Contents: April 1998, Volume 42, Issue 4        Clinical Therapeutics        Susceptibility        Mechanisms of Action        Pharmacology        Mechanisms of Resistance        Experimental Therapeutics        Antiviral Agents        Analytical Procedures        Biologic Response Modifiers        Recent Approvals        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Clinical Therapeutics:

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Cefepime versus Ceftriaxone for Empiric Treatment of Hospitalized Patients with Community-Acquired Pneumonia M. Zervos, M. Nelson, and the Cefepime Study Group Antimicrob. Agents Chemother. April 1998 42: 729-733; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Thirteen-Year Evolution of Azole Resistance in Yeast Isolates and Prevalence of Resistant Strains Carried by Cancer Patients at a Large Medical Center Cynthia R. Boschman, Ulana R. Bodnar, Michelle A. Tornatore, Arlene A. Obias, Gary A. Noskin, Kristin Englund, Michael A. Postelnick, Terra Suriano, and Lance R. Peterson Antimicrob. Agents Chemother. April 1998 42: 734-738; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Amphotericin B in Lipid Emulsion: Stability, Compatibility, and In Vitro Antifungal Activity Scott Walker, Sandra A. N. Tailor, Mark Lee, Lisa Louie, Marie Louie, and Andrew E. Simor Antimicrob. Agents Chemother. April 1998 42: 762-766; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Evaluation of Drug Susceptibilities of Babesia divergens Isolates Philippe Brasseur, Sophie Lecoublet, Nathalie Kapel, Loic Favennec, and Jean J. Ballet Antimicrob. Agents Chemother. April 1998 42: 818-820; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cyclosporin Analogs Inhibit In Vitro Growth of Cryptosporidium parvum Margaret E. Perkins, Teresa W. Wu, and Sylvie M. Le Blancq Antimicrob. Agents Chemother. April 1998 42: 843-848; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities and Time-Kill Studies of Selected Penicillins, -Lactamase Inhibitor Combinations, and Glycopeptides against Enterococcus faecalis Dianne B. Hoellman, Melissa A. Visalli, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. April 1998 42: 857-861; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synthesis and Antibacterial Evaluation of Novel Water-Soluble Organic Peroxides Wenqiu Liu, Xuejun Liu, David Knaebel, Linda Luck, and Yuzhou Li Antimicrob. Agents Chemother. April 1998 42: 911-915; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Slime Produced by Clinical Isolates of Coagulase-Negative Staphylococci on Activities of Various Antimicrobial Agents Maria Souli and Helen Giamarellou Antimicrob. Agents Chemother. April 1998 42: 939-941; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Killing Activities of Meropenem, Imipenem, Ceftriaxone, and Ceftriaxone plus Vancomycin at Clinically Achievable Cerebrospinal Fluid Concentrations against Penicillin-Resistant Streptococcus pneumoniae Isolates from Children with Meningitis Frederic Fitoussi, Catherine Doit, Karim Benali, Stephane Bonacorsi, Pierre Geslin, and Edouard Bingen Antimicrob. Agents Chemother. April 1998 42: 942-944; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antipneumococcal Activities of a Ketolide (HMR 3647), a Streptogramin (Quinupristin-Dalfopristin), a Macrolide (Erythromycin), and a Lincosamide (Clindamycin) A. L. Barry, P. C. Fuchs, and S. D. Brown Antimicrob. Agents Chemother. April 1998 42: 945-946; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of a New 8-Methoxyquinolone, BAY 12-8039, against Chlamydia pneumoniae Patricia M. Roblin and Margaret R. Hammerschlag Antimicrob. Agents Chemother. April 1998 42: 951-952; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Determination of Activities of Levofloxacin, Alone and Combined with