Contents: June 1998, Volume 42, Issue 6        Minireviews        Pharmacology        Experimental Therapeutics        Mechanisms of Resistance        Clinical Therapeutics        Antiviral Agents        Susceptibility        Biologic Response Modifiers        Mechanisms of Action        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Treatment of Infection Due to Pneumocystis carinii Jay Alan Fishman Antimicrob. Agents Chemother. June 1998 42: 1309-1314; [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Phase I Safety and Pharmacokinetics Study of Micronized Atovaquone in Human Immunodeficiency Virus-Infected Infants and Children Walter Hughes, Alejandro Dorenbaum, Ram Yogev, Belinda Beauchamp, Jing Xu, James McNamara, John Moye, Lynette Purdue, Russell van Dyke, Michael Rogers, Brian Sadler, and The Pediatric Aids Clinical Trials Group Antimicrob. Agents Chemother. June 1998 42: 1315-1318; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Changes in MIC Alter Responses of Pseudomonas aeruginosa to Tobramycin Exposure L. L. Ioannides-Demos, L. Liolios, P. Wood, W. J. Spicer, and A. J. McLean Antimicrob. Agents Chemother. June 1998 42: 1365-1369; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Initial Concentration-Time Profile of Gentamicin Determines Efficacy against Enterobacter cloacae ATCC 13047 Craig R. Rayner, Lisa L. Ioannides-Demos, Jo-Anne E. Brien, Lisa L. Liolios, and W. John Spicer Antimicrob. Agents Chemother. June 1998 42: 1370-1374; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Assessment of Antifungal Activities of Fluconazole and Amphotericin B Administered Alone and in Combination against Candida albicans by Using a Dynamic In Vitro Mycotic Infection Model Russell E. Lewis, Brian C. Lund, Michael E. Klepser, Erika J. Ernst, and Michael A. Pfaller Antimicrob. Agents Chemother. June 1998 42: 1382-1386; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials Weiguo Liu, Qing Feng Liu, Ruth Perkins, George Drusano, Arnold Louie, Assumpta Madu, Umar Mian, Martin Mayers, and Michael H. Miller Antimicrob. Agents Chemother. June 1998 42: 1417-1423; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Safety of a New Parenteral Carbapenem Antibiotic, Biapenem (L-627), in Elderly Subjects Osamu Kozawa, Toshihiko Uematsu, Hiroyuki Matsuno, Masayuki Niwa, Yoshiharu Takiguchi, Syouzou Matsumoto, Masahiko Minamoto, Yoshito Niida, Masahiro Yokokawa, Satoru Nagashima, and Mitsutaka Kanamaru Antimicrob. Agents Chemother. June 1998 42: 1433-1436; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of the Pharmacokinetic Interaction between Cephalexin and Quinapril by a Nonlinear Mixed-Effect Model C. Padoin, M. Tod, G. Perret, and O. Petitjean Antimicrob. Agents Chemother. June 1998 42: 1463-1469; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chondrotoxicity and Toxicokinetics of Sparfloxacin in Juvenile Rats Ralf Stahlmann, Uta Zippel, Christian Förster, Rudolf Schwabe, Mehdi Shakibaei, Hans-Joachim Merker, and Klaus Borner Antimicrob. Agents Chemother. June 1998 42: 1470-1475; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Delivery of the Non-Membrane-Permeative Antibiotic Gentamicin into Mammalian Cells by Using Shigella flexneri Membrane Vesicles Jagath L. Kadurugamuwa and Terry J. Beveridge Antimicrob. Agents Chemother. June 1998 42: 1476-1483; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetic Studies of Fluconazole in Rabbits Characterizing Doses Which Achieve Peak Levels in Serum and Area under the Concentration-Time Curve Values Which Mimic Those of High-Dose Fluconazole in Humans Arnold Louie, Qing-Feng Liu, George L. Drusano, Weiguo Liu, Martin Mayers, Elias Anaissie, and Michael H. Miller Antimicrob. Agents Chemother. June 1998 42: 1512-1514; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Minocycline and