Contents: December 1999, Volume 43, Issue 12        Minireviews        Experimental Therapeutics        Pharmacology        Antiviral Agents        Susceptibility        Clinical Therapeutics        Mechanisms of Action        Mechanisms of Resistance        Biologic Response Modifiers        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Minireviews:

---

Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants Marilyn C. Roberts, Joyce Sutcliffe, Patrice Courvalin, Lars Bogo Jensen, Julian Rood, and Helena Seppala Antimicrob. Agents Chemother. December 1999 43: 2823-2830; [Full Text] [PDF] [Reprints and Permissions]

---

Experimental Therapeutics:

---

Efficacies of High-Dose Fluconazole plus Amphotericin B and High-Dose Fluconazole plus 5-Fluorocytosine versus Amphotericin B, Fluconazole, and 5-Fluorocytosine Monotherapies in Treatment of Experimental Endocarditis, Endophthalmitis, and Pyelonephritis Due to Candida albicans Arnold Louie, Weiguo Liu, Dorothy A. Miller, Alana C. Sucke, Qing-Feng Liu, George L. Drusano, Martin Mayers, and Michael H. Miller Antimicrob. Agents Chemother. December 1999 43: 2831-2840; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interaction between Fluconazole and Amphotericin B in Mice with Systemic Infection Due to Fluconazole-Susceptible or -Resistant Strains of Candida albicans Arnold Louie, Partha Banerjee, George L. Drusano, Mehdi Shayegani, and Michael H. Miller Antimicrob. Agents Chemother. December 1999 43: 2841-2847; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of the Oxazolidinones Linezolid and Eperezolid in Experimental Intra-Abdominal Abscess Due to Enterococcus faecalis or Vancomycin-Resistant Enterococcus faecium T. Schülin, C. Thauvin-Eliopoulos, R. C. Moellering, Jr., and G. M. Eliopoulos Antimicrob. Agents Chemother. December 1999 43: 2873-2876; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Poloxamer CRL-1072 against Mycobacterium avium in Macrophage Culture and in Mice Chinnaswamy Jagannath, Martin R. Emanuele, and Robert L. Hunter Antimicrob. Agents Chemother. December 1999 43: 2898-2903; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of the Triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in Experimental Murine Cutaneous and Visceral Leishmaniases Hail M. Al-Abdely, John R. Graybill, David Loebenberg, and Peter C. Melby Antimicrob. Agents Chemother. December 1999 43: 2910-2914; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Dose Isoniazid Therapy for Isoniazid-Resistant Murine Mycobacterium tuberculosis Infection M. H. Cynamon, Y. Zhang, T. Harpster, S. Cheng, and M. S. DeStefano Antimicrob. Agents Chemother. December 1999 43: 2922-2924; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Beneficial Effect of Adjunctive Azithromycin in Treatment of Mucoid Pseudomonas aeruginosa Pneumonia in the Murine Model David P. Nicolau, Mary Anne Banevicius, Charles H. Nightingale, and Richard Quintiliani Antimicrob. Agents Chemother. December 1999 43: 3033-3035; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

Pharmacokinetics of Cefepime in Patients with Thermal Burn Injury Charles R. Bonapace, Roger L. White, Lawrence V. Friedrich, E. Douglas Norcross, and John A. Bosso Antimicrob. Agents Chemother. December 1999 43: 2848-2854; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potentiation of Vancomycin-Induced Histamine Release by Muscle Relaxants and Morphine in Rats Hideki Shuto, Masanori Sueyasu, Shuji Otsuki, Tomoko Hara, Yuki Tsuruta, Yasufumi Kataoka, and Ryozo Oishi Antimicrob. Agents Chemother. December 1999 43: 2881-2884; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Proteoglycan and Collagen Biochemical Variations during Fluoroquinolone-Induced Chondrotoxicity in Mice Marie-Agnès Simonin, Pascale Gegout-Pottie, Alain Minn, Pierre Gillet, Patrick Netter, and Bernard Terlain Antimicrob. Agents Chemother. December 1999 43: 2915-2921; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Determination of Zidovudine Triphosphate Intracellular Concentrations in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Individuals by Tandem Mass Spectrometry Eva Font, Osvaldo Rosario, Jorge Santana, Hermes García, Jean-Pierre Sommadossi, and Jose F. Rodriguez Antimicrob. Agents Chemother. December 1999 43: 2964-2968; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Oral Bioavailability and Pharmacokinetics of Trovafloxacin in Patients with AIDS Melinda K. Lacy, David P. Nicolau, Charles H. Nightingale, Amy Geffken, Renli Teng, John Vincent, and Richard Quintiliani Antimicrob. Agents Chemother. December 1999 43: 3005-3007; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

