Contents: March 1998, Volume 42, Issue 3        Antiviral Agents        Susceptibility        Mechanisms of Resistance        Mechanisms of Action        Pharmacology        Experimental Therapeutics        Biologic Response Modifiers        Clinical Therapeutics        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Antiviral Agents:

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Inhibition of Acute-, Latent-, and Chronic-Phase Human Immunodeficiency Virus Type 1 (HIV-1) Replication by a Bistriazoloacridone Analog That Selectively Inhibits HIV-1 Transcription Jim A. Turpin, Robert W. Buckheit, Jr., David Derse, Melinda Hollingshead, Karen Williamson, Carla Palamone, M. Clayton Osterling, Shawn A. Hill, Lisa Graham, Catherine A. Schaeffer, Ming Bu, Mingjun Huang, Wieslaw M. Cholody, Christopher J. Michejda, and William G. Rice Antimicrob. Agents Chemother. March 1998 42: 487-494; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9-R-(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA Brian L. Robbins, Ranga V. Srinivas, Choung Kim, Norbert Bischofberger, and Arnold Fridland Antimicrob. Agents Chemother. March 1998 42: 612-617; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity M. Witvrouw, M. E. Arranz, C. Pannecouque, R. Declercq, H. Jonckheere, J.-C. Schmit, A.-M. Vandamme, J. A. Diaz, S. T. Ingate, J. Desmyter, R. Esnouf, L. Van Meervelt, S. Vega, J. Balzarini, and E. De Clercq Antimicrob. Agents Chemother. March 1998 42: 618-623; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection Dirk B. Mendel, Chun Y. Tai, Paul A. Escarpe, Weixing Li, Robert W. Sidwell, John H. Huffman, Clive Sweet, Kenneth J. Jakeman, James Merson, Steven A. Lacy, Willard Lew, Matthew A. Williams, Lijun Zhang, Ming S. Chen, Norbert Bischofberger, and Choung U. Kim Antimicrob. Agents Chemother. March 1998 42: 640-646; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Weixing Li, Paul A. Escarpe, Eugene J. Eisenberg, Kenneth C. Cundy, Clive Sweet, Kenneth J. Jakeman, James Merson, Willard Lew, Matt Williams, Lijun Zhang, Choung U. Kim, Norbert Bischofberger, Ming S. Chen, and Dirk B. Mendel Antimicrob. Agents Chemother. March 1998 42: 647-653; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro Activities of Cefminox against Anaerobic Bacteria Compared with Those of Nine Other Compounds Dianne B. Hoellman, Sheila K. Spangler, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. March 1998 42: 495-501; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine O. Domarle, G. Blampain, H. Agnaniet, T. Nzadiyabi, J. Lebibi, J. Brocard, L. Maciejewski, C. Biot, A. J. Georges, and P. Millet Antimicrob. Agents Chemother. March 1998 42: 540-544; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of Antimicrobial-Resistant Pathogens in Middle Ear Fluid: Multinational Study of 917 Children with Acute Otitis Media Michael R. Jacobs, Ron Dagan, Peter C. Appelbaum, and Daniel J. Burch Antimicrob. Agents Chemother. March 1998 42: 589-595; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibilities of Penicillin- and Erythromycin-Susceptible and -Resistant Pneumococci to HMR 3647 (RU 66647), a New Ketolide, Compared with Susceptibilities to 17 Other Agents G. A. Pankuch, M. A. Visalli, M. R. Jacobs, and P. C. Appelbaum Antimicrob. Agents Chemother. March 1998 42: 624-630; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Quinupristin-Dalfopristin and the Streptogramin RPR 106972 against Mycoplasma pneumoniae Koichi Izumikawa, Yoichi Hirakata, Toshiyuki Yamaguchi, Ryoji Yoshida, Hironori Tanaka, Hiromu Takemura, Shigefumi Maesaki, Kazunori Tomono, Mitsuo Kaku, Kin-Ichi Izumikawa, Shimeru Kamihira, and Shigeru Kohno Antimicrob. Agents Chemother. March 1998 42: 698-699; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activity