Contents: October 1999, Volume 43, Issue 10        Minireviews        Pharmacology        Antiviral Agents        Experimental Therapeutics        Mechanisms of Resistance        Susceptibility        Mechanisms of Action        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Lack of Cell Wall Peptidoglycan versus Penicillin Sensitivity: New Insights into the Chlamydial Anomaly Jean-Marie Ghuysen and Colette Goffin Antimicrob. Agents Chemother. October 1999 43: 2339-2344; [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Penetration of Moxifloxacin into Peripheral Compartments in Humans Markus Müller, Heino Staß, Martin Brunner, Jan G. Möller, Edith Lackner, and Hans G. Eichler Antimicrob. Agents Chemother. October 1999 43: 2345-2349; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Isepamicin during Continuous Venovenous Hemodiafiltration Dominique Breilh, Bernard Allaouchiche, Hélène Jaumain, Paul Boulétreau, Dominique Chassard, Isabelle Malbec, Dominique Ducint, and Marie-Claude Saux Antimicrob. Agents Chemother. October 1999 43: 2409-2411; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics and Absolute Bioavailability of Ribavirin in Healthy Volunteers as Determined by Stable-Isotope Methodology Sandra L. Preston, George L. Drusano, Paul Glue, Jacqueline Nash, S. K. Gupta, and P. McNamara Antimicrob. Agents Chemother. October 1999 43: 2451-2456; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The New Ketolide HMR3647 Accumulates in the Azurophil Granules of Human Polymorphonuclear Cells Christine Miossec-Bartoli, Lydie Pilatre, Pascale Peyron, Elsa-Noah N'Diaye, Véronique Collart-Dutilleul, Isabelle Maridonneau-Parini, and Anita Diu-Hercend Antimicrob. Agents Chemother. October 1999 43: 2457-2462; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of Pharmacodynamic Indices To Predict Efficacy of Combination Therapy In Vivo Johan W. Mouton, Marc L. van Ogtrop, David Andes, and William A. Craig Antimicrob. Agents Chemother. October 1999 43: 2473-2478; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Cilastatin on the Pharmacokinetics of a New Carbapenem, DA-1131, in Rats, Rabbits, and Dogs So H. Kim, Jong W. Kwon, Won B. Kim, and Myung G. Lee Antimicrob. Agents Chemother. October 1999 43: 2524-2527; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing J. Lipman, S. C. Wallis, and C. Rickard Antimicrob. Agents Chemother. October 1999 43: 2559-2561; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lipoprotein Distribution of a Novel Endotoxin Antagonist, E5531, in Plasma from Human Subjects with Various Lipid Levels Kishor M. Wasan, Frank W. Strobel, Steven C. Parrott, Melvyn Lynn, William J. Christ, Lynn D. Hawkins, and Daniel P. Rossignol Antimicrob. Agents Chemother. October 1999 43: 2562-2564; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Inhibition of Human Immunodeficiency Virus Type 1 Replication in Acutely and Chronically Infected Cells by EM2487, a Novel Substance Produced by a Streptomyces Species Masanori Baba, Mika Okamoto, and Hitoshi Takeuchi Antimicrob. Agents Chemother. October 1999 43: 2350-2355; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Action and In Vitro Activity of 1',3'-Dioxolanylpurine Nucleoside Analogues against Sensitive and Drug-Resistant Human Immunodeficiency Virus Type 1 Variants Zhengxian Gu, Mark A. Wainberg, Nghe Nguyen-Ba, Lucille L'Heureux, Jean-Marc de Muys, Terry L. Bowlin, and Robert F. Rando Antimicrob. Agents Chemother. October 1999 43: 2376-2382; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phenotypic and Genetic Characterization of Thymidine Kinase from Clinical Strains of Varicella-Zoster Virus Resistant to Acyclovir Florence Morfin, Danielle Thouvenot, Mireille De Turenne-Tessier, Bruno Lina, Michèle Aymard, and Tadamasa Ooka Antimicrob. Agents Chemother. October 1999 43: 2412-2416; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease