Contents: November 1999, Volume 43, Issue 11        Mechanisms of Resistance        Pharmacology        Experimental Therapeutics        Clinical Therapeutics        Susceptibility        Antiviral Agents        Biologic Response Modifiers        Mechanisms of Action        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Mechanisms of Resistance:

---

Activities of Fluoroquinolones against Streptococcus pneumoniae Type II Topoisomerases Purified as Recombinant Proteins Ian Morrissey and John George Antimicrob. Agents Chemother. November 1999 43: 2579-2585; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Involvement of an Active Efflux System in the Natural Resistance of Pseudomonas aeruginosa to Aminoglycosides Julio Ramos Aires, Thilo Köhler, Hiroshi Nikaido, and Patrick Plésiat Antimicrob. Agents Chemother. November 1999 43: 2624-2628; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Isolation of Polymyxin B-Susceptible Mutants of Burkholderia pseudomallei and Molecular Characterization of Genetic Loci Involved in Polymyxin B Resistance Mary N. Burtnick and Donald E. Woods Antimicrob. Agents Chemother. November 1999 43: 2648-2656; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Insertion of Mini-IS605 and Deletion of Adjacent Sequences in the Nitroreductase (rdxA) Gene Cause Metronidazole Resistance in Helicobacter pylori NCTC11637 Yvette J. Debets-Ossenkopp, Raymond G. J. Pot, David J. van Westerloo, Avery Goodwin, Christina M. J. E. Vandenbroucke-Grauls, Douglas E. Berg, Paul S. Hoffman, and Johannes G. Kusters Antimicrob. Agents Chemother. November 1999 43: 2657-2662; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Accumulation of 3-Ketosteroids Induced by Itraconazole in Azole-Resistant Clinical Candida albicans Isolates Patrick Marichal, Jos Gorrens, Leen Laurijssens, Karen Vermuyten, Carl Van Hove, Ludo Le Jeune, Peter Verhasselt, Dominique Sanglard, Marcel Borgers, Frans C. S. Ramaekers, Frank Odds, and Hugo Vanden Bossche Antimicrob. Agents Chemother. November 1999 43: 2663-2670; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diversity of TEM Mutants in Proteus mirabilis R. Bonnet, C. De Champs, D. Sirot, C. Chanal, R. Labia, and J. Sirot Antimicrob. Agents Chemother. November 1999 43: 2671-2677; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Genes Encoding Resistance to Streptogramins A and B on the Activity of Quinupristin-Dalfopristin against Enterococcus faecium Bülent Bozdogan and Roland Leclercq Antimicrob. Agents Chemother. November 1999 43: 2720-2725; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Analysis of Azole Resistance by Transposon Mutagenesis in Saccharomyces cerevisiae D. P. Kontoyiannis Antimicrob. Agents Chemother. November 1999 43: 2731-2735; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence and Dissemination of Quinolone-Resistant Escherichia coli in the Community Javier Garau, Mariona Xercavins, Mónica Rodríguez-Carballeira, Josep Ramón Gómez-Vera, Ignacio Coll, Dolors Vidal, Teresa Llovet, and Ana Ruíz-Bremón Antimicrob. Agents Chemother. November 1999 43: 2736-2741; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The ATP Binding Cassette Transporter Gene CgCDR1 from Candida glabrata Is Involved in the Resistance of Clinical Isolates to Azole Antifungal Agents Dominique Sanglard, Françoise Ischer, David Calabrese, Paul A. Majcherczyk, and Jacques Bille Antimicrob. Agents Chemother. November 1999 43: 2753-2765; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of Insertion Sequence-Like Element IS1272 and Its Position Relative to Methicillin Resistance Genes in Clinically Important Staphylococci Nobumichi Kobayashi, Shozo Urasawa, Nobuyuki Uehara, and Naoki Watanabe Antimicrob. Agents Chemother. November 1999 43: 2780-2782; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Overexpression of Erg11p by the Regulatable GAL1 Promoter Confers Fluconazole Resistance in Saccharomyces cerevisiae Dimitrios P. Kontoyiannis, Namita Sagar, and Kendal D. Hirschi Antimicrob. Agents Chemother. November 1999 43: 2798-2800; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of the cfiA Gene among Bacteroides fragilis Strains in Japan and Relatedness of cfiA to Imipenem Resistance Kikuo Yamazoe, Naoki Kato, Haru Kato, Kaori Tanaka, Yoshihiro Katagiri, and Kunitomo Watanabe Antimicrob. Agents Chemother. November 1999 43: 2808-2810; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of F171 Mutations in the 6'-N-Acetyltransferase Type Ib [AAC(6')-Ib] Enzyme on Susceptibility to Aminoglycosides Ramona Chavideh, Steven Sholly, Doina Panaite, and Marcelo E. Tolmasky Antimicrob. Agents Chemother. November 1999 43: 2811-2812; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of rpoB Mutations Conferring Cross-Resistance to Rifamycins on Methicillin-Resistant Staphylococcus aureus Thomas A. Wichelhaus, Volker Schäfer, Volker Brade, and Boris Böddinghaus Antimicrob. Agents Chemother. November 1999 43: 2813-2816; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

