Kawamura, Yoshinori Nishino, and Yukimichi Kawada Antimicrob. Agents Chemother. February 1998 42: 433-435; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nucleotide and Amino Acid Sequences of the Metallo--Lactamase, ImiS, from Aeromonas veronii bv. sobria T. R. Walsh, W. A. Neville, M. H. Haran, D. Tolson, D. J. Payne, J. H. Bateson, A. P. Macgowan, and P. M. Bennett Antimicrob. Agents Chemother. February 1998 42: 436-439; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of FOX-3, an AmpC-Type Plasmid-Mediated -Lactamase from an Italian Isolate of Klebsiella oxytoca Anna Marchese, Guillaume Arlet, Gian Carlo Schito, Philippe H. Lagrange, and Alain Philippon Antimicrob. Agents Chemother. February 1998 42: 464-467; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

QacA Multidrug Efflux Pump from Staphylococcus aureus: Comparative Analysis of Resistance to Diamidines, Biguanidines, and Guanylhydrazones Bernadette A. Mitchell, Melissa H. Brown, and Ronald A. Skurray Antimicrob. Agents Chemother. February 1998 42: 475-477; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

The Novel Immunosuppressive Agent Mycophenolate Mofetil Markedly Potentiates the Antiherpesvirus Activities of Acyclovir, Ganciclovir, and Penciclovir In Vitro and In Vivo Johan Neyts, Graciela Andrei, and Erik De Clercq Antimicrob. Agents Chemother. February 1998 42: 216-222; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Fluconazole on Indinavir Pharmacokinetics in Human Immunodeficiency Virus-Infected Patients S. De Wit, M. Debier, M. De Smet, J. McCrea, J. Stone, A. Carides, C. Matthews, P. Deutsch, and N. Clumeck Antimicrob. Agents Chemother. February 1998 42: 223-227; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs Kurt Hertogs, Marie-Pierre de Béthune, Veronica Miller, Tania Ivens, Patricia Schel, Anja Van Cauwenberge, Christel Van den Eynde, Veerle van Gerwen, Hilde Azijn, Margriet van Houtte, Frank Peeters, Schlomo Staszewski, Marcus Conant, Stuart Bloor, Sharon Kemp, Brendan Larder, and Rudi Pauwels Antimicrob. Agents Chemother. February 1998 42: 269-276; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Absolute Bioavailability of Oral Foscarnet in Human Immunodeficiency Virus-Seropositive Patients Faruq H. Noormohamed, Michael S. Youle, Christopher J. Higgs, Sarah Martin-Munley, Brian G. Gazzard, and Ariel F. Lant Antimicrob. Agents Chemother. February 1998 42: 293-297; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single-Dose Pharmacokinetics of Indinavir and the Effect of Food Kuang C. Yeh, Paul J. Deutsch, Heidi Haddix, Michael Hesney, Vicki Hoagland, William D. Ju, Steven J. Justice, Barbara Osborne, Andrew T. Sterrett, Julie A. Stone, Eric Woolf, and Scott Waldman Antimicrob. Agents Chemother. February 1998 42: 332-338; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitory Effect of 2'-Fluoro-5-Methyl--L-Arabinofuranosyl-Uracil on Duck Hepatitis B Virus Replication Stéphanie Aguesse-Germon, Shwu-Huey Liu, Michèle Chevallier, Christian Pichoud, Catherine Jamard, Christelle Borel, Chung K. Chu, Christian Trépo, Yung-Chi Cheng, and Fabien Zoulim Antimicrob. Agents Chemother. February 1998 42: 369-376; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