A. K. Patick, S. L. Binford, M. A. Brothers, R. L. Jackson, C. E. Ford, M. D. Diem, F. Maldonado, P. S. Dragovich, R. Zhou, T. J. Prins, S. A. Fuhrman, J. W. Meador, L. S. Zalman, D. A. Matthews, and S. T. Worland Antimicrob. Agents Chemother. October 1999 43: 2444-2450; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Induction of Human Immunodeficiency Virus Type 1 Variants Resistant to Phosphoralaninate Prodrugs of Z-Methylenecyclopropane Nucleoside Analogues Kazuhisa Yoshimura, Ron Feldman, Eiichi Kodama, Mark F. Kavlick, Yao-Ling Qiu, Jiri Zemlicka, and Hiroaki Mitsuya Antimicrob. Agents Chemother. October 1999 43: 2479-2483; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Kaposi's Sarcoma and Antiangiogenic Activities of Sulfated Dextrins Mark Thornton, Laura Barkley, Justin C. Mason, and Sunil Shaunak Antimicrob. Agents Chemother. October 1999 43: 2528-2533; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Evaluation of Rifapentine in Long-Term Treatment Regimens for Tuberculosis in Mice Anne M. J. A. Lenaerts, Sharon E. Chase, Alex J. Chmielewski, and Michael H. Cynamon Antimicrob. Agents Chemother. October 1999 43: 2356-2360; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Antibiotic Therapy on Pseudomonas aeruginosa-Induced Lung Injury in a Rat Model Erika J. Ernst, Satoru Hashimoto, Joseph Guglielmo, Teiji Sawa, Jean-Francois Pittet, Helmut Kropp, Jesse J. Jackson, and Jeanine P. Wiener-Kronish Antimicrob. Agents Chemother. October 1999 43: 2389-2394; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety and Efficacy of Multilamellar Liposomal Nystatin against Disseminated Candidiasis in Persistently Neutropenic Rabbits Andreas H. Groll, Vidmantas Petraitis, Ruta Petraitiene, Aida Field-Ridley, Myrna Calendario, John Bacher, Stephen C. Piscitelli, and Thomas J. Walsh Antimicrob. Agents Chemother. October 1999 43: 2463-2467; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of a New Experimental Model of Penicillin-Resistant Streptococcus pneumoniae Pneumonia and Amoxicillin Treatment by Reproducing Human Pharmacokinetics Lionel Piroth, Laurent Martin, Alexis Coulon, Catherine Lequeu, Michel Duong, Marielle Buisson, Henri Portier, and Pascal Chavanet Antimicrob. Agents Chemother. October 1999 43: 2484-2492; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Treatment of Experimental Staphylococcal Endocarditis Due to a Strain with Reduced Susceptibility In Vitro to Vancomycin: Efficacy of Ampicillin-Sulbactam Mirjana Backo, Eliza Gaenger, Anna Burkart, Yin Li Chai, and Arnold S. Bayer Antimicrob. Agents Chemother. October 1999 43: 2565-2568; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Molecular Basis of Rifampin Resistance in Streptococcus pneumoniae Thanugarani Padayachee and Keith P. Klugman Antimicrob. Agents Chemother. October 1999 43: 2361-2365; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the Chromosomal aac(6')-Iz Gene of Stenotrophomonas maltophilia Thierry Lambert, Marie-Cécile Ploy, François Denis, and Patrice Courvalin Antimicrob. Agents Chemother. October 1999 43: 2366-2371; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Plasmid-Mediated Resistance to Thrombin-Induced Platelet Microbicidal Protein in Staphylococci: Role of the qacA Locus Leon Iri Kupferwasser, Ronald A. Skurray, Melissa H. Brown, Neville Firth, Michael R. Yeaman, and Arnold S. Bayer Antimicrob. Agents Chemother. October 1999 43: 2395-2399; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Mutations in the rpoB Gene in Naturally Rifampin-Resistant Rickettsia Species Michel Drancourt and Didier Raoult Antimicrob. Agents Chemother. October 1999 43: 2400-2403; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Cloning of the gyrA and gyrB Genes of Bacteroides fragilis Encoding DNA Gyrase Yoshikuni Onodera and Kenichi Sato Antimicrob. Agents Chemother. October 