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Minireviews:

George A. Jacoby

History of Antimicrobial Agents and Chemotherapy from 1972 to 1998
Antimicrob. Agents Chemother. 1999 43: 999-1002. [Full Text] [PDF] [Reprints and Permissions]  

Marie-Paule Mingeot-Leclercq and Paul M. Tulkens

Aminoglycosides: Nephrotoxicity
Antimicrob. Agents Chemother. 1999 43: 1003-1012. [Full Text] [PDF] [Reprints and Permissions]  

Pharmacology:

Pier Carlo Braga, Maria Teresa Sala, and Monica dal Sasso

Pharmacodynamic Effects of Subinhibitory Concentrations of Rufloxacin on Bacterial Virulence Factors
Antimicrob. Agents Chemother. 1999 43: 1013-1019. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Silke Lober, Susanne Ziege, Margot Rau, Gabriele Schreiber, Alain Mignot, Peter Koeppe, and Hartmut Lode

Pharmacokinetics of Gatifloxacin and Interaction with an Antacid Containing Aluminum and Magnesium
Antimicrob. Agents Chemother. 1999 43: 1067-1071. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hideki Kita, Hirotami Matsuo, Hitomi Takanaga, Junichi Kawakami, Koujirou Yamamoto, Tatsuji Iga, Mikihiko Naito, Takashi Tsuruo, Atsushi Asanuma, Keiji Yanagisawa, and Yasufumi Sawada

In Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous System
Antimicrob. Agents Chemother. 1999 43: 1091-1097. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kevin W. Garey, Charles A. Peloquin, Paul G. Godo, Anne N. Nafziger, and Guy W. Amsden

Lack of Effect of Zafirlukast on the Pharmacokinetics of Azithromycin, Clarithromycin, and 14-Hydroxyclarithromycin in Healthy Volunteers
Antimicrob. Agents Chemother. 1999 43: 1152-1155. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

H. Cody Meissner, Jessie R. Groothuis, William J. Rodriguez, Robert C. Welliver, Geoff Hogg, Peter H. Gray, Richard Loh, Eric A. F. Simoes, Peter Sly, Ann K. Miller, Alice I. Nichols, Diane K. Jorkasky, Daniel E. Everitt, and Kathleen A. Thompson

Safety and Pharmacokinetics of an Intramuscular Monoclonal Antibody (SB 209763) against Respiratory Syncytial Virus (RSV) in Infants and Young Children at Risk for Severe RSV Disease
Antimicrob. Agents Chemother. 1999 43: 1183-1188. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Milap C. Nahata, Vijay I. Vashi, Robert N. Swanson, Michael A. Messig, and Menger Chung

Pharmacokinetics of Ampicillin and Sulbactam in Pediatric Patients
Antimicrob. Agents Chemother. 1999 43: 1225-1229. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anther C.-F. Keung, Robert C. Owens, Jr., Mark G. Eller, Scott J. Weir, David P. Nicolau, and Charles H. Nightingale

Pharmacokinetics of Rifapentine in Subjects Seropositive for the Human Immunodeficiency Virus: a Phase I Study
Antimicrob. Agents Chemother. 1999 43: 1230-1233. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Douglas N. Fish and Edward Abraham

Pharmacokinetics of a Clarithromycin Suspension Administered via Nasogastric Tube to Seriously Ill Patients
Antimicrob. Agents Chemother. 1999 43: 1277-1280. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Martin Brunner, Ursula Hollenstein, Simon Delacher, Dorothea Jäger, Rainer Schmid, Edith Lackner, Apostoulos Georgopoulos, Hans Georg Eichler, and Markus Müller

Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues
Antimicrob. Agents Chemother. 1999 43: 1307-1309. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Experimental Therapeutics:

Michel LeBrun, Louis Grenier, Pierrette Gourde, Michel G. Bergeron, Gaston Labrecque, and Denis Beauchamp

Effectiveness and Toxicity of Gentamicin in an Experimental Model of Pyelonephritis: Effect of the Time of Administration
Antimicrob. Agents Chemother. 1999 43: 1020-1026. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Masahiro Takahata, Junichi Mitsuyama, Yoshiko Yamashiro, Minoru Yonezawa, Harumi Araki, Yozo Todo, Shinzaburo Minami, Yasuo Watanabe, and Hirokazu Narita

