Contents: April 1999, Volume 43, Issue 4        Minireviews        Susceptibility        Antiviral Agents        Biologic Response Modifiers        Mechanisms of Action        Mechanisms of Resistance        Experimental Therapeutics        Pharmacology        Recent Approvals        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Aminoglycosides: Activity and Resistance Marie-Paule Mingeot-Leclercq, Youri Glupczynski, and Paul M. Tulkens Antimicrob. Agents Chemother. April 1999 43: 727-737; [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro and In Vivo Antibacterial Activities of a Novel Glycylcycline, the 9-t-Butylglycylamido Derivative of Minocycline (GAR-936) P. J. Petersen, N. V. Jacobus, W. J. Weiss, P. E. Sum, and R. T. Testa Antimicrob. Agents Chemother. April 1999 43: 738-744; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antibacterial Properties of Pexiganan, an Analog of Magainin Yigong Ge, Dorothy L. MacDonald, Kenneth J. Holroyd, Clyde Thornsberry, Hannah Wexler, and Michael Zasloff Antimicrob. Agents Chemother. April 1999 43: 782-788; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ampicillin-Sulbactam and Amoxicillin-Clavulanate Susceptibility Testing of Escherichia coli Isolates with Different -Lactam Resistance Phenotypes Antonio Oliver, María Pérez-Vázquez, Manuel Martínez-Ferrer, Fernando Baquero, Luis de Rafael, and Rafael Cantón Antimicrob. Agents Chemother. April 1999 43: 862-867; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Two Ketolides, HMR 3647 and HMR 3004, against Gram-Positive Bacteria Kumthorn Malathum, Teresa M. Coque, Kavindra V. Singh, and Barbara E. Murray Antimicrob. Agents Chemother. April 1999 43: 930-936; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Activities of Broad-Spectrum -Lactam Compounds against 1,128 Gram-Positive Cocci Recently Isolated in Cancer Treatment Centers Daniel J. Diekema, Stacy L. Coffman, Steven A. Marshall, Mondell L. Beach, Kenneth V. I. Rolston, and Ronald N. Jones Antimicrob. Agents Chemother. April 1999 43: 940-943; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of 13 Fluoroquinolones against Staphylococcus aureus Isolates with Characterized Mutations in gyrA, gyrB, grlA, and norA and against Wild-Type Isolates J. L. Muñoz Bellido, M. A. Alonso Manzanares, G. Yagüe Guirao, M. N. Gutiérrez Zufiaurre, M. C. M. Toldos, M. Segovia Hernández, and J. A. García-Rodríguez Antimicrob. Agents Chemother. April 1999 43: 966-968; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Ketolides HRM 3647 and HRM 3004, Levofloxacin, and Other Quinolones and Macrolides against Neisseria spp. and Moraxella catarrhalis J. A. Sáez-Nieto and J. A. Vázquez Antimicrob. Agents Chemother. April 1999 43: 983-984; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Bile Salts: Natural Detergents for the Prevention of Sexually Transmitted Diseases Betsy C. Herold, Risa Kirkpatrick, Daniel Marcellino, Anna Travelstead, Valentina Pilipenko, Holly Krasa, James Bremer, Li Jin Dong, and Morris D. Cooper Antimicrob. Agents Chemother. April 1999 43: 745-751; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of RD3-0028 Aerosol Treatment against Respiratory Syncytial Virus Infection in Immunosuppressed Mice Kenji Sudo, Wataru Watanabe, Kenji Konno, Ryu Sato, Tsuyoshi Kajiyashiki, Shiro Shigeta, and Tomoyuki Yokota Antimicrob. Agents Chemother. April 1999 43: 752-757; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) Therapy Prolongs Survival of Infant Macaques Inoculated with Simian Immunodeficiency Virus with Reduced Susceptibility to PMPA Koen K. A. van Rompay, Julie M. Cherrington, Marta L. Marthas, Patrick D. Lamy, Peter J. Dailey, Don R. Canfield, Ross P. Tarara, Norbert Bischofberger, and Niels C. Pedersen Antimicrob. Agents Chemother. April 1999 43: 802-812; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiviral Effect of Hyperthermic Treatment in Rhinovirus Infection C. Conti, A. de Marco, P. Mastromarino, P. Tomao, and M. G. Santoro Antimicrob. Agents Chemother. April 1999 43: 