Cefotaxime in the Treatment of Experimental Murine Vibrio vulnificus Infection Yin-Ching Chuang, Wen-Chien Ko, Shan-Tair Wang, Jien-Wei Liu, Chih-Feng Kuo, Jiunn-Jong Wu, and Kun-Yen Huang Antimicrob. Agents Chemother. June 1998 42: 1319-1322; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lysostaphin Treatment of Experimental Methicillin-Resistant Staphylococcus aureus Aortic Valve Endocarditis Michael W. Climo, Roberto L. Patron, Beth P. Goldstein, and Gordon L. Archer Antimicrob. Agents Chemother. June 1998 42: 1355-1360; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Efficacies of Amoxicillin and Cefuroxime against Penicillin-Resistant Streptococcus pneumoniae in a Gerbil Model of Acute Otitis Media Carlos Cenjor, Carmen Ponte, Araceli Parra, Eva Nieto, Gloria García-Calvo, María José Giménez, Lorenzo Aguilar, and Francisco Soriano Antimicrob. Agents Chemother. June 1998 42: 1361-1364; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Moxifloxacin in the Therapy of Experimental Pneumococcal Meningitis H. Schmidt, A. Dalhoff, K. Stuertz, F. Trostdorf, V. Chen, O. Schneider, C. Kohlsdorfer, W. Brück, and R. Nau Antimicrob. Agents Chemother. June 1998 42: 1397-1401; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Activity of 3'-Deoxyadenosine (Cordycepin) Alan M. Sugar and Ronald P. McCaffrey Antimicrob. Agents Chemother. June 1998 42: 1424-1427; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacies of Zinc-Finger-Active Drugs against Giardia lamblia Theodore Nash and William G. Rice Antimicrob. Agents Chemother. June 1998 42: 1488-1492; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Phenotypic Study of Resistance of -Lactamase-Inhibitor-Resistant TEM Enzymes Which Differ by Naturally Occurring Variations and by Site-Directed Substitution at Asp276 M. Manuela Caniça, Nathalie Caroff, Michel Barthélémy, Roger Labia, Rajagopal Krishnamoorthy, Gérard Paul, and Jean-Marie Dupret Antimicrob. Agents Chemother. June 1998 42: 1323-1328; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Alterations in PBP 1A Essential for High-Level Penicillin Resistance in Streptococcus pneumoniae Anthony M. Smith and Keith P. Klugman Antimicrob. Agents Chemother. June 1998 42: 1329-1333; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

-Lactamases Responsible for Resistance to Expanded-Spectrum Cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis Isolates Recovered in South Africa J. D. D. Pitout, K. S. Thomson, N. D. Hanson, A. F. Ehrhardt, E. S. Moland, and C. C. Sanders Antimicrob. Agents Chemother. June 1998 42: 1350-1354; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Recombinant Expression and Characterization of the Major -Lactamase of Mycobacterium tuberculosis Rama Kishan R. Voladri, David L. Lakey, Steven H. Hennigan, Barbara E. Menzies, Kathryn M. Edwards, and Douglas S. Kernodle Antimicrob. Agents Chemother. June 1998 42: 1375-1381; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New Ketolide, HMR 3004, Active against Streptococci Inducibly Resistant to Erythromycin Adriana Rosato, Hubert Vicarini, Alain Bonnefoy, Jean-François Chantot, and Roland Leclercq Antimicrob. Agents Chemother. June 1998 42: 1392-1396; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ceftazidime and Aztreonam Resistance in Providencia stuartii: Characterization of a Natural TEM-Derived ExtendedSpectrum -Lactamase, TEM-60 Nicola Franceschini, Mariagrazia Perilli, Bernardetta Segatore, Domenico Setacci, Gianfranco Amicosante, Annarita Mazzariol, and Giuseppe Cornaglia Antimicrob. Agents Chemother. June 1998 42: 1459-1462; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Different Erythromycin Resistance Mechanisms in Group C and Group G Streptococci Janne Kataja, Helena Seppälä, Mikael Skurnik, Hannu Sarkkinen, and Pentti Huovinen Antimicrob. Agents Chemother. June 