Pharmacokinetics of Dapsone Administered Daily and Weekly in Human Immunodeficiency Virus-Infected Children Mark Mirochnick, Ellen Cooper, Ken McIntosh, Jing Xu, Jane Lindsey, David Jacobus, Lynne Mofenson, John L. Sullivan, Wayne Dankner, Lisa M. Frenkel, Sharon Nachman, Diane W. Wara, Daniel Johnson, Vincent R. Bonagura, Mobeen H. Rathore, Coleen K. Cunningham, and James McNamara Antimicrob. Agents Chemother. November 1999 43: 2586-2591; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Decreased Antipyrine Clearance following Endotoxin Administration: In Vivo Evidence of the Role of Nitric Oxide Kiyoyuki Kitaichi, Li Wang, Kenji Takagi, Mitsunori Iwase, Eiji Shibata, Masayuki Nadai, Kenzo Takagi, and Takaaki Hasegawa Antimicrob. Agents Chemother. November 1999 43: 2697-2701; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms of Fluoroquinolone Transport by Human Neutrophils John D. Walters, Fanjie Zhang, and Robin J. Nakkula Antimicrob. Agents Chemother. November 1999 43: 2710-2715; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of a Once-Daily Oral Dose of Moxifloxacin (Bay 12-8039), a New Enantiomerically Pure 8-Methoxy Quinolone John T. Sullivan, Marilyn Woodruff, John Lettieri, Vipin Agarwal, George J. Krol, Philip T. Leese, Susan Watson, and Allen H. Heller Antimicrob. Agents Chemother. November 1999 43: 2793-2797; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Experimental Therapeutics:

---

Dose Range Evaluation of Liposomal Nystatin and Comparisons with Amphotericin B and Amphotericin B Lipid Complex in Temporarily Neutropenic Mice Infected with an Isolate of Aspergillus fumigatus with Reduced Susceptibility to Amphotericin B David W. Denning and Peter Warn Antimicrob. Agents Chemother. November 1999 43: 2592-2599; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Levofloxacin for Experimental Aortic-Valve Endocarditis in Rabbits Infected with Viridans Group Streptococcus or Staphylococcus aureus Henry F. Chambers, Qing Xiang, Liu, Lucian Liuxin Chow, and Corinne Hackbarth Antimicrob. Agents Chemother. November 1999 43: 2742-2746; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Azithromycin Activities against Orientia tsutsugamushi Strains Isolated in Cases of Scrub Typhus in Northern Thailand George Watt, Pacharee Kantipong, Krisada Jongsakul, Pochaman Watcharapichat, and Duangporn Phulsuksombati Antimicrob. Agents Chemother. November 1999 43: 2817-2818; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Clinical Therapeutics:

---

Drug Tolerance in Mycobacterium tuberculosis Robert S. Wallis, Shripad Patil, Seon-Hee Cheon, Kay Edmonds, Manijeh Phillips, Mark D. Perkins, Moses Joloba, Alice Namale, John L. Johnson, Lucileia Teixeira, Reynaldo Dietze, Salman Siddiqi, Roy D. Mugerwa, Kathleen Eisenach, and Jerrold J. Ellner Antimicrob. Agents Chemother. November 1999 43: 2600-2606; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