In Vitro and In Vivo Antimicrobial Activities of T-3811ME, a Novel Des-F(6)-Quinolone
Antimicrob. Agents Chemother. 1999 43: 1077-1084. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Philip D. Lister and Christine C. Sanders

Pharmacodynamics of Trovafloxacin, Ofloxacin, and Ciprofloxacin against Streptococcus pneumoniae in an In Vitro Pharmacokinetic Model
Antimicrob. Agents Chemother. 1999 43: 1118-1123. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Debra C. Quenelle, Jay K. Staas, Gary A. Winchester, Esther L. W. Barrow, and William W. Barrow

Efficacy of Microencapsulated Rifampin in Mycobacterium tuberculosis-Infected Mice
Antimicrob. Agents Chemother. 1999 43: 1144-1151. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

M. H. Cynamon, S. P. Klemens, C. A. Sharpe, and S. Chase

Activities of Several Novel Oxazolidinones against Mycobacterium tuberculosis in a Murine Model
Antimicrob. Agents Chemother. 1999 43: 1189-1191. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Andrea M. Rediske, Beverly L. Roeder, Maren K. Brown, Jared L. Nelson, Rachel L. Robison, David O. Draper, G. Bruce Schaalje, Richard A. Robison, and William G. Pitt

Ultrasonic Enhancement of Antibiotic Action on Escherichia coli Biofilms: an In Vivo Model
Antimicrob. Agents Chemother. 1999 43: 1211-1214. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Youssef Ouadrhiri, Bernard Scorneaux, Yves Sibille, and Paul M. Tulkens

Mechanism of the Intracellular Killing and Modulation of Antibiotic Susceptibility of Listeria monocytogenes in THP-1 Macrophages Activated by Gamma Interferon
Antimicrob. Agents Chemother. 1999 43: 1242-1251. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

J. Guarro, I. Pujol, and E. Mayayo

In Vitro and In Vivo Experimental Activities of Antifungal Agents against Fusarium solani
Antimicrob. Agents Chemother. 1999 43: 1256-1257. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jason V. Brooks, Synthia K. Furney, and Ian M. Orme

Metronidazole Therapy in Mice Infected with Tuberculosis
Antimicrob. Agents Chemother. 1999 43: 1285-1288. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Biologic Response Modifiers:

Nancy S. Postma, Rob C. Hermsen, Daan J. A. Crommelin, Wijnand M. C. Eling, and Jan Zuidema

Thiolated Recombinant Human Tumor Necrosis Factor-Alpha Protects against Plasmodium berghei K173-Induced Experimental Cerebral Malaria in Mice
Antimicrob. Agents Chemother. 1999 43: 1027-1033. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Action:

Robert S. Liao, Robert P. Rennie, and James A. Talbot

Assessment of the Effect of Amphotericin B on the Vitality of Candida albicans
Antimicrob. Agents Chemother. 1999 43: 1034-1041. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Benjawan Phetsuksiri, Alain R. Baulard, Andrea M. Cooper, David E. Minnikin, James D. Douglas, Gurdyal S. Besra, and Patrick J. Brennan

Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis
Antimicrob. Agents Chemother. 1999 43: 1042-1051. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Katrin Ingold, Peter Bigler, Wolfgang Thormann, Tania Cavaliero, Bruno Gottstein, and Andrew Hemphill

Efficacies of Albendazole Sulfoxide and Albendazole Sulfone against In Vitro-Cultivated Echinococcus multilocularis Metacestodes
Antimicrob. Agents Chemother. 1999 43: 1052-1061. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yan-Qiong Xiong, Michael R. Yeaman, and Arnold S. Bayer

In Vitro Antibacterial Activities of Platelet Microbicidal Protein and Neutrophil Defensin against Staphylococcus aureus Are Influenced by Antibiotics Differing in Mechanism of Action
Antimicrob. Agents Chemother. 1999 43: 1111-1117. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Genshi Zhao, Timothy I. Meier, Steven D. Kahl, Kyle R. Gee, and Larry C. Blaszczak

BOCILLIN FL, a Sensitive and Commercially Available Reagent for Detection of Penicillin-Binding Proteins
Antimicrob. Agents Chemother. 1999 43: 1124-1128. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Eduardo Caio Torres-Santos, Davyson Lima Moreira, Maria Auxiliadora C. Kaplan, Maria Nazareth Meirelles, and Bartira Rossi-Bergmann