TXU (Anti-CD7)-Pokeweed Antiviral Protein as a Potent Inhibitor of Human Immunodeficiency Virus Fatih M. Uckun, Lisa M. Chelstrom, Lisa Tuel-Ahlgren, Ilker Dibirdik, James D. Irvin, Mridula-Chandan Langlie, and Dorothea E. Myers Antimicrob. Agents Chemother. February 1998 42: 383-388; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Zalcitabine Population Pharmacokinetics: Application of Radioimmunoassay John M. Adams, Mark J. Shelton, Ross G. Hewitt, Mary DeRemer, Robin DiFrancesco, Thaddeus H. Grasela, and Gene D. Morse Antimicrob. Agents Chemother. February 1998 42: 409-413; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Cys607Tyr Change in the UL97 Phosphotransferase Confers Ganciclovir Resistance to Two Human Cytomegalovirus Strains Recovered from Two Immunocompromised Patients Fausto Baldanti, Mark R. Underwood, Christine L. Talarico, Lavinia Simoncini, Antonella Sarasini, Karen K. Biron, and Giuseppe Gerna Antimicrob. Agents Chemother. February 1998 42: 444-446; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Mutation at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Interacts with Mutations at Positions 74 and 75 via the Template Primer Paul L. Boyer, Hong-Qiang Gao, and Stephen H. Hughes Antimicrob. Agents Chemother. February 1998 42: 447-452; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Estimate of the Frequency of Human Immunodeficiency Virus Type 1 Protease Inhibitor Resistance within Unselected Virus Populations In Vitro Simon P. Tucker, Thomas R. Stiebel, Jr., Karen E. Potts, Mary L. Smidt, and Martin L. Bryant Antimicrob. Agents Chemother. February 1998 42: 478-480; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

Pharmacodynamics of Ampicillin-Sulbactam in an In Vitro Infection Model against Escherichia coli Strains with Various Levels of Resistance Kenneth C. Lamp and Mary K. Vickers Antimicrob. Agents Chemother. February 1998 42: 231-235; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Toxicological Profile and Pharmacokinetics of a Unilamellar Liposomal Vesicle Formulation of Amphotericin B in Rats Garry W. Boswell, Ihor Bekersky, Donald Buell, Richard Hiles, and Thomas J. Walsh Antimicrob. Agents Chemother. February 1998 42: 263-268; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Release of Lipoteichoic and Teichoic Acids from Streptococcus pneumoniae as a Result of Exposure to -Lactam Antibiotics, Rifamycins, Trovafloxacin, and Quinupristin-Dalfopristin K. Stuertz, H. Schmidt, H. Eiffert, P. Schwartz, M. Mäder, and R. Nau Antimicrob. Agents Chemother. February 1998 42: 277-281; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of Renal Failure on Ciprofloxacin Pharmacokinetics in Rats B. Nouaille-Degorce, C. Veau, S. Dautrey, M. Tod, D. Laouari, C. Carbon, and R. Farinotti Antimicrob. Agents Chemother. February 1998 42: 289-292; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of the Safety and Pharmacokinetic Profile of a New, Pasteurized, Human Tetanus Immunoglobulin Administered as Sham, Postexposure Prophylaxis of Tetanus Rémi Forrat, Rafaele Dumas, Michael Seiberling, Michael Merz, Charles Lutsch, and Jean Lang Antimicrob. Agents Chemother. February 1998 42: 298-305; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Stereoselective Disposition of Sulbenicillin in Humans Tomoo Itoh, Naoko Watanabe, Mariko Ishida, Yasuyuki Tsuda, Shinichi Koyano, Tomoko Tsunoi, Hideyo Shimada, and Hideo Yamada Antimicrob. Agents Chemother. February 1998 42: 325-331; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mathematical Modeling of the Interrelationship of CD4 Lymphocyte Count and Viral Load Changes Induced by the Protease Inhibitor Indinavir George L. Drusano and Daniel S. Stein Antimicrob. Agents Chemother. February 1998 42: 358-361; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Repeated-Dose Pharmacokinetics of an Oral Solution of Itraconazole in Infants and Children Louis de Repentigny, Johanne Ratelle, Jean-Marie Leclerc, Guy Cornu, Étienne M. Sokal, Philippe Jacqmin, and Karel de Beule Antimicrob. Agents Chemother. February 1998 42: 404-408; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic and Sub-MIC Effects of Azithromycin and Isepamicin against Staphylococcus aureus and Escherichia coli F. Fuentes, J. Izquierdo, M. M. Martín, M. L. Gomez-Lus, and J. Prieto Antimicrob. Agents Chemother. February 1998 42: 414-418; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Concentrations of Pefloxacin in Plasma and Tissue after Administration as Surgical Prophylaxis Bernadette Jacoberger, Genevieve Ubeaud, Guy Freys, Thierry Pottecher, Louis Jung, and Jean Claude Koffel Antimicrob. Agents Chemother. February 1998 42: 425-427; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Inflammatory Fluid Penetration of Clinafloxacin R. Wise, S. Jones, I. Das, and J. M. Andrews Antimicrob. Agents Chemother. February 1998 42: 428-430; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Aluminum Hydroxide and Famotidine on Bioavailability of Tosufloxacin in Healthy Volunteers Rumiko Minami, Chizuko Nakamura, Nobuo Inotsume, and Masahiro Nakano Antimicrob. Agents Chemother. February 1998 42: 453-455; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Probenecid and Cimetidine on Renal Disposition of Ofloxacin in Rats Edward F. Foote and Charles E. Halstenson Antimicrob. Agents Chemother. February 1998 42: 456-458; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Cholera Toxin on Intestinal Elimination of Ciprofloxacin in Rabbits Albert Musafija, Asher Barzilai, Jacob Ramon, and Ethan Rubinstein Antimicrob. Agents Chemother. February 1998 42: 473-474; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Experimental Therapeutics:

---

Efficacy of Trovafloxacin against Experimental Staphylococcus aureus Endocarditis Glenn W. Kaatz, Susan M. Seo, Jeffrey R. Aeschlimann, Heather H. Houlihan, Reneé-Claude Mercier, and Michael J. Rybak Antimicrob. Agents Chemother. February 1998 42: 254-256; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of Possible Correlations between Antifungal Susceptibilities of Filamentous Fungi In Vitro and Antifungal Treatment Outcomes in Animal Infection Models F. C. Odds, F. Van Gerven, A. Espinel-Ingroff, M. S. Bartlett, M. A. Ghannoum, M. V. Lancaster, M. A. Pfaller, J. H. Rex, M. G. Rinaldi, and T. J. Walsh Antimicrob. Agents Chemother. February 1998 42: 282-288; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Peptide-Grafted Liposomal Delivery System Targeted to Macrophages Goutam Banerjee, Swapna Medda, and Mukul K. Basu Antimicrob. Agents Chemother. February 1998 42: 348-351; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Doxycycline Hyclate Treatment of Experimental Canine Ehrlichiosis Followed by Challenge Inoculation with Two Ehrlichia canis Strains Edward B. Breitschwerdt, Barbara C. Hegarty, and Susan I. Hancock Antimicrob. Agents Chemother. February 1998 42: 362-368; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Pharmacodynamics of Azithromycin and Erythromycin In Vitro and In Vivo Jan G. den Hollander, Jenny D. Knudsen, Johan W. Mouton, Kurt Fuursted, Niels Frimodt-Møller, Henri A. Verbrugh, and Frank Espersen Antimicrob. Agents Chemother. February 1998 42: 377-382; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rationale for and Efficacy of Prolonged-Interval Treatment Using Liposome-Encapsulated Amikacin in Experimental Mycobacterium avium Infection S. Leitzke, W. Bucke, K. Borner, R. Müller, H. Hahn, and S. Ehlers Antimicrob. Agents Chemother. February 1998 42: 459-461; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Critical Importance of In Vivo Amoxicillin and Cefotaxime Concentrations for Synergy in Treatment of Experimental Enterococcus faecalis Endocarditis Olivier Join-Lambert, Jean-Luc Mainardi, Catherine Cuvelier, Sophie Dautrey, Robert Farinotti, Bruno Fantin, and Claude Carbon Antimicrob. Agents Chemother. February 1998 42: 468-470; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