Gentamicin, Ceftazidime, Cefpirome, and Meropenem, against 124 Strains of Pseudomonas aeruginosa by Checkerboard and Time-Kill Methodology Melissa A. Visalli, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. April 1998 42: 953-955; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Bordetella pertussis and Bordetella parapertussis to Two Ketolides (HMR 3004 and HMR 3647), Four Macrolides (Azithromycin, Clarithromycin, Erythromycin A, and Roxithromycin), and Two Ansamycins (Rifampin and Rifapentine) Jörg E. Hoppe and André Bryskier Antimicrob. Agents Chemother. April 1998 42: 965-966; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Alginate Lyase Promotes Diffusion of Aminoglycosides through the Extracellular Polysaccharide of Mucoid Pseudomonas aeruginosa Richard A. Hatch and Neal L. Schiller Antimicrob. Agents Chemother. April 1998 42: 974-977; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibilities of Clinical and Laboratory Isolates of Blastomyces dermatitidis to Ketoconazole, Itraconazole, and Fluconazole Stanley W. Chapman, P. David Rogers, Michael G. Rinaldi, and Donna C. Sullivan Antimicrob. Agents Chemother. April 1998 42: 978-980; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Levofloxacin against a Selected Group of Anaerobic Bacteria Isolated from Skin and Soft Tissue Infections Hannah M. Wexler, Eric Molitoris, Denise Molitoris, and Sydney M. Finegold Antimicrob. Agents Chemother. April 1998 42: 984-986; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Antibiotic-Induced Lipopolysaccharide (LPS) Release from Salmonella typhi: Delay between Killing by Ceftazidime and Imipenem and Release of LPS Petra van Langevelde, Kitty M. C. Kwappenberg, Paul H. P. Groeneveld, Herman Mattie, and Jaap T. van Dissel Antimicrob. Agents Chemother. April 1998 42: 739-743; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiproliferative and Apoptotic Activities of Ketonucleosides and Keto-C-Glycosides against Non-Small-Cell Lung Cancer Cells with Intrinsic Drug Resistance Jesse Paterson, Clara Uriel, Marie-Jose Egron, Jean Herscovici, Kostas Antonakis, and Moulay A. Alaoui-Jamali Antimicrob. Agents Chemother. April 1998 42: 779-784; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Accumulation of Norfloxacin by Mycobacterium aurum and Mycobacterium smegmatis Kerstin J. Williams, Gavin A. C. Chung, and Laura J. V. Piddock Antimicrob. Agents Chemother. April 1998 42: 795-800; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Increased Overall Antibiotic Susceptibility in Staphylococcus aureus femAB Null Mutants Baodong Ling and Brigitte Berger-Bächi Antimicrob. Agents Chemother. April 1998 42: 936-938; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Use of Pharmacodynamic Parameters To Predict Efficacy of Combination Therapy by Using Fractional Inhibitory Concentration Kinetics Jan G. den Hollander, Johan W. Mouton, and Henri A. Verbrugh Antimicrob. Agents Chemother. April 1998 42: 744-748; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Duration and Clinical Relevance of Postantibiotic Effect in Relation to the Dosing Interval Jan G. den Hollander, Kurt Fuursted, Henri A. Verbrugh, and Johan W. Mouton Antimicrob. Agents Chemother. April 1998 42: 749-754; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetic Study of Amikacin Administered Once or Twice Daily to Febrile, Severely Neutropenic Adults Michel Tod, Olivier Lortholary, Delphine Seytre, Rémi Semaoun, Bernard Uzzan, Loïc Guillevin, Philippe Casassus, and Olivier Petitjean Antimicrob. Agents Chemother. April 1998 42: 849-856; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Double-Blind Evaluation of the Safety and Pharmacokinetics of Multiple Oral Once-Daily 750-Milligram and 1-Gram Doses of Levofloxacin in Healthy Volunteers Shu-Chean Chien, Frank A. Wong, Cynthia