822-829; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Immune Response Modifier Imiquimod Requires STAT-1 for induction of Interferon, Interferon-Stimulated Genes, and Interleukin-6 Renata L. A. Bottrel, Yi-Li Yang, David E. Levy, Mark Tomai, and Luiz F. L. Reis Antimicrob. Agents Chemother. April 1999 43: 856-861; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of 3-Hydroxyphthaloyl--Lactoglobulin on Vaginal Transmission of Simian Immunodeficiency Virus in Rhesus Monkeys Michael S. Wyand, Kelledy H. Manson, Christopher J. Miller, and A. Robert Neurath Antimicrob. Agents Chemother. April 1999 43: 978-980; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Recombinant Bactericidal/Permeability-Increasing Protein (rBPI21) in Combination with Sulfadiazine Is Active against Toxoplasma gondii Anis A. Khan, Lewis H. Lambert, Jr., Jack S. Remington, and Fausto G. Araujo Antimicrob. Agents Chemother. April 1999 43: 758-762; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Fourteen-Member Macrolides Inhibit Interleukin-8 Release by Human Eosinophils from Atopic Donors Tadashi Kohyama, Hajime Takizawa, Shin Kawasaki, Norihisa Akiyama, Makoto Sato, and Koji Ito Antimicrob. Agents Chemother. April 1999 43: 907-911; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Potentiation of Isoniazid Activity against Mycobacterium tuberculosis by Melatonin Ian Wiid, Eileen Hoal-van Helden, Dinie Hon, Carl Lombard, and Paul van Helden Antimicrob. Agents Chemother. April 1999 43: 975-977; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Effects of Azole Antifungal Drugs on the Transition from Yeast Cells to Hyphae in Susceptible and Resistant Isolates of the Pathogenic Yeast Candida albicans Kien C. Ha and Theodore C. White Antimicrob. Agents Chemother. April 1999 43: 763-768; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nitrite Reductase from Pseudomonas aeruginosa Released by Antimicrobial Agents and Complement Induces Interleukin-8 Production in Bronchial Epithelial Cells Borann Sar, Kazunori Oishi, Akihiro Wada, Toshiya Hirayama, Kouji Matsushima, and Tsuyoshi Nagatake Antimicrob. Agents Chemother. April 1999 43: 794-801; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

LY303366 Exhibits Rapid and Potent Fungicidal Activity in Flow Cytometric Assays of Yeast Viability Lisa J. Green, Philip Marder, Larry L. Mann, Li-Chun Chio, and William L. Current Antimicrob. Agents Chemother. April 1999 43: 830-835; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The Anti-Influenza Virus Drug Rimantadine Has Trypanocidal Activity John M. Kelly, Michael A. Miles, and Anita C. Skinner Antimicrob. Agents Chemother. April 1999 43: 985-987; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Cloning, Sequence Analyses, Expression, and Distribution of ampC-ampR from Morganella morganii Clinical Isolates Laurent Poirel, Michele Guibert, Delphine Girlich, Thierry Naas, and Patrice Nordmann Antimicrob. Agents Chemother. April 1999 43: 769-776; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Fosfomycin-Resistant Isolates of Shiga-Like Toxin-Producing Escherichia coli O26 Toshinobu Horii, Taku Kimura, Kumiko Sato, Keigo Shibayama, and Michio Ohta Antimicrob. Agents Chemother. April 1999 43: 789-793; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Frequency, In Vitro Reversible Switching of Candida lusitaniae Clinical Isolates from Amphotericin B Susceptibility to Resistance Stephanie A. Yoon, Jose A. Vazquez, Paul E. Steffan, Jack D. Sobel, and Robert A. Akins Antimicrob. Agents Chemother. April 1999 43: 836-845; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of an Antibiotic Resistance Gene Cluster of Salmonella typhimurium DT104 Connie E. Briggs and Pina M. Fratamico Antimicrob. Agents Chemother. April 1999 43: 846-849; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Strength and Regulation of the Different Promoters for Chromosomal -Lactamases of Klebsiella oxytoca Bénédicte Fournier, Annie Gravel, David C. Hooper, and Paul H. Roy Antimicrob. Agents Chemother. April 1999 