Antimicrobial Susceptibilities and Serogroups of Clinical Strains of Clostridium difficile Isolated in France in 1991 and 1997 Frédéric Barbut, Dominique Decré, Béatrice Burghoffer, Danièle Lesage, Françoise Delisle, Valérie Lalande, Michel Delmée, Véronique Avesani, Nassita Sano, Cyril Coudert, and Jean-Claude Petit Antimicrob. Agents Chemother. November 1999 43: 2607-2611; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Survey of Susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Isolates to 26 Antimicrobial Agents: a Prospective U.S. Study C. Thornsberry, P. T. Ogilvie, H. P. Holley, Jr., and D. F. Sahm Antimicrob. Agents Chemother. November 1999 43: 2612-2623; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic Fungistatic Effects of Lactoferrin in Combination with Antifungal Drugs against Clinical Candida Isolates M. E. Kuipers, H. G. de Vries, M. C. Eikelboom, D. K. F. Meijer, and P. J. Swart Antimicrob. Agents Chemother. November 1999 43: 2635-2641; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Gemifloxacin (SB 265805, LB20304) Compared to Those of Other Oral Antimicrobial Agents against Unusual Anaerobes Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Kerin Tyrrell, and Yumi Warren Antimicrob. Agents Chemother. November 1999 43: 2726-2730; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility Testing of Helicobacter pylori in a Large Multicenter Trial: the MACH 2 Study Francis Mégraud, Norbert Lehn, Tore Lind, Ekkehard Bayerdörffer, Colm O'Morain, Robin Spiller, Peter Unge, Sander Veldhuyzen van Zanten, Michael Wrangstadh, and Carl Fredrik Burman Antimicrob. Agents Chemother. November 1999 43: 2747-2752; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Burkholderia mallei in Comparison to Those of Other Pathogenic Burkholderia spp. D. J. Kenny, P. Russell, D. Rogers, S. M. Eley, and R. W. Titball Antimicrob. Agents Chemother. November 1999 43: 2773-2775; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergy Testing of Vancomycin-Resistant Enterococcus faecium against Quinupristin-Dalfopristin in Combination with Other Antimicrobial Agents S. O. Matsumura, L. Louie, M. Louie, and A. E. Simor Antimicrob. Agents Chemother. November 1999 43: 2776-2779; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Gatifloxacin, Two Other Quinolones, and Five Nonquinolone Antimicrobials against Obligately Anaerobic Bacteria Reiner Schaumann, Grit Ackermann, Baerbel Pless, Marina C. Claros, and Arne C. Rodloff Antimicrob. Agents Chemother. November 1999 43: 2783-2786; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Neisseria gonorrhoeae to Fatty Acids and Monoglycerides Gudmundur Bergsson, Ólafur Steingrímsson, and Halldor Thormar Antimicrob. Agents Chemother. November 1999 43: 2790-2792; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Telithromycin (HMR 3647, RU 66647) Compared to Those of Erythromycin, Azithromycin, Clarithromycin, Roxithromycin, and Other Antimicrobial Agents against Unusual Anaerobes Ellie J. C. Goldstein, Diane M. Citron, C. Vreni Merriam, Yumi Warren, and Kerin Tyrrell Antimicrob. Agents Chemother. November 1999 43: 2801-2805; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Gemifloxacin (SB 265805, LB20304) against Recent Clinical Isolates of Chlamydia pneumoniae Patricia M. Roblin, Tamara Reznik, Andrei Kutlin, and Margaret R. Hammerschlag Antimicrob. Agents Chemother. November 1999 43: 2806-2807; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

Kinetics of Antiviral Activity and Intracellular Pharmacokinetics of Human Immunodeficiency Virus Type 1 Protease Inhibitors in Tissue Culture Michelina Nascimbeni, Claire Lamotte, Gilles Peytavin, Robert Farinotti, and François Clavel Antimicrob. Agents Chemother. November 1999 43: 2629-2634; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemoprophylaxis of Influenza A Virus Infections, with Single Doses of Zanamivir, Demonstrates that Zanamivir Is Cleared Slowly from the Respiratory Tract Robert J. Fenton, Peter J. Morley, Ian J. Owens, David Gower, Simon Parry, Lee Crossman, and Tony Wong Antimicrob. Agents Chemother. November 1999 43: 2642-2647; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Civamide (cis-Capsaicin) for Treatment of Primary or Recurrent Experimental Genital Herpes N. Bourne, D. I. Bernstein, and L. R. Stanberry Antimicrob. Agents Chemother. November 1999 43: 2685-2688; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oligonucleotides Tethered to a Short Polyguanylic Acid Stretch Are Targeted to Macrophages: Enhanced Antiviral Activity of a Vesicular Stomatitis Virus-Specific Antisense Oligonucleotide Vikram Prasad, Shehla Hashim, Amitabha Mukhopadhyay, Sandip K. Basu, and Rajendra P. Roy Antimicrob. Agents Chemother. November 1999 43: 2689-2696; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Performance Liquid Chromatographic Determination of Ribavirin in Whole Blood To Assess Disposition in Erythrocytes Masato Homma, Anura L. Jayewardene, John Gambertoglio, and Francesca Aweeka Antimicrob. Agents Chemother. November 1999 43: 2716-2719; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Biologic Response Modifiers:

---

Erythromycin Inhibits Transcriptional Activation of NF-B, but not NFAT, through Calcineurin-Independent Signaling in T Cells Yosuke Aoki and Peter N. Kao Antimicrob. Agents Chemother. November 1999 43: 2678-2684; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

Competition of Various -Lactam Antibiotics for the Major Penicillin-Binding Proteins of Helicobacter pylori: Antibacterial Activity and Effects on Bacterial Morphology Cindy R. DeLoney and Neal L. Schiller Antimicrob. Agents Chemother. November 1999 43: 2702-2709; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Specific Inhibition of the Eubacterial DNA Ligase by Arylamino Compounds Giovanni Ciarrocchi, Donald G. MacPhee, Les W. Deady, and Leann Tilley Antimicrob. Agents Chemother. November 1999 43: 2766-2772; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Modulatory Effects of Clarithromycin on the Production of Cytokines by a Tumor Kazuhiko Sassa, Yutaka Mizushima, and Masashi Kobayashi Antimicrob. Agents Chemother. November 1999 43: 2787-2789; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Letters:

---

Silver-Containing Polymers Jörg Michael Schierholz, Joseph Beuth, Gerhard Pulverer, Dietmar-Pierre König;, Ronald S. Scharlack;, Günter Kampf, Beate Dietze, Constanze Wendt, Heike Martiny, and Christian Große-Siestrup Antimicrob. Agents Chemother. November 1999 43: 2819-2821; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.