L. Fowler, Susan V. Callery-D'Amico, R. Rex Williams, Ramchandra Nayak, and Andrew T. Chow Antimicrob. Agents Chemother. April 1998 42: 885-888; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Two Multiple-Dosing Regimens of D0870 in Human Immunodeficiency Virus-Positive Patients: a Phase I Study S. De Wit, E. O'Doherty, J. Edwards, R. Yates, R. P. Smith, and A. N. Clumeck Antimicrob. Agents Chemother. April 1998 42: 903-906; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Grapefruit Juice on Clarithromycin Pharmacokinetics Kit L. Cheng, Anne N. Nafziger, Charles A. Peloquin, and Guy W. Amsden Antimicrob. Agents Chemother. April 1998 42: 927-929; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fluconazole Pharmacokinetics in Burn Patients Bradley A. Boucher, Stephen R. King, Heidi L. Wandschneider, William L. Hickerson, Scott D. Hanes, Vanessa L. Herring, Todd W. Canada, and Mary M. Hess Antimicrob. Agents Chemother. April 1998 42: 930-933; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Role of ABC Transporters in Aureobasidin A Resistance Atsuko Ogawa, Takashi Hashida-Okado, Masahiro Endo, Hirofumi Yoshioka, Takashi Tsuruo, Kazutoh Takesako, and Ikunoshin Kato Antimicrob. Agents Chemother. April 1998 42: 755-761; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antifungal Activity of Amphotericin B Lipid Complex: Are Phospholipases Important? Christine E. Swenson, Walter R. Perkins, Patricia Roberts, Imran Ahmad, Rachel Stevens, David A. Stevens, and Andrew S. Janoff Antimicrob. Agents Chemother. April 1998 42: 767-771; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cefotaxime-Resistant Enterobacteriaceae Isolates from a Hospital in Warsaw, Poland: Identification of a New CTX-M-3 Cefotaxime-Hydrolyzing -Lactamase That Is Closely Related to the CTX-M-1/MEN-1 Enzyme Marek Gniadkowski, Ines Schneider, Renate Jungwirth, Barbara Mikiewicz, and Adolf Bauernfeind Antimicrob. Agents Chemother. April 1998 42: 827-832; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Discriminatory Detection of Inhibitor-Resistant -Lactamases in Escherichia coli by Single-Strand Conformation Polymorphism-PCR Valérie Speldooren, Beate Heym, Roger Labia, and Marie-Hélène Nicolas-Chanoine Antimicrob. Agents Chemother. April 1998 42: 879-884; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of Bacterial Biofilm Formation on In Vitro and In Vivo Activities of Antibiotics Silvia Schwank, Zarko Rajacic, Werner Zimmerli, and Jürg Blaser Antimicrob. Agents Chemother. April 1998 42: 895-898; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Overexpression, Purification, and Characterization of the Cloned Metallo--Lactamase L1 from Stenotrophomonas maltophilia Michael W. Crowder, Timothy R. Walsh, Linda Banovic, Margaret Pettit, and James Spencer Antimicrob. Agents Chemother. April 1998 42: 921-926; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ribosomes from an Oxazolidinone-Resistant Mutant Confer Resistance to Eperezolid in a Staphylococcus aureus Cell-Free Transcription-Translation Assay Robert W. Murray, Ronda D. Schaadt, Gary E. Zurenko, and Keith R. Marotti Antimicrob. Agents Chemother. April 1998 42: 947-950; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Killing of Staphylococcus aureus by C-8-Methoxy Fluoroquinolones Xilin Zhao, Jian-Ying Wang, Chen Xu, Yuzhi Dong, Jianfeng Zhou, John Domagala, and Karl Drlica Antimicrob. Agents Chemother. April 1998 42: 956-958; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in aarE, the ubiA Homolog of Providencia stuartii, Result in High-Level Aminoglycoside Resistance and Reduced Expression of the Chromosomal Aminoglycoside 2'-N-Acetyltransferase Michael R. Paradise, Gregory Cook, Robert K. Poole, and Philip N. Rather Antimicrob. Agents Chemother. April 1998 42: 