43: 850-855; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Impact of gyrA and parC Mutations on Quinolone Resistance, Doubling Time, and Supercoiling Degree of Escherichia coli Simone Bagel, Volker Hüllen, Bernd Wiedemann, and Peter Heisig Antimicrob. Agents Chemother. April 1999 43: 868-875; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Structure of In31, a blaIMP-Containing Pseudomonas aeruginosa Integron Phyletically Related to In5, Which Carries an Unusual Array of Gene Cassettes Nezha Laraki, Moreno Galleni, Iris Thamm, Maria Letizia Riccio, Gianfranco Amicosante, Jean-Marie Frère, and Gian Maria Rossolini Antimicrob. Agents Chemother. April 1999 43: 890-901; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical Characterization of the Pseudomonas aeruginosa 101/1477 Metallo--Lactamase IMP-1 Produced by Escherichia coli Nezha Laraki, Nicola Franceschini, Gian Maria Rossolini, Pasqualino Santucci, Cécile Meunier, Edwin de Pauw, Gianfranco Amicosante, Jean Marie Frère, and Moreno Galleni Antimicrob. Agents Chemother. April 1999 43: 902-906; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New Resistance Gene, linB, Conferring Resistance to Lincosamides by Nucleotidylation in Enterococcus faecium HM1025 Bülent Bozdogan, Latifa Berrezouga, Ming-Shang Kuo, David A. Yurek, Kathleen A. Farley, Brian J. Stockman, and Roland Leclercq Antimicrob. Agents Chemother. April 1999 43: 925-929; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of Resistance during Antimicrobial Therapy Caused by Insertion Sequence Interruption of Porin Genes Santiago Hernández-Allés, Vicente J. Benedí, Luis Martínez-Martínez, Álvaro Pascual, Alicia Aguilar, Juan M. Tomás, and Sebastián Albertí Antimicrob. Agents Chemother. April 1999 43: 937-939; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Presence of mefA and mefE Genes in Streptococcus agalactiae C. Arpin, H. Daube, F. Tessier, and C. Quentin Antimicrob. Agents Chemother. April 1999 43: 944-946; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Alterations in GyrA and ParC Associated with Fluoroquinolone Resistance in Enterococcus faecium Nagwa el Amin, Shah Jalal, and Bengt Wretlind Antimicrob. Agents Chemother. April 1999 43: 947-949; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutations in the gyrA, parC, and parE Genes Associated with Fluoroquinolone Resistance in Clinical Isolates of Mycoplasma hominis Cécile M. Bebear, Joel Renaudin, Alain Charron, Hélène Renaudin, Bertille de Barbeyrac, Thierry Schaeverbeke, and Christiane Bebear Antimicrob. Agents Chemother. April 1999 43: 954-956; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Basis of AmpC Hyperproduction in Clinical Isolates of Escherichia coli E. C. Nelson and B. Gay Elisha Antimicrob. Agents Chemother. April 1999 43: 957-959; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron-Mediated Rifampin Resistance in Pseudomonas aeruginosa Chanwit Tribuddharat and Michael Fennewald Antimicrob. Agents Chemother. April 1999 43: 960-962; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequences of the Genes for the TEM-20, TEM-21, TEM-22, and TEM-29 Extended-Spectrum -Lactamases Guillaume Arlet, Sylvie Goussard, Patrice Courvalin, and Alain Philippon Antimicrob. Agents Chemother. April 1999 43: 969-971; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pseudomonas aeruginosa: a Survey of Resistance in 136 Hospitals in Spain E. Bouza, F. Garcia-Garrote, E. Cercenado, M. Marin, and M. S. Diaz Antimicrob. Agents Chemother. April 1999 43: 981-982; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibition of the Emergence of Ciprofloxacin Resistance in Streptococcus pneumoniae by the Multidrug Efflux Inhibitor Reserpine Penelope N. Markham Antimicrob. Agents Chemother. April 1999 43: 988-989; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Growth in the Presence of Salicylate Increases Fluoroquinolone Resistance in Staphylococcus aureus John E. Gustafson, Pierre V. Candelaria, Scott A. Fisher, Jodie P. Goodridge, Tanya M. Lichocik, Tracy