1998 42: 1493-1494; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the 6'-N-Aminoglycoside Acetyltransferase Gene aac(6')-Iq from the Integron of a Natural Multiresistance Plasmid Daniela Centrón and Paul H. Roy Antimicrob. Agents Chemother. June 1998 42: 1506-1508; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of -Lactamases to -Lactam Susceptibilities of Susceptible and Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates C. Segura, M. Salvadó, I. Collado, J. Chaves, and A. Coira Antimicrob. Agents Chemother. June 1998 42: 1524-1526; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Effect of Metronidazole Resistance on Bacterial Eradication of Helicobacter pylori in Infected Children J. Raymond, N. Kalach, M. Bergeret, P. H. Benhamou, J. P. Barbet, D. Gendrel, and C. Dupont Antimicrob. Agents Chemother. June 1998 42: 1334-1335; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pregnancy Outcome Following Gestational Exposure to Fluoroquinolones: a Multicenter Prospective Controlled Study Ronen Loebstein, Antonio Addis, Elaine Ho, Roseann Andreou, Suzanne Sage, Alan E. Donnenfeld, Betsy Schick, Maurizio Bonati, Myla Moretti, Arieh Lalkin, Anne Pastuszak, and Gideon Koren Antimicrob. Agents Chemother. June 1998 42: 1336-1339; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Randomized Trial of Trimethoprim-Sulfamethoxazole versus Pyrimethamine-Sulfadiazine for Therapy of Toxoplasmic Encephalitis in Patients with AIDS Donato Torre, Salvatore Casari, Filippo Speranza, Alessandra Donisi, Giampietro Gregis, Antonio Poggio, Sergio Ranieri, Anna Orani, Gioacchino Angarano, Francesco Chiodo, GianPaolo Fiori, Giampiero Carosi, and the Italian Collaborative Study Group Antimicrob. Agents Chemother. June 1998 42: 1346-1349; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oral Antimicrobial Prophylaxis in Bone Marrow Transplant Recipients: Randomized Trial of Ciprofloxacin versus Ciprofloxacin-Vancomycin Clyde D. Ford, William Reilly, John Wood, David C. Classen, and John P. Burke Antimicrob. Agents Chemother. June 1998 42: 1402-1405; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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S-1153 Inhibits Replication of Known Drug-Resistant Strains of Human Immunodeficiency Virus Type 1 Tamio Fujiwara, Akihiko Sato, Mohamed El-Farrash, Shigeru Miki, Kenji Abe, Yoshitaka Isaka, Makoto Kodama, Yaming Wu, Lan Bo Chen, Hiroshi Harada, Hirohiko Sugimoto, Masakazu Hatanaka, and Yorio Hinuma Antimicrob. Agents Chemother. June 1998 42: 1340-1345; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Activities of 9-R-2-Phosphonomethoxypropyl Adenine (PMPA) and Bis(isopropyloxymethylcarbonyl)PMPA against Various Drug-Resistant Human Immunodeficiency Virus Strains Ranga V. Srinivas and Arnold Fridland Antimicrob. Agents Chemother. June 1998 42: 1484-1487; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Evaluation of Endpoints for Antifungal Susceptibility Determinations with LY303366 Michael E. Klepser, Erika J. Ernst, Michael E. Ernst, Shawn A. Messer, and Michael A. Pfaller Antimicrob. Agents Chemother. June 1998 42: 1387-1391; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Antibiotic Susceptibility Tests by the ATP-Bioluminescence Method Using Filamentous Cell Treatment Noriaki Hattori, Moto-O Nakajima, Koji O'Hara, and Tetsuo Sawai Antimicrob. Agents Chemother. June 1998 42: 1406-1411; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of In Vitro Antifungal Activities of Free and Liposome-Encapsulated Nystatin with Those of Four Amphotericin B Formulations Elizabeth M. Johnson, Joshua O. Ojwang, Adrien Szekely, Thomas L. Wallace, and David W. Warnock Antimicrob. Agents Chemother. June 1998 42: 1412-1416; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of a Continuous-Culture Biofilm System