of Novel Furanonaphthoquinone Analogs Kumiko Nagata, Kei-Ichi Hirai, Junko Koyama, Yasunao Wada, and Toshihide Tamura Antimicrob. Agents Chemother. March 1998 42: 700-702; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of BAY 12-8039, a New Fluoroquinolone, against Mycoplasmas C. M. Bébéar, H. Renaudin, A. Boudjadja, and C. Bébéar Antimicrob. Agents Chemother. March 1998 42: 703-704; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Antibiotic Micrococcin Is a Potent Inhibitor of Growth and Protein Synthesis in the Malaria Parasite M. John Rogers, Eric Cundliffe, and Thomas F. McCutchan Antimicrob. Agents Chemother. March 1998 42: 715-716; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Activities and Postantibiotic Effects of the Oxazolidinone Compounds Eperezolid (PNU-100592) and Linezolid (PNU-100766) versus Vancomycin against Staphylococcus aureus, Coagulase-Negative Staphylococci, Enterococcus faecalis, and Enterococcus faecium Michael J. Rybak, Diane M. Cappelletty, Tabitha Moldovan, Jeffrey R. Aeschlimann, and Glenn W. Kaatz Antimicrob. Agents Chemother. March 1998 42: 721-724; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Diversity of VanA Glycopeptide Resistance Elements in Enterococci from Humans and Nonhuman Sources Neil Woodford, Antoinette-Mary A. Adebiyi, Marie-France I. Palepou, and Barry D. Cookson Antimicrob. Agents Chemother. March 1998 42: 502-508; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ceftazidime-Resistant Enterobacteriaceae Isolates from Three Polish Hospitals: Identification of Three Novel TEM- and SHV-5-Type Extended-Spectrum -Lactamases Marek Gniadkowski, Ines Schneider, Renate Jungwirth, Waleria Hryniewicz, and Adolf Bauernfeind Antimicrob. Agents Chemother. March 1998 42: 514-520; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Gene Encoding the Low-Affinity Penicillin-Binding Protein 3r in Enterococcus hirae S185R Is Borne on a Plasmid Carrying Other Antibiotic Resistance Determinants Dominique Raze, Olivier Dardenne, Séverine Hallut, Manuel Martinez-Bueno, Jacques Coyette, and Jean-Marie Ghuysen Antimicrob. Agents Chemother. March 1998 42: 534-539; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Introduction of the mec Element (Methicillin Resistance) into Staphylococcus aureus Alters In Vitro Functional Activities of Fibrinogen and Fibronectin Adhesins Pierre E. Vaudaux, Vincenza Monzillo, Patrice Francois, Daniel P. Lew, Tim J. Foster, and Brigitte Berger-Bächi Antimicrob. Agents Chemother. March 1998 42: 564-570; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reduced Clinical Efficacy of Pazufloxacin against Gonorrhea Due to High Prevalence of Quinolone-Resistant Isolates with the GyrA Mutation Masatoshi Tanaka, Tetsuro Matsumoto, Misao Sakumoto, Koichi Takahashi, Takeshi Saika, Intetsu Kabayashi, Joichi Kumazawa, and The Pazufloxacin Std Group Antimicrob. Agents Chemother. March 1998 42: 579-582; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Mediated Resistance to Expanded-Spectrum Cephalosporins among Enterobacter aerogenes Strains Johann D. D. Pitout, Kenneth S. Thomson, Nancy D. Hanson, Anton F. Ehrhardt, Philip Coudron, and Christine C. Sanders Antimicrob. Agents Chemother. March 1998 42: 596-600; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Resistance in Enterococci Isolated from Turkey Flocks Fed Virginiamycin L. A. Welton, L. A. Thal, M. B. Perri, S. Donabedian, J. McMahon, J. W. Chow, and M. J. Zervos Antimicrob. Agents Chemother. March 1998 42: 705-708; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of Diversity of Mutations in the mecI Gene and mecA Promoter/Operator Region of Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis Nobumichi Kobayashi, Koki Taniguchi, and Shozo Urasawa Antimicrob. Agents