Contents: August 1998, Volume 42, Issue 8        Minireviews        Pharmacology        Mechanisms of Resistance        Biologic Response Modifiers        Analytical Procedures        Experimental Therapeutics        Susceptibility        Mechanisms of Action        Chemistry; Biosynthesis        Antiviral Agents        Clinical Therapeutics        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Tn916 Family Conjugative Transposons and Dissemination of Antimicrobial Resistance Determinants Louis B. Rice Antimicrob. Agents Chemother. August 1998 42: 1871-1877; [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Plasma Lipoprotein Distribution of Liposomal Nystatin Is Influenced by Protein Content of High-Density Lipoproteins Shawn M. Cassidy, Frank W. Strobel, and Kishor M. Wasan Antimicrob. Agents Chemother. August 1998 42: 1878-1888; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interactions between HMR 3647, a New Ketolide, and Human Polymorphonuclear Neutrophils D. Vazifeh, A. Preira, A. Bryskier, and M. T. Labro Antimicrob. Agents Chemother. August 1998 42: 1944-1951; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo Activity and Pharmacokinetic Evaluation of a Novel Long-Acting Carbapenem Antibiotic, MK-826 (L-749,345) Charles J. Gill, Jesse J. Jackson, Lynn S. Gerckens, Barbara A. Pelak, Randall K. Thompson, Jon G. Sundelof, Helmut Kropp, and H. Rosen Antimicrob. Agents Chemother. August 1998 42: 1996-2001; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Disposition and Elimination of Meropenem in Cerebrospinal Fluid of Hydrocephalic Patients with External Ventriculostomy Roland Nau, Christoph Lassek, Martina Kinzig-Schippers, Andreas Thiel, Hilmar W. Prange, and Fritz Sörgel Antimicrob. Agents Chemother. August 1998 42: 2012-2016; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Rifabutin in Human Immunodeficiency Virus-Infected Patients Giorgio Gatti, Pietro Papa, Donato Torre, Massimo Andreoni, Antonio Poggio, Matteo Bassetti, and Piero Marone Antimicrob. Agents Chemother. August 1998 42: 2017-2023; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of [18F]Trovafloxacin in Healthy Human Subjects Studied with Positron Emission Tomography Alan J. Fischman, John W. Babich, Ali A. Bonab, Nathaniel M. Alpert, John Vincent, Ronald J. Callahan, John A. Correia, and Robert H. Rubin Antimicrob. Agents Chemother. August 1998 42: 2048-2054; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics, Safety, and Tolerability of Ascending Single Doses of Moxifloxacin, a New 8-Methoxy Quinolone, Administered to Healthy Subjects H. Stass, A. Dalhoff, D. Kubitza, and U. Schühly Antimicrob. Agents Chemother. August 1998 42: 2060-2065; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Y-688, a New Quinolone Active against Quinolone-Resistant Staphylococcus aureus: Lack of In Vivo Efficacy in Experimental Endocarditis J. M. Entenza, O. Marchetti, M. P. Glauser, and P. Moreillon Antimicrob. Agents Chemother. August 1998 42: 1889-1894; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Growth Rate on Resistance of Candida albicans Biofilms to Antifungal Agents George S. Baillie and L. Julia Douglas Antimicrob. Agents Chemother. August 1998 42: 1900-1905; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Activity of Gatifloxacin (AM-1155, CG5501, BMS-206584), a Newly Developed Fluoroquinolone, against Sequentially Acquired Quinolone-Resistant Mutants and the norA Transformant of Staphylococcus aureus Hideyuki Fukuda, Satoshi Hori, and Keiichi Hiramatsu Antimicrob. Agents Chemother. August 1998 42: 1917-1922; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Cloning and Functional Analysis of a Novel Tetracycline Resistance Determinant, tet(V), from Mycobacterium smegmatis Edda De Rossi, Marian C. J. Blokpoel, Rita Cantoni, Manuela Branzoni, Giovanna Riccardi, Douglas B. Young, Koen A. L. De Smet, and Orio Ciferri Antimicrob. Agents Chemother. August 1998 42: 1931-1937; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the MexC-MexD-OprJ Multidrug Efflux System in mexA-mexB-oprM Mutants of Pseudomonas aeruginosa Naomasa Gotoh, Hideto Tsujimoto, Masataka Tsuda, Kiyomi Okamoto, Atsuko Nomura, Takaomi Wada, Masaaki Nakahashi, and Takeshi Nishino Antimicrob. Agents Chemother. August 1998 42: 1938-1943; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Site-Specific Mutations in the 23S rRNA Gene of Helicobacter pylori Confer Two Types of Resistance to Macrolide-Lincosamide-Streptogramin B Antibiotics Ge Wang and Diane E. Taylor Antimicrob. Agents Chemother. August 1998 42: 1952-1958; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Structure of CARB-4 and AER-1 CarbenicillinHydrolyzing -Lactamases François Sanschagrin, Noureddine Bejaoui, and Roger C. Levesque Antimicrob. Agents Chemother. August 1998 42: 1966-1972; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