1999 43: 2423-2429; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Propagation of TEM- and PSE-Type -Lactamases among Amoxicillin-Resistant Salmonella spp. Isolated in France Catherine Llanes, Veronique Kirchgesner, and Patrick Plesiat Antimicrob. Agents Chemother. October 1999 43: 2430-2436; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sparfloxacin Selects Gyrase Mutations in First-Step Mycoplasma hominis Mutants, whereas Ofloxacin Selects Topoisonmerase IV Mutations George E. Kenny, Patrick A. Young, Frank D. Cartwright, Karen E. Sjöström, and Wai M. Huang Antimicrob. Agents Chemother. October 1999 43: 2493-2496; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Patterns of Macrolide Resistance Determinants among Community-Acquired Streptococcus pneumoniae Isolates over a 5-Year Period of Decreased Macrolide Susceptibility Rates Philipp Oster, Alessandra Zanchi, Stefania Cresti, Maria Lattanzi, Francesca Montagnani, Carla Cellesi, and Gian Maria Rossolini Antimicrob. Agents Chemother. October 1999 43: 2510-2512; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Association of Alterations in ParC and GyrA Proteins with Resistance of Clinical Isolates of Enterococcus faecium to Nine Different Fluoroquinolones Sylvain Brisse, Ad C. Fluit, Ulrich Wagner, Peter Heisig, Dana Milatovic, Jan Verhoef, Sybille Scheuring, Karl Köhrer, and Franz-Josef Schmitz Antimicrob. Agents Chemother. October 1999 43: 2513-2516; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Drug Efflux and parC Mutations Are Involved in Fluoroquinolone Resistance in Viridans Group Streptococci María José Ferrándiz, Jesús Oteo, Belén Aracil, Jose Luis Gómez-Garcés, and Adela G. De La Campa Antimicrob. Agents Chemother. October 1999 43: 2520-2523; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reconstruction of an Active Integron Recombination Site after Integration of a Gene Cassette at a Secondary Site Heidi Segal, M. Victoria Francia, Juan M. García Lobo, and Gay Elisha Antimicrob. Agents Chemother. October 1999 43: 2538-2541; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Detection of Rifampin Resistance in Mycobacterium tuberculosis by Double Gradient-Denaturing Gradient Gel Electrophoresis Paolo Scarpellini, Sergio Braglia, Paola Carrera, Maura Cedri, Paola Cichero, Alessia Colombo, Rosella Crucianelli, Andrea Gori, Maurizio Ferrari, and Adriano Lazzarin Antimicrob. Agents Chemother. October 1999 43: 2550-2554; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Killing Activities of Trovafloxacin Alone and in Combination with -Lactam Agents, Rifampin, or Vancomycin against Streptococcus pneumoniae Isolates with Various Susceptibilities to Extended-Spectrum Cephalosporins at Concentrations Clinically Achievable in Cerebrospinal Fluid Frederic Fitoussi, Catherine Doit, Pierre Geslin, and Edouard Bingen Antimicrob. Agents Chemother. October 1999 43: 2372-2375; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

-Lactamase Production in Prevotella intermedia, Prevotella nigrescens, and Prevotella pallens Genotypes and In Vitro Susceptibilities to Selected Antimicrobial Agents Jaana Mättö, Sirkka Asikainen, Marja-Liisa Väisänen, Birgitta Von Troil-Lindén, Eija Könönen, Maria Saarela, Kari Salminen, Sydney M. Finegold, and Hannele Jousimies-Somer Antimicrob. Agents Chemother. October 1999 43: 2383-2388; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus Penelope N. Markham, Eric Westhaus, Katya Klyachko, Michael E. Johnson, and Alex A. Neyfakh Antimicrob. Agents Chemother. October 1999 43: 2404-2408; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multicenter Study of In Vitro Susceptibility of the Bacteroides fragilis Group, 1995 to 1996, with Comparison of Resistance Trends from 1990 to 1996 D. R. Snydman, N. V. Jacobus, L. A. McDermott, S. Supran, G. J. Cuchural, Jr., S. Finegold, L. Harrell, D. W. Hecht, P. Iannini, S. Jenkins, Carl