959-962; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Transferable, Plasmid-Mediated VanB-Type Glycopeptide Resistance in Enterococcus faecium Louis B. Rice, Lenore L. Carias, Curtis L. Donskey, and Susan D. Rudin Antimicrob. Agents Chemother. April 1998 42: 963-964; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Effect of Dirithromycin on Haemophilus influenzae Infection of the Respiratory Mucosa Andrew Rutman, Ruth Dowling, Peter Wills, Charles Feldman, Peter J. Cole, and Robert Wilson Antimicrob. Agents Chemother. April 1998 42: 772-778; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Activity of HSR-903, a New Fluoroquinolone, against Respiratory Pathogens Satoshi Yoshizumi, Haruki Domon, Shuichi Miyazaki, and Keizo Yamaguchi Antimicrob. Agents Chemother. April 1998 42: 785-788; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Imiquimod, a Patient-Applied Immune-Response Modifier for Treatment of External Genital Warts Karl R. Beutner, Stephen K. Tyring, Kenneth F. Trofatter, Jr., John M. Douglas, Jr., Spotswood Spruance, Mary L. Owens, Terry L. Fox, Andrina J. Hougham, and Kathy A. Schmitt Antimicrob. Agents Chemother. April 1998 42: 789-794; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Amoxicillin-Clavulanate against Penicillin-Resistant Streptococcus pneumoniae in an Experimental Respiratory Infection Model in Rats Gillian M. Smith, Brian Slocombe, Karen H. Abbott, and Linda W. Mizen Antimicrob. Agents Chemother. April 1998 42: 813-817; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prophylaxis of Acute Osteomyelitis with Absorbable Ofloxacin-Impregnated Beads David P. Nicolau, Lin Nie, Pamela R. Tessier, Helen P. Kourea, and Charles H. Nightingale Antimicrob. Agents Chemother. April 1998 42: 840-842; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Trovafloxacin against Penicillin-Susceptible and Multiresistant Strains of Streptococcus pneumoniae in a Mouse Pneumonia Model Jean-Pierre Bédos, Véronique Rieux, Jacqueline Bauchet, Martine Muffat-Joly, Claude Carbon, and Esther Azoulay-Dupuis Antimicrob. Agents Chemother. April 1998 42: 862-867; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of LY303366 against Amphotericin B-Susceptible and -Resistant Aspergillus fumigatus in a Murine Model of Invasive Aspergillosis Paul E. Verweij, Karen L. Oakley, Jacqui Morrissey, Graham Morrissey, and David W. Denning Antimicrob. Agents Chemother. April 1998 42: 873-878; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Fungizone, Amphotec, AmBisome, and Abelcet for Treatment of Systemic Murine Cryptococcosis Karl V. Clemons and David A. Stevens Antimicrob. Agents Chemother. April 1998 42: 899-902; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Sulfamethoxypyridazine in a Murine Model of Pneumocystis carinii Pneumonia Marilyn S. Bartlett, Margaret M. Shaw, James W. Smith, and Steven R. Meshnick Antimicrob. Agents Chemother. April 1998 42: 934-935; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antidermatophyte Activities of NND-502, a Novel Optically Active Imidazole Antimycotic Agent Yoshimi Niwano, Naoki Kuzuhara, Hiroki Kodama, Masanori Yoshida, Tsuneo Miyazaki, and Hideyo Yamaguchi Antimicrob. Agents Chemother. April 1998 42: 967-970; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of LY333328 against Experimental Methicillin-Resistant Staphylococcus aureus Endocarditis Glenn W. Kaatz, Susan M. Seo, Jeffrey R. Aeschlimann, Heather H. Houlihan, Renee-Claude Mercier, and Michael J. Rybak Antimicrob. Agents Chemother. April 1998 42: 981-983; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Generation and Characterization of a Mutant of Influenza A Virus Selected with the Neuraminidase Inhibitor BCX-140 Shanta Bantia, Anita A. Ghate, Sandya L. Ananth, Y. Sudhakar Babu, Gillian M. Air, and Gerald M. Walsh