M. McWilliams, Christopher T. D. Price, Frances G. O'Brien, and Warren B. Grubb Antimicrob. Agents Chemother. April 1999 43: 990-992; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Exposure to Metronidazole In Vivo Readily Induces Resistance in Helicobacter pylori and Reduces the Efficacy of Eradication Therapy in Mice Peter J. Jenks, Agnes Labigne, and Richard L. Ferrero Antimicrob. Agents Chemother. April 1999 43: 777-781; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Doxycycline, Azithromycin, or Trovafloxacin for Treatment of Experimental Rocky Mountain Spotted Fever in Dogs E. B. Breitschwerdt, M. G. Papich, B. C. Hegarty, B. Gilger, S. I. Hancock, and M. G. Davidson Antimicrob. Agents Chemother. April 1999 43: 813-821; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Clavulanate Induces Expression of the Pseudomonas aeruginosa AmpC Cephalosporinase at Physiologically Relevant Concentrations and Antagonizes the Antibacterial Activity of Ticarcillin Philip D. Lister, Victoria M. Gardner, and Christine C. Sanders Antimicrob. Agents Chemother. April 1999 43: 882-889; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lipopolyamines: Novel Antiendotoxin Compounds That Reduce Mortality in Experimental Sepsis Caused by Gram-Negative Bacteria Sunil A. David, Richard Silverstein, Claudia R. Amura, Tammy Kielian, and David C. Morrison Antimicrob. Agents Chemother. April 1999 43: 912-919; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Protection by Short-Chain Fatty Acids against 1--D-Arabinofuranosylcytosine-Induced Intestinal Lesions in Germfree Mice Mariana Gontijo Ramos, Eduardo Alves Bambirra, Jacques Robert Nicoli, Denise Carmona Cara, Enio Cardillo Vieira, and Jacqueline Alvarez-Leite Antimicrob. Agents Chemother. April 1999 43: 950-953; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trovafloxacin in Combination with Vancomycin against Penicillin-Resistant Pneumococci in the Rabbit Meningitis Model Dina Rodoni, Fränzi Hänni, Cynthia M. Gerber, Marianne Cottagnoud, Klaus Neftel, Martin G. Täuber, and Philippe Cottagnoud Antimicrob. Agents Chemother. April 1999 43: 963-965; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacodynamics of Vancomycin for the Treatment of Experimental Penicillin- and Cephalosporin-Resistant Pneumococcal Meningitis Amina Ahmed, Hasan Jafri, Irja Lutsar, Cynthia C. McCoig, Monica Trujillo, Loretta Wubbel, Sharon Shelton, and George H. McCracken, Jr. Antimicrob. Agents Chemother. April 1999 43: 876-881; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of -L-2',3'-Dideoxy-5-Fluorocytidine in Rhesus Monkeys Lee T. Martin, Erika Cretton-Scott, Raymond F. Schinazi, Xiao-Jian Zhou, Harold M. McClure, Christophe Mathe, Gilles Gosselin, Jean-Louis Imbach, and Jean-Pierre Sommadossi Antimicrob. Agents Chemother. April 1999 43: 920-924; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Oral Zidovudine Entrapped in Biodegradable Nanospheres in Rabbits Diana P. Callender, Nalini Jayaprakash, Aaron Bell, Vidmantas Petraitis, Ruta Petratienes, Myrna Candelario, Robert Schaufele, James M. Dunn, Shizuko Sei, Thomas J. Walsh, and Frank M. Balis Antimicrob. Agents Chemother. April 1999 43: 972-974; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Recent Approvals:

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New Antimicrobial Agents Approved by the U.S. Food and Drug Administration in 1998 and New Indications for Previously Approved Agents Antimicrob. Agents Chemother. April 1999 43: 993-994; [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Disruption of vanS by IS1216V in a Clinical Isolate of Enterococcus faecium with VanA Glycopeptide Resistance Ana Lucia da Costa Darini, Marie-France I. Palepou, Dorothy James, and Neil Woodford Antimicrob. Agents Chemother. April 1999 43: 995-996; [Full Text] [PDF] [Reprints and Permissions]

Lack of Ritonavir Antifungal Effect In Vitro P. Diz, A. Ocampo, I. Iglesias, and I. Otero Antimicrob. Agents Chemother. April 1999 43: 997 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.