To Study the Antimicrobial Susceptibilities of Gardnerella vaginalis and Lactobacillus acidophilus F. Muli and J. K. Struthers Antimicrob. Agents Chemother. June 1998 42: 1428-1432; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Screening for Novel Antimicrobials from Encoded Combinatorial Libraries by Using a Two-Dimensional Agar Format Joy L. Silen, Amy T. Lu, Dennis W. Solas, Medini A. Gore, Derek Maclean, Nikil H. Shah, Jill M. Coffin, Naseema S. Bhinderwala, Yongwen Wang, Ken T. Tsutsui, Gary C. Look, David A. Campbell, Ron L. Hale, Marc Navre, and Camille R. DeLuca-Flaherty Antimicrob. Agents Chemother. June 1998 42: 1447-1453; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic Effect of Trovafloxacin against Gram-Positive and -Negative Organisms G. A. Pankuch, M. R. Jacobs, and P. C. Appelbaum Antimicrob. Agents Chemother. June 1998 42: 1503-1505; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the New Ketolide Antibiotics HMR 3004 and HMR 3647 against Streptococcus pneumoniae in Germany Ralf René Reinert, André Bryskier, and Rudolf Lütticken Antimicrob. Agents Chemother. June 1998 42: 1509-1511; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of a New Ketolide Antibiotic, HMR 3647, against Chlamydia pneumoniae Patricia M. Roblin and Margaret R. Hammerschlag Antimicrob. Agents Chemother. June 1998 42: 1515-1516; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibilities of Group B Streptococci Isolated between 1992 and 1996 from Patients with Bacteremia or Meningitis Marisol Fernandez, Melissa E. Hickman, and Carol J. Baker Antimicrob. Agents Chemother. June 1998 42: 1517-1519; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibilities of Legionella spp. to Newer Antimicrobials In Vitro T. Schülin, C. B. Wennersten, M. J. Ferraro, R. C. Moellering, Jr., and G. M. Eliopoulos Antimicrob. Agents Chemother. June 1998 42: 1520-1523; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Characterization of a Murine Monoclonal Antibody to Cryptococcus neoformans Polysaccharide That Is a Candidate for Human Therapeutic Studies Arturo Casadevall, Wendy Cleare, Marta Feldmesser, Aharona Glatman-Freedman, David L. Goldman, Thomas R. Kozel, Nikoletta Lendvai, Jean Mukherjee, Liise-anne Pirofski, Johanna Rivera, Angel L. Rosas, Matthew D. Scharff, Philippe Valadon, Katherine Westin, and Zhaojing Zhong Antimicrob. Agents Chemother. June 1998 42: 1437-1446; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Roxithromycin Inhibits Cytokine Production by and Neutrophil Attachment to Human Bronchial Epithelial Cells In Vitro Shin Kawasaki, Hajime Takizawa, Takayuki Ohtoshi, Naonobu Takeuchi, Tadashi Kohyama, Hidenori Nakamura, Tsuyoshi Kasama, Kazuo Kobayashi, Kazuhiko Nakahara, Yutaka Morita, and Kazuhiko Yamamoto Antimicrob. Agents Chemother. June 1998 42: 1499-1502; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Quantitative Structure-Activity Relationship Studies of a Series of Sulfa Drugs as Inhibitors of Pneumocystis carinii Dihydropteroate Synthetase Theresa Johnson, Ikhlas A. Khan, Mitchell A. Avery, Juliana Grant, and Steven R. Meshnick Antimicrob. Agents Chemother. June 1998 42: 1454-1458; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mode of Action of Sulfanilyl Fluoroquinolones Fabiana Alovero, Marcelo Nieto, Maria Rosa Mazzieri, Rudolf Then, and Ruben H. Manzo Antimicrob. Agents Chemother. June 1998 42: 1495-1498; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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In Vitro and In Vivo Antibacterial Activities of CS-834, a New Oral Carbapenem Keizo Yamaguchi, Haruki Domon, Shuichi Miyazaki, Kazuhiro Tateda, Akira Ohno, Yoshikazu Ishii, Tetsuya Matsumoto, and Nobuhiko Furuya Antimicrob. Agents Chemother. June 1998 42: 1527 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.