CTX-M-5, a Novel Cefotaxime-Hydrolyzing -Lactamase from an Outbreak of Salmonella typhimurium in Latvia Patricia A. Bradford, Youjun Yang, Daniel Sahm, Ilze Grope, Dace Gardovska, and Gregory Storch Antimicrob. Agents Chemother. August 1998 42: 1980-1984; [Abstract] [Full Text] [Reprints and Permissions]

Sensitivity of Leishmania viannia panamensis to Pentavalent Antimony Is Correlated with the Formation of Cleavable DNA-Protein Complexes Armando Lucumi, Sara Robledo, Vivian Gama, and Nancy G. Saravia Antimicrob. Agents Chemother. August 1998 42: 1990-1995; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Detection and Evaluation of Clinical Characteristics of Emerging Multiple-Drug-Resistant Gram-Negative Rods Carrying the Metallo--Lactamase Gene blaIMP Yoichi Hirakata, Koichi Izumikawa, Toshiyuki Yamaguchi, Hiromu Takemura, Hironori Tanaka, Ryoji Yoshida, Junichi Matsuda, Michiko Nakano, Kazunori Tomono, Shigefumi Maesaki, Mitsuo Kaku, Yasuaki Yamada, Shimeru Kamihira, and Shigeru Kohno Antimicrob. Agents Chemother. August 1998 42: 2006-2011; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cloning and Nucleotide Sequences of the Topoisomerase IV parC and parE Genes of Mycoplasma hominis Cécile M. Bébéar, Alain Charron, Joseph Marie Bové, Christiane Bébéar, and Joel Renaudin Antimicrob. Agents Chemother. August 1998 42: 2024-2031; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of a Putative Efflux Mechanism among Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae Nigel P. Brenwald, Martin J. Gill, and Richard Wise Antimicrob. Agents Chemother. August 1998 42: 2032-2035; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

vanA Gene Cluster in a Vancomycin-Resistant Clinical Isolate of Bacillus circulans Marco Ligozzi, Giuliana Lo Cascio, and Roberta Fontana Antimicrob. Agents Chemother. August 1998 42: 2055-2059; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of OXA-20, a Novel Class D -Lactamase, and Its Integron from Pseudomonas aeruginosa Thierry Naas, Wladimir Sougakoff, Anne Casetta, and Patrice Nordmann Antimicrob. Agents Chemother. August 1998 42: 2074-2083; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Correlation between Quinolone Susceptibility Patterns and Sequences in the A and B Subunits of DNA Gyrase in Mycobacteria Isabelle Guillemin, Vincent Jarlier, and Emmanuelle Cambau Antimicrob. Agents Chemother. August 1998 42: 2084-2088; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Overexpression of the marA or soxS Regulatory Gene in Clinical Topoisomerase Mutants of Escherichia coli Margret Oethinger, Isabelle Podglajen, Winfried V. Kern, and Stuart B. Levy Antimicrob. Agents Chemother. August 1998 42: 2089-2094; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of Novel Mutation Patterns in the parC Gene of Ciprofloxacin-Resistant Isolates of Neisseria gonorrhoeae David L. Trees, Amy L. Sandul, William L. Whittington, and Joan S. Knapp Antimicrob. Agents Chemother. August 1998 42: 2103-2105; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Mutations in GrlA of Topoisomerase IV from Staphylococcus aureus on Quinolone and Coumarin Activity Bénédicte Fournier and David C. Hooper Antimicrob. Agents Chemother. August 1998 42: 2109-2112; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Tn5706, a Transposon-Like Element from Pasteurella multocida Mediating Tetracycline Resistance Corinna Kehrenberg, Christiane Werckenthin, and Stefan Schwarz Antimicrob. Agents Chemother. August 1998 42: 2116-2118; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Active Efflux of Norfloxacin by Bacteroides fragilis Shin Miyamae, Hiroshi Nikaido, Yoshinobu Tanaka, and Fuminobu Yoshimura Antimicrob. Agents Chemother. August 1998 42: 2119-2121; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Topoisomerase Mutations in Trovafloxacin-Resistant Staphylococcus aureus Joseph E. Fitzgibbon, Joseph F. John, Jennifer L. Delucia, and Donald T. Dubin Antimicrob. Agents Chemother. August 1998 42: 2122-2124; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of a TEM-21 -Lactamase in a Clinical Isolate of Morganella morganii F. Tessier, C. Arpin, A. Allery, and C. Quentin Antimicrob. Agents Chemother. August 1998 42: 2125-2127; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Confirmatory Evidence from 18S rRNA Gene Analysis for In Vivo Development of Propamidine Resistance in a Temporal Series of Acanthamoeba Ocular Isolates from a Patient Dolena R. Ledee, David V. Seal, and Thomas J. Byers Antimicrob. Agents Chemother. August 1998 42: 2144-2145; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Effect of Rebamipide, a Novel Antiulcer Agent, on Helicobacter pylori Adhesion to Gastric Epithelial Cells Shunji Hayashi, Toshiro Sugiyama, Ken-Ichi Amano, Hiroshi Isogai, Emiko Isogai, Miki Aihara, Mikio Kikuchi, Masahiro Asaka, Kenji Yokota, Keiji Oguma, Nobuhiro Fujii, and Yoshikazu Hirai Antimicrob. Agents Chemother. August 1998 42: 1895-1899; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Immunomodulating Properties of the Antibiotic Novobiocin in Human Monocytes Anja Lührmann, Jürgen Thölke, Ingrid Behn, Jens Schumann, Gisa Tiegs, and Sunna Hauschildt Antimicrob. Agents Chemother. August 1998 42: 1911-1916; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ciprofloxacin Induces an Immunomodulatory Stress Response in Human T Lymphocytes Kristian Riesbeck, Arne Forsgren, Agnethe Henriksson, and Anders Bredberg Antimicrob. Agents Chemother. August 1998 42: 1923-1930; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Analytical Procedures:

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Generation of Bioluminescent Streptococcus mutans and Its Usage in Rapid Analysis of the Efficacy of Antimicrobial Compounds Vuokko Loimaranta, Jorma Tenovuo, Leeni Koivisto, and Matti Karp Antimicrob. Agents Chemother. August 1998 42: 1906-1910; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Efficacy of Nitazoxanide against Cryptosporidium parvum in Cell Culture and in Animal Models Cynthia M. Theodos, Jeffrey K. Griffiths, Jennifer D'Onfro, Alexandra Fairfield, and Saul Tzipori Antimicrob. Agents Chemother. August 1998 42: 1959-1965; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of MK-991 (L-743,872), a Semisynthetic Pneumocandin, in Murine Models of Pneumocystis carinii Mary Ann Powles, Paul Liberator, Jennifer Anderson, Yashwant Karkhanis, James F. Dropinski, F. Aileen Bouffard, James M. Balkovec, Hisashi Fujioka, Masamichi Aikawa, Diane McFadden, and Dennis Schmatz Antimicrob. Agents Chemother. August 1998 42: 1985-1989; [Abstract] [Full Text] [Reprints and Permissions]

In Vitro and In Vivo Activities of Moxifloxacin and Clinafloxacin against Mycobacterium tuberculosis Baohong Ji, Nacer Lounis, Caroline Maslo, Chantal Truffot-Pernot, Pascale Bonnafous, and Jacques Grosset Antimicrob. Agents Chemother. August 1998 42: 2066-2069; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro Activities of Oral -Lactams at Concentrations Achieved in Humans against Penicillin-Susceptible and -Resistant Pneumococci and Potential to Select Resistance Christine E. Thorburn, Sarah J. Knott, and David I. Edwards Antimicrob. Agents Chemother. August 1998 42: 1973-1979; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Three Quinolones, Alone and in Combination with Extended-Spectrum Cephalosporins or Gentamicin, against Stenotrophomonas maltophilia Melissa A. Visalli, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. August 1998 42: 2002-2005; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibility of Mycobacterium ulcerans to Clarithromycin F. Portaels, H. Traore, K. De Ridder, and W. M. Meyers Antimicrob. Agents Chemother. August 1998 42: 2070-2073; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Resistance of Clinical Strains of Campylobacter jejuni subsp. jejuni Isolated from 1985 to 1997 in Quebec, Canada Christiane Gaudreau and Huguette Gilbert Antimicrob. Agents Chemother. August 1998 42: 2106-2108; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the Ketolide HMR 3647 against Recent Gram-Positive Clinical Isolates and Haemophilus influenzae Arthur L. Barry, Peter C. Fuchs, and Steven D. Brown Antimicrob. Agents Chemother. August 1998 42: 2138-2140; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Iron-Limited Biofilms of Candida albicans and Their Susceptibility to Amphotericin B George S. Baillie and L. Julia Douglas Antimicrob. Agents Chemother. August 1998 42: 2146-2149; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Paclitaxel Arrests Growth of Intracellular Toxoplasma gondii Randee Estes, Nicolas Vogel, Douglas Mack, and Rima McLeod Antimicrob. Agents Chemother. August 1998 42: 2036-2040; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Acquisition of Certain Streptomycin-Resistant (str) Mutations Enhances Antibiotic Production in Bacteria Yoshiko Hosoya, Susumu Okamoto, Hideyuki Muramatsu, and Kozo Ochi Antimicrob. Agents Chemother. August 1998 42: 2041-2047; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Mode of Action of (1'S,2'R)-9-{[1',2'-Bis(hydroxymethyl) cycloprop-1'-yl]methyl}guanine (A-5021) against Herpes Simplex Virus Type 1 and Type 2 and Varicella-Zoster Virus Nobukazu Ono, Satoshi Iwayama, Katsuya Suzuki, Takaaki Sekiyama, Harumi Nakazawa, Takashi Tsuji, Masahiko Okunishi, Tohru Daikoku, and Yukihiro Nishiyama Antimicrob. Agents Chemother. August 1998 42: 2095-2102; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of Human Immunodeficiency Virus Type 1 Infection in SCID-hu Thy/Liv Mice by the G-Quartet-Forming Oligonucleotide, ISIS 5320 Cheryl A. Stoddart, Linda Rabin, Mara Hincenbergs, Mary e. Moreno, Valerie Linquist-Stepps, Janet M. Leeds, Lo Anne Truong, J. R. Wyatt, David J. Ecker, and Joseph M. McCune Antimicrob. Agents Chemother. August 1998 42: 2113-2115; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The M539V Polymerase Variant of Human Hepatitis B Virus Demonstrates Resistance to 2'-Deoxy-3'-Thiacytidine and a Reduced Ability to Synthesize Viral DNA Stephanie K. Ladner, Thomas J. Miller, and Robert W. King Antimicrob. Agents Chemother. August 1998 42: 2128-2131; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Long-Term Therapy with the Guanine Nucleoside Analog Penciclovir Controls Chronic Duck Hepatitis B Virus Infection In Vivo Enjarn Lin, Carolyn Luscombe, Danni Colledge, Yan Yan Wang, and Stephen Locarnini Antimicrob. Agents Chemother. August 1998 42: 2132-2137; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Leishmania infantum: Lack of Parasite Resistance to Amphotericin B in a Clinically Resistant Visceral Leishmaniasis Remy Durand, Muriel Paul, Francine Pratlong, Daniele Rivollet, Marie-Laure Dubreuil-Lemaire, Rene Houin, Alain Astier, and Michele Deniau Antimicrob. Agents Chemother. August 1998 42: 2141-2143; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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First Report of the Isolation of High-Level Vancomycin-Resistant Enterococcus faecium from a Patient in Japan Naohisa Fujita, Manabu Yoshimura, Toshiaki Komori, Koichi Tanimoto, and Yasuyoshi Ike Antimicrob. Agents Chemother. August 1998 42: 2150 [Full Text] [PDF] [Reprints and Permissions]

Possible Link between Bacterial Resistance and Use of Antibiotics and Biocides A. D. Russell, Unchalee Tattawasart, J.-Y. Maillard, and J. R. Furr Antimicrob. Agents Chemother. August 1998 42: 2151 [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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Activity of Voriconazole, a New Triazole, Combined with Neutrophils or Monocytes against Candida albicans: Effect of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor Shefali Vora, Nayanatara Purimetla, Elmer Brummer, and David A. Stevens Antimicrob. Agents Chemother. August 1998 42: 2152 [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Killing Activities of Meropenem, Imipenem, Ceftriaxone, and Ceftriaxone plus Vancomycin at Clinically Achievable Cerebrospinal Fluid Concentrations against Penicillin-Resistant Streptococcus pneumoniae Isolates from Children with Meningitis Frederic Fitoussi, Catherine Doit, Karim Benali, Stephane Bonacorsi, Pierre Geslin, and Edouard Bingen Antimicrob. Agents Chemother. August 1998 42: 2152 [Full Text] [PDF] [Reprints and Permissions]

New Antimicrobial Agents Approved by the U.S. Food and Drug Administration in 1997 and New Indications for Previously Approved Agents Antimicrob. Agents Chemother. August 1998 42: 2152 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.