Antimicrob. Agents Chemother. April 1998 42: 801-807; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Zidovudine Pharmacokinetics in Premature Infants Exposed to Human Immunodeficiency Virus Mark Mirochnick, Edmund Capparelli, Wayne Dankner, Rhoda S. Sperling, Russ van Dyke, and Stephen A. Spector Antimicrob. Agents Chemother. April 1998 42: 808-812; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Relationship between Didanosine Exposure and Surrogate Marker Response in Human Immunodeficiency Virus-Infected Outpatients John M. Adams, Mark J. Shelton, Ross G. Hewitt, Thaddeus H. Grasela, Mary DeRemer, and Gene D. Morse Antimicrob. Agents Chemother. April 1998 42: 821-826; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Unique Metabolism of a Novel Antiviral L-Nucleoside Analog, 2'-Fluoro-5-Methyl--L-Arabinofuranosyluracil: a Substrate for Both Thymidine Kinase and Deoxycytidine Kinase Shwu-Huey Liu, Kristie L. Grove, and Yung-Chi Cheng Antimicrob. Agents Chemother. April 1998 42: 833-839; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England Jacqueline Christophers, Julie Clayton, John Craske, Rosemary Ward, Peter Collins, Martin Trowbridge, and Graham Darby Antimicrob. Agents Chemother. April 1998 42: 868-872; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Dual Inhibition of Human Rhinovirus 2A and 3C Proteases by Homophthalimides Q. May Wang, Robert B. Johnson, Louis N. Jungheim, Jeffrey D. Cohen, and Elcira C. Villarreal Antimicrob. Agents Chemother. April 1998 42: 916-920; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Human Cytomegalovirus Mutant with Sequence-Dependent Resistance to the Phosphorothioate Oligonucleotide Fomivirsen (ISIS 2922) Gilbert B. Mulamba, André Hu, Raana F. Azad, Kevin P. Anderson, and Donald M. Coen Antimicrob. Agents Chemother. April 1998 42: 971-973; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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Use of a Rapid Throughput In Vivo Screen To Investigate Inhibitors of Eukaryotic Topoisomerase II Enzymes Timothy R. Hammonds, Anthony Maxwell, and John R. Jenkins Antimicrob. Agents Chemother. April 1998 42: 889-894; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Activity of Voriconazole, a New Triazole, Combined with Neutrophils or Monocytes against Candida albicans: Effect of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor Shefali Vora, Nayanatara Purimetla, Elmer Brummer, and David A. Stevens Antimicrob. Agents Chemother. April 1998 42: 907-910; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Recent Approvals:

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New Antimicrobial Agents Approved by the U.S. Food and Drug Administration in 1997 and New Indications for Previously Approved Agents Antimicrob. Agents Chemother. April 1998 42: 987-988; [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Emergence of Erythromycin-Resistant, Clindamycin-Susceptible Streptococcus pyogenes Isolates in Madrid, Spain Isabel Garcia-Bermejo, Juana Cacho, Beatriz Orden, Juan-Ignacio Alós, and Jose-Luis Gómez-Garcés Antimicrob. Agents Chemother. April 1998 42: 989-990; [Full Text] [PDF] [Reprints and Permissions]

Synergistic Activity of Trovafloxacin and Ceftriaxone or Vancomycin against Streptococcus pneumoniae with Various Penicillin Susceptibilities David P. Nicolau, Pamela R. Tessier, Richard Quintiliani, and Charles H. Nightingale Antimicrob. Agents Chemother. April 1998 42: 991-992; [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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In Vitro Activity of a New Oral Triazole, BMS-207147 (ER-30346) Joan C. Fung-Tomc, Elizabeth Huczko, Beatrice Minassian, and Daniel P. Bonner Antimicrob. Agents Chemother. April 1998 42: 993 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.