Pharmacokinetics of [14C]Abacavir, a Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitor, Administered in a Single Oral Dose to HIV-1-Infected Adults: a Mass Balance Study James A. McDowell, Gregory E. Chittick, Joshua R. Ravitch, Ronald E. Polk, Thomas M. Kerkering, and Daniel S. Stein Antimicrob. Agents Chemother. December 1999 43: 2855-2861; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hydroxyurea Potentiates the Antiherpesvirus Activities of Purine and Pyrimidine Nucleoside and Nucleoside Phosphonate Analogs J. Neyts and E. De Clercq Antimicrob. Agents Chemother. December 1999 43: 2885-2892; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1 Jeffrey W. Corbett, Soo S. Ko, James D. Rodgers, Susan Jeffrey, Lee T. Bacheler, Ronald M. Klabe, Sharon Diamond, Chii-Ming Lai, Shelley R. Rabel, Jo Anne Saye, Stephen P. Adams, George L. Trainor, Paul S. Anderson, and Susan K. Erickson-Viitanen Antimicrob. Agents Chemother. December 1999 43: 2893-2897; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Population Pharmacokinetics of Lamivudine in Adult Human Immunodeficiency Virus-Infected Patients Enrolled in Two Phase III Clinical Trials Katy H. P. Moore, Geoffrey J. Yuen, Elizabeth K. Hussey, Gary E. Pakes, Joseph J. Eron, Jr., and John A. Bartlett Antimicrob. Agents Chemother. December 1999 43: 3025-3029; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells Maurizio Del Poeta, Shih-Fong Chen, Daniel Von Hoff, Christine C. Dykstra, Mansukh C. Wani, Govindarajan Manikumar, Joseph Heitman, Monroe E. Wall, and John R. Perfect Antimicrob. Agents Chemother. December 1999 43: 2862-2868; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Tobramycin and Six Other Antibiotics against Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis Ribhi M. Shawar, David L. MacLeod, Richard L. Garber, Jane L. Burns, Jenny R. Stapp, Carla R. Clausen, and S. K. Tanaka Antimicrob. Agents Chemother. December 1999 43: 2877-2880; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New Method for Assessing Metronidazole Susceptibility of Giardia lamblia Trophozoites M. Céu Sousa and J. Poiares-da-Silva Antimicrob. Agents Chemother. December 1999 43: 2939-2942; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of a Nitrofurazone-Containing Urinary Catheter and a Silver Hydrogel Catheter against Multidrug-Resistant Bacteria Characteristic of Catheter-Associated Urinary Tract Infection James R. Johnson, Parissa Delavari, and Miguel Azar Antimicrob. Agents Chemother. December 1999 43: 2990-2995; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of SCH27899 Alone and in Combination with 17 Other Antimicrobial Agents Peter C. Fuchs, Arthur L. Barry, and Steven D. Brown Antimicrob. Agents Chemother. December 1999 43: 2996-2997; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Antimicrobial Activities of the Newly Synthesized Quinolone HSR-903, Sitafloxacin (DU-6859a), Gatifloxacin (AM-1155), and Levofloxacin against Mycobacterium tuberculosis and Mycobacterium avium Complex Haruaki Tomioka, Katsumasa Sato, Tatsuya Akaki, Hiroko Kajitani, Shin Kawahara, and Mitsunori Sakatani Antimicrob. Agents Chemother. December 1999 43: 3001-3004; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Resistance of Diarrheagenic Escherichia coli Isolated from Children under the Age of 5 Years from Ifakara, Tanzania Jordi Vila, Martha Vargas, Climent Casals, Honorato Urassa, Hassan Mshinda, David Schellemberg, and Joaquim Gascon Antimicrob. Agents Chemother. December 1999 43: 3022-3024; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Bacteriostatic and Bactericidal Activities of Cefodizime against Borrelia burgdorferi Sensu Lato Rossella Murgia, Federico Marchetti, and Marina Cinco Antimicrob. Agents Chemother. December 1999 43: 3030-3032; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Ketolide HMR3647, Macrolides, and Other Antibiotics against Lactobacillus, Leuconostoc, and Pediococcus Isolates M. Zarazaga, Y. Sáenz, A. Portillo, C. Tenorio, F. Ruiz-Larrea, R. Del Campo, F. Baquero, and C. Torres Antimicrob. Agents Chemother. December 1999 43: 3039-3041; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Clinical Therapeutics:

---

Azithromycin as Treatment for Disseminated Mycobacterium avium Complex in AIDS Patients Susan L. Koletar, Alison J. Berry, Michael H. Cynamon, Jeffrey Jacobson, Judith S. Currier, Rob Roy MacGregor, Michael W. Dunne, and Debra J. Williams Antimicrob. Agents Chemother. December 1999 43: 2869-2872; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

Biochemical Characterization of Novel Tetrahydrofuranyl 1-Methylcarbapenems: Stability to Hydrolysis by Renal Dehydropeptidases and Bacterial -Lactamases, Binding to Penicillin Binding Proteins, and Permeability Properties Youjun Yang, Raymond T. Testa, Niraja Bhachech, Beth A. Rasmussen, and Karen Bush Antimicrob. Agents Chemother. December 1999 43: 2904-2909; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Proton-Pumping-ATPase-Targeted Antifungal Activity of a Novel Conjugated Styryl Ketone Elias K. Manavathu, Jonathan R. Dimmock, Sarvesh C. Vashishtha, and Pranatharthi H. Chandrasekar Antimicrob. Agents Chemother. December 1999 43: 2950-2959; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of a Mycobacterium smegmatis Mutant Lacking Penicillin Binding Protein 1 Helen Billman-Jacobe, Ruth E. Haites, and Ross L. Coppel Antimicrob. Agents Chemother. December 1999 43: 3011-3013; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Resistance:

---

Incidence and Characterization of Integrons, Genetic Elements Mediating Multiple-Drug Resistance, in Avian Escherichia coli Lydia Bass, Cynthia A. Liebert, Margie D. Lee, Anne O. Summers, David G. White, Stephan G. Thayer, and John J. Maurer Antimicrob. Agents Chemother. December 1999 43: 2925-2929; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multilocus Genotypes and DNA Fingerprints Do Not Predict Variation in Azole Resistance among Clinical Isolates of Candida albicans Leah E. Cowen, Caroline Sirjusingh, Richard C. Summerbell, Sharon Walmsley, Susan Richardson, Linda M. Kohn, and James B. Anderson Antimicrob. Agents Chemother. December 1999 43: 2930-2938; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The pfmdr1 Gene Is Associated with a Multidrug-Resistant Phenotype in Plasmodium falciparum from the Western Border of Thailand R. N. Price, C. Cassar, A. Brockman, M. Duraisingh, M. van Vugt, N. J. White, F. Nosten, and S. Krishna Antimicrob. Agents Chemother. December 1999 43: 2943-2949; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Automated Thermal Cycling Is Superior to Traditional Methods for Nucleotide Sequencing of blaSHV Genes Patricia A. Bradford Antimicrob. Agents Chemother. December 1999 43: 2960-2963; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Gatifloxacin Activity against Quinolone-Resistant Gyrase: Allele-Specific Enhancement of Bacteriostatic and Bactericidal Activities by the C-8-Methoxy Group Tao Lu, Xilin Zhao, and Karl Drlica Antimicrob. Agents Chemother. December 1999 43: 2969-2974; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of a Pseudomonas aeruginosa Efflux Pump Contributing to Aminoglycoside Impermeability Shannon Westbrock-Wadman, David R. Sherman, Mark J. Hickey, Silvija N. Coulter, Ya Qi Zhu, Paul Warrener, Lisa Y. Nguyen, Ribhi M. Shawar, Kim R. Folger, and C. Kendall Stover Antimicrob. Agents Chemother. December 1999 43: 2975-2983; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Gemifloxacin against Penicillin- and Ciprofloxacin-Resistant Streptococcus pneumoniae Displaying Topoisomerase- and Efflux-Mediated Resistance Mechanisms Victoria J. Heaton, Colin E. Goldsmith, Jane E. Ambler, and L. Mark Fisher Antimicrob. Agents Chemother. December 1999 43: 2998-3000; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Level Aminoglycoside Resistance in the Beta-Hemolytic Group G Streptococcus Isolate BM2721 Marc Galimand, Thierry Lambert, Guy Gerbaud, and Patrice Courvalin Antimicrob. Agents Chemother. December 1999 43: 3008-3010; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution of -Lactamases in Actinomycetes Hiroshi Ogawara, Nao Kawamura, Takuji Kudo, Ken-Ichiro Suzuki, and Takashi Nakase Antimicrob. Agents Chemother. December 1999 43: 3014-3017; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Characterization of Antimicrobial Resistance in Canadian Isolates of Salmonella Serovar Typhimurium DT104 Lai-King Ng, Michael R. Mulvey, Irene Martin, Geoffrey A. Peters, and Wendy Johnson Antimicrob. Agents Chemother. December 1999 43: 3018-3021; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Novel Streptomycin and Spectinomycin Resistance Gene as a Gene Cassette within a Class 1 Integron Isolated from Escherichia coli Dorthe Sandvang Antimicrob. Agents Chemother. December 1999 43: 3036-3038; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Biologic Response Modifiers:

---

Antibiotic-Induced Cell Wall Fragments of Staphylococcus aureus Increase Endothelial Chemokine Secretion and Adhesiveness for Granulocytes P. van Langevelde, E. Ravensbergen, P. Grashoff, H. Beekhuizen, P. H. P. Groeneveld, and J. T. van Dissel Antimicrob. Agents Chemother. December 1999 43: 2984-2989; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Letters:

---

Increase in Resistance of Methicillin-Resistant Staphylococcus aureus to -Lactams Caused by Mutations Conferring Resistance to Benzalkonium Chloride, a Disinfectant Widely Used in Hospitals Nobuyoshi Akimitsu, Hiroshi Hamamoto, Ryu-ichi Inoue, Mikio Shoji, Akifumi Akamine, Koh-ichi Takemori, Naotaka Hamasaki, and Kazuhisa Sekimizu Antimicrob. Agents Chemother. December 1999 43: 3042-3043; [Full Text] [PDF] [Reprints and Permissions]

Influence of a Pulmonary Surfactant on the In Vitro Activity of Tobramycin against Pseudomonas aeruginosa Edgar J. Caldwell and Donald S. Piper Antimicrob. Agents Chemother. December 1999 43: 3044 [Full Text] [PDF] [Reprints and Permissions]

Effect of Garlic on Vancomycin-Resistant Enterococci Daisy Jonkers, Judith Sluimer, and Ellen Stobberingh Antimicrob. Agents Chemother. December 1999 43: 3045 [Full Text] [PDF] [Reprints and Permissions]

---

Errata:

---

Pharmacokinetics of Oral Zidovudine Entrapped in Biodegradable Nanospheres in Rabbits Diana P. Callender, Nalina Jayaprakash, Aaron Bell, Vidmantas Petraitis, Ruta PetraItiene, Myrna Candelario, Robert Schaufele, James M. Dunn, Shizuko Sei, Thomas J. Walsh, and Frank M. Balis Antimicrob. Agents Chemother. December 1999 43: 3046 [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Ketolides HRM 3647 and HRM 3004, Levofloxacin, and Other Quinolones and Macrolides against Neisseria spp. and Moraxella catarrhalis J. A. Sáez-Nieto and J. A. Vázquez Antimicrob. Agents Chemother. December 1999 43: 3046 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.