Pierson, J. Rihs, and S. L. Gorbach Antimicrob. Agents Chemother. October 1999 43: 2417-2422; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Carbapenem Derivatives as Potential Inhibitors of Various -Lactamases, Including Class B Metallo--Lactamases Rie Nagano, Yuka Adachi, Hideaki Imamura, Koji Yamada, Terutaka Hashizume, and Hajime Morishima Antimicrob. Agents Chemother. October 1999 43: 2497-2503; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Prevalence of Antimicrobial Resistance in Respiratory Tract Isolates of Streptococcus pneumoniae: Results of a Canadian National Surveillance Study George G. Zhanel, James A. Karlowsky, Lorraine Palatnick, Laverne Vercaigne, Donald E. Low, The Canadian Respiratory Infection Study Group, and Daryl J. Hoban Antimicrob. Agents Chemother. October 1999 43: 2504-2509; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trends in Antimicrobial Resistance among Clinical Isolates of the Bacteroides fragilis Group from 1992 to 1997 in Montreal, Canada Annie-Claude Labbé, Anne-Marie Bourgault, Jean Vincelette, Pierre L. Turgeon, and François Lamothe Antimicrob. Agents Chemother. October 1999 43: 2517-2519; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility Patterns of Enterococci Causing Infections in Europe M. A. Schouten, A. Voss, J. A. A. Hoogkamp-Korstanje, and The European VRE Study Group Antimicrob. Agents Chemother. October 1999 43: 2542-2546; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potentiation of Artemisinin Activity against Chloroquine-Resistant Plasmodium falciparum Strains by Using Heme Models Françoise Benoit-Vical, Anne Robert, and Bernard Meunier Antimicrob. Agents Chemother. October 1999 43: 2555-2558; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phenotypic Distinction in Enterococcus faecium and Enterococcus faecalis Strains between Susceptibility and Resistance to Growth-Enhancing Antibiotics Patrick Butaye, Luc A. Devriese, and Freddy Haesebrouck Antimicrob. Agents Chemother. October 1999 43: 2569-2570; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Mycoplasma hominis to Six Fluoroquinolones as Determined by E Test Ken B. Waites, Kay C. Canupp, and George E. Kenny Antimicrob. Agents Chemother. October 1999 43: 2571-2573; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii Mahmoud H. el Kouni, Vincenzo Guarcello, Omar N. Al Safarjalani, and Fardos N. M. Naguib Antimicrob. Agents Chemother. October 1999 43: 2437-2443; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Decreased Azithromycin Susceptibility of Neisseria gonorrhoeae Due to mtrR Mutations Leticia Zarantonelli, Graciela Borthagaray, Eun-Hee Lee, and William M. Shafer Antimicrob. Agents Chemother. October 1999 43: 2468-2472; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potent Bacteriolytic Activity of Ritipenem Associated with a Characteristic Profile of Affinities for Penicillin-Binding Proteins of Haemophilus influenzae Takashi Inui, Tadahiro Oshida, Toshio Endo, and Tadahiro Matsushita Antimicrob. Agents Chemother. October 1999 43: 2534-2537; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activity and Postantibiotic Effect of Levofloxacin against Anaerobes Susan L. Pendland, Mariela Diaz-Linares, Kevin W. Garey, Jennifer G. Woodward, Seonyoung Ryu, and Larry H. Danziger Antimicrob. Agents Chemother. October 1999 43: 2547-2549; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic Effects of Gatifloxacin against Gram-Positive and -Negative Organisms G. A. Pankuch, M. R. Jacobs, and P. C. Appelbaum Antimicrob. Agents Chemother. October 1999 43: 2574-2575; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Analysis of the blatoho Gene Coding for Toho-2--Lactamase R. Labia; and Yoshikazu Ishii Antimicrob. Agents Chemother. October 1999 43: 2576-2577; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.