Chemother. March 1998 42: 717-720; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Inhibition of RNA Synthesis as a Therapeutic Strategy against Aspergillus and Fusarium: Demonstration of In Vitro Synergy between Rifabutin and Amphotericin B Cornelius J. Clancy, Yue C. Yu, Alfred Lewin, and M. Hong Nguyen Antimicrob. Agents Chemother. March 1998 42: 509-513; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Bicyclomycin on RNA- and ATP-Binding Activities of Transcription Termination Factor Rho Lucia Carrano, Cecilia Bucci, Roberto De Pascalis, Alfredo Lavitola, Filomena Manna, Emiliana Corti, Carmelo Bruno Bruni, and Pietro Alifano Antimicrob. Agents Chemother. March 1998 42: 571-578; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship between Antimalarial Drug Activity, Accumulation, and Inhibition of Heme Polymerization in Plasmodium falciparum In Vitro Shaun R. Hawley, Patrick G. Bray, Mathirut Mungthin, Jill D. Atkinson, Paul M. O'Neill, and Stephen A. Ward Antimicrob. Agents Chemother. March 1998 42: 682-686; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Superoxide in Catalase-Peroxidase-Mediated Isoniazid Action against Mycobacteria Jian-Ying Wang, Richard M. Burger, and Karl Drlica Antimicrob. Agents Chemother. March 1998 42: 709-711; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacodynamic Evaluation of Factors Associated with the Development of Bacterial Resistance in Acutely Ill Patients during Therapy Jennifer K. Thomas, Alan Forrest, Sujata M. Bhavnani, Judith M. Hyatt, Angela Cheng, Charles H. Ballow, and Jerome J. Schentag Antimicrob. Agents Chemother. March 1998 42: 521-527; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tolerance and Pharmacokinetic Interactions of Rifabutin and Clarithromycin in Human Immunodeficiency Virus-Infected Volunteers Richard Hafner, James Bethel, Maureen Power, Bernard Landry, Mary Banach, Larry Mole, Harold C. Standiford, Stephen Follansbee, Princy Kumar, Ralph Raasch, David Cohn, David Mushatt, and George Drusano Antimicrob. Agents Chemother. March 1998 42: 631-639; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inter- and Intraquinolone Predictors of Antimicrobial Effect in an In Vitro Dynamic Model: New Insight into a Widely Used Concept Alexander A. Firsov, Alexander A. Shevchenko, Sergey N. Vostrov, and Stephen H. Zinner Antimicrob. Agents Chemother. March 1998 42: 659-665; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Bioavailability of the Anti-Human Immunodeficiency Virus Nucleotide Analog 9-[(R)2-(Phosphonomethoxy)Propyl]Adenine (PMPA) in Dogs Kenneth C. Cundy, Cathy Sueoka, Geoffrey R. Lynch, Linda Griffin, William A. Lee, and Jeng-Pyng Shaw Antimicrob. Agents Chemother. March 1998 42: 687-690; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Neurotoxicodynamics of the Interaction between Ciprofloxacin and Foscarnet in Mice Hirotami Matsuo, Miwako Ryu, Aya Nagata, Takahiro Uchida, Jun-Ichi Kawakami, Koujirou Yamamoto, Tatsuji Iga, and Yasufumi Sawada Antimicrob. Agents Chemother. March 1998 42: 691-694; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Terbinafine on Theophylline Pharmacokinetics in Healthy Volunteers Eric F. Trépanier, Anne N. Nafziger, and Guy W. Amsden Antimicrob. Agents Chemother. March 1998 42: 695-697; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Amphotericin B Colloidal Dispersion Combined with Flucytosine with or without Fluconazole for Treatment of Murine Cryptococcal Meningitis DeAnn M. Diamond, Madeline Bauer, Barbra E. Daniel, Mary Ann E. Leal, Debra Johnson, Byron K. Williams, Ann M. Thomas, James C. Ding, Laura Najvar, J. Richard Graybill, and Robert A. Larsen Antimicrob. Agents Chemother. March 1998 42: 528-533; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prophylactic