In Vitro Activity of a New Oral Triazole, BMS-207147 (ER-30346) Joan C. Fung-Tomc, Elizabeth Huczko, Beatrice Minassian, and Daniel P. Bonner Antimicrob. Agents Chemother. February 1998 42: 313-318; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility of Haemophilus influenzae in the Respiratory Tracts of Patients with Cystic Fibrosis Lieke V. M. Möller, Annette G. Regelink, Henny Grasselier, Loek van Alphen, and Jacob Dankert Antimicrob. Agents Chemother. February 1998 42: 319-324; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Green Fluorescent Protein Reporter Microplate Assay for High-Throughput Screening of Compounds against Mycobacterium tuberculosis L. A. Collins, M. N. Torrero, and S. G. Franzblau Antimicrob. Agents Chemother. February 1998 42: 344-347; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Y-688, a New 7-Substituted Fluoroquinolone, against Anaerobic Bacteria A. P. MacGowan, K. E. Bowker, M. Wootton, H. A. Holt, and D. S. Reeves Antimicrob. Agents Chemother. February 1998 42: 419-424; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Susceptibility of Enterohemorrhagic Escherichia coli O157:H7 Isolated from an Outbreak in Japan in 1996 Isami Tsuboi, Hirohisa Ida, Eiji Yoshikawa, Suehiro Hiyoshi, Emiko Yamaji, Issei Nakayama, Tomoko Nonomiya, Fritz Shigenobu, Masaki Shimizu, Koji O'Hara, Tetsuo Sawai, and Keiji Mizuoka Antimicrob. Agents Chemother. February 1998 42: 431-432; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Resistance in Shigella flexneri and Shigella sonnei in Hong Kong, 1986 to 1995 Yiu-wai Chu, Elizabeth T. S. Houang, Donald J. Lyon, Julia M. Ling, Tak-keung Ng, and Augustine F. B. Cheng Antimicrob. Agents Chemother. February 1998 42: 440-443; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide Michael H. Cynamon, Robert J. Speirs, and John T. Welch Antimicrob. Agents Chemother. February 1998 42: 462-463; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Comparative Efficacy of Voriconazole and Itraconazole against Fluconazole-Susceptible and -Resistant Cryptococcus neoformans Isolates M. Hong Nguyen and Christine Y. Yu Antimicrob. Agents Chemother. February 1998 42: 471-472; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Chemistry; Biosynthesis:

---

Synthesis and Evaluation of Dinitroanilines for Treatment of Cryptosporidiosis John W. Benbow, Erin L. Bernberg, Anna Korda, and Jan R. Mead Antimicrob. Agents Chemother. February 1998 42: 339-343; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

Cellular Accumulation, Localization, and Activity of a Synthetic Cyclopeptamine in Fungi John O. Capobianco, Dorothy Zakula, David J. Frost, Robert C. Goldman, Leping Li, Larry L. Klein, and Paul A. Lartey Antimicrob. Agents Chemother. February 1998 42: 389-393; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Letters:

---

Bronchopulmonary Pharmacokinetics of Clarithromycin and Azithromycin Angela D. M. Kashuba, Guy W. Amsden;, K. B. Patel, D. Xuan, P. R. Tessier, R. Quintiliani, and C. H. Nightingale Antimicrob. Agents Chemother. February 1998 42: 481-482; [Full Text] [PDF] [Reprints and Permissions]

Nomenclature of Genes Encoding Aminoglycoside-Modifying Enzymes Raymond Vanhoof, Eleonora Hannecart-Pokorni, and Jean Content Antimicrob. Agents Chemother. February 1998 42: 483 [Full Text] [PDF] [Reprints and Permissions]

---

Errata:

---

Widespread Detection of PER-1-Type Extended-Spectrum -Lactamases among Nosocomial Acinetobacter and Pseudomonas aeruginosa Isolates in Turkey: a Nationwide Multicenter Study Haluk Vahaboglu, Recep Öztürk, Gökhan Aygün, Akgün Yaman, Arif Kaygusuz, Hakan Leblebicioglu, Kemalettin Aydin, and Metin Otkun Antimicrob. Agents Chemother. February 1998 42: 484 [Full Text] [PDF] [Reprints and Permissions]

---

Author's Correction:

---

Characterization of the 6'-N-Aminoglycoside Acetyltransferase Gene aac(6')-Il Associated with a sulI-Type Integron Eleonora Hannecart-Pokorni, Freddy Depuydt, Lucas De Wit, Eddie Van Bossuyt, Jean Content, and Raymond Vanhoof Antimicrob. Agents Chemother. February 1998 42: 485 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.