Anti-Infective Activity of Poly-[1-6]--D-Glucopyranosyl-[1-3]--D-Glucopyranose Glucan in a Guinea Pig Model of Staphylococcal Wound Infection Douglas S. Kernodle, Hiriam Gates, and Allen B. Kaiser Antimicrob. Agents Chemother. March 1998 42: 545-549; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antibacterial Activities of CS-834, a New Oral Carbapenem Keizo Yamaguchi, Haruki Domon, Shuichi Miyazaki, Kazuhiro Tateda, Akira Ohno, Kazuhiro Ishii, Tetsuya Matsumoto, and Nobuhiko Furuya Antimicrob. Agents Chemother. March 1998 42: 555-563; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oxfendazole Treatment for Cystic Hydatid Disease in Naturally Infected Animals Ronald E. Blanton, Timothy M. Wachira, Eberhard E. Zeyhle, Ernest M. Njoroge, Japheth K. Magambo, and Peter M. Schantz Antimicrob. Agents Chemother. March 1998 42: 601-605; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Short- and Long-Term Efficacy of Hexadecylphosphocholine against Established Leishmania infantum Infection in BALB/c Mice Yves Le Fichoux, Déborah Rousseau, Bernard Ferrua, Sandrine Ruette, Alain Lelièvre, Dominique Grousson, and Joanna Kubar Antimicrob. Agents Chemother. March 1998 42: 654-658; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Pneumocystis Activities of Aromatic Diamidoxime Prodrugs James Edwin Hall, John E. Kerrigan, Kishore Ramachandran, Brendan C. Bender, Jason P. Stanko, Susan K. Jones, Donald A. Patrick, and Richard R. Tidwell Antimicrob. Agents Chemother. March 1998 42: 666-674; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibiotic Treatment of Experimental Pneumonic Plague in Mice William R. Byrne, Susan L. Welkos, M. Louise Pitt, Kelly J. Davis, Ralf P. Brueckner, John W. Ezzell, Gene O. Nelson, Joseph R. Vaccaro, Luann C. Battersby, and Arthur M. Friedlander Antimicrob. Agents Chemother. March 1998 42: 675-681; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Isoniazid Alone and in Combination with Other Drugs against Mycobacterium avium Infection in Beige Mice Lanfranco Fattorini, Yan Xiao, Maurizio Mattei, Yongjun Li, Elisabetta Iona, Maria Luisa Ricci, Ove Fredrik Thoresen, Roberta Creti, and Graziella Orefici Antimicrob. Agents Chemother. March 1998 42: 712-714; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Rifampin Increases Cytokine-Induced Expression of the CD1b Molecule in Human Peripheral Blood Monocytes L. Tentori, G. Graziani, S. A. Porcelli, M. Sugita, M. B. Brenner, R. Madaio, E. Bonmassar, A. Giuliani, and A. Aquino Antimicrob. Agents Chemother. March 1998 42: 550-554; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Covalent Polymyxin B Conjugate with Human Immunoglobulin G as an Antiendotoxin Reagent Joseph J. Drabick, Apurba K. Bhattacharjee, David L. Hoover, George E. Siber, Vivian E. Morales, Lynnette D. Young, Scott L. Brown, and Alan S. Cross Antimicrob. Agents Chemother. March 1998 42: 583-588; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Treatment of Invasive Fungal Infections in Renally Impaired Patients with Amphotericin B Colloidal Dispersion Elias J. Anaissie, Gloria N. Mattiuzzi, Carole B. Miller, Gary A. Noskin, Marc J. Gurwith, Richard D. Mamelok, and Larry A. Pietrelli Antimicrob. Agents Chemother. March 1998 42: 606-611; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Morphological Effects of Miconazole on Helicobacter pylori G. von Recklinghausen, E. N. Schmid, A. Vollmer, and R. Ansorg Antimicrob. Agents Chemother. March 1998 42: 725-726; [Full Text] [PDF] [Reprints and Permissions]

Selection of Fluoroquinolone-Resistant Methicillin-Resistant Staphylococcus aureus with Ciprofloxacin and Trovafloxacin Martin E. Evans and William B. Titlow Antimicrob. Agents Chemother. March 1998 42: 727 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.