Selective Effect of 2',6'-Dihydroxy-4'-Methoxychalcone Isolated from Piper aduncum on Leishmania amazonensis
Antimicrob. Agents Chemother. 1999 43: 1234-1241. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hiroyuki Wakabayashi, Hiroshi Matsumoto, Koichi Hashimoto, Susumu Teraguchi, Mitsunori Takase, and Hirotoshi Hayasawa

N-Acylated and D Enantiomer Derivatives of a Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial Activity
Antimicrob. Agents Chemother. 1999 43: 1267-1269. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Manhong Wu and Robert E. W. Hancock

Improved Derivatives of Bactenecin, a Cyclic Dodecameric Antimicrobial Cationic Peptide
Antimicrob. Agents Chemother. 1999 43: 1274-1276. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David Balasundaram, Celia White Tabor, and Herbert Tabor

Sensitivity of Spermidine-Deficient Saccharomyces cerevisiae to Paromomycin
Antimicrob. Agents Chemother. 1999 43: 1314-1316. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Mechanisms of Resistance:

Gerard Lina, Alain Quaglia, Marie-Elisabeth Reverdy, Roland Leclercq, François Vandenesch, and Jerome Etienne

Distribution of Genes Encoding Resistance to Macrolides, Lincosamides, and Streptogramins among Staphylococci
Antimicrob. Agents Chemother. 1999 43: 1062-1066. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Martina M. Ochs, Matthew P. McCusker, Manjeet Bains, and Robert E. W. Hancock

Negative Regulation of the Pseudomonas aeruginosa Outer Membrane Porin OprD Selective for Imipenem and Basic Amino Acids
Antimicrob. Agents Chemother. 1999 43: 1085-1090. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laurent Poirel, Michele Guibert, Samuel Bellais, Thierry Naas, and Patrice Nordmann

Integron- and Carbenicillinase-Mediated Reduced Susceptibility to Amoxicillin-Clavulanic Acid in Isolates of Multidrug-Resistant Salmonella enterica Serotype Typhimurium DT104 from French Patients
Antimicrob. Agents Chemother. 1999 43: 1098-1104. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kristin Hegstad Dahl, Gunnar Skov Simonsen, Ørjan Olsvik, and Arnfinn Sundsfjord

Heterogeneity in the vanB Gene Cluster of Genomically Diverse Clinical Strains of Vancomycin-Resistant Enterococci
Antimicrob. Agents Chemother. 1999 43: 1105-1110. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Xiao-Su Pan and L. Mark Fisher

Streptococcus pneumoniae DNA Gyrase and Topoisomerase IV: Overexpression, Purification, and Differential Inhibition by Fluoroquinolones
Antimicrob. Agents Chemother. 1999 43: 1129-1136. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Beatriz Robredo, Kavindra V. Singh, Fernando Baquero, Barbara E. Murray, and Carmen Torres

From vanA Enterococcus hirae to vanA Enterococcus faecium: a Study of Feed Supplementation with Avoparcin and Tylosin in Young Chickens
Antimicrob. Agents Chemother. 1999 43: 1137-1143. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jun Okuda, Eriko Hayakawa, Mitsuaki Nishibuchi, and Takeshi Nishino

Sequence Analysis of the gyrA and parC Homologues of a Wild-Type Strain of Vibrio parahaemolyticus and Its Fluoroquinolone-Resistant Mutants
Antimicrob. Agents Chemother. 1999 43: 1156-1162. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kentaro Asai, Noboru Tsuchimori, Kenji Okonogi, John R. Perfect, Osamu Gotoh, and Yuzo Yoshida

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450
Antimicrob. Agents Chemother. 1999 43: 1163-1169. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Todd A. Davies, Glenn A. Pankuch, Bonifacio E. Dewasse, Michael R. Jacobs, and Peter C. Appelbaum

In Vitro Development of Resistance to Five Quinolones and Amoxicillin-Clavulanate in Streptococcus pneumoniae
Antimicrob. Agents Chemother. 1999 43: 1177-1182. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Paul D. Stapleton, Kevin P. Shannon, and Gary L. French

Carbapenem Resistance in Escherichia coli Associated with Plasmid-Determined CMY-4 -Lactamase Production and Loss of an Outer Membrane Protein
Antimicrob. Agents Chemother. 1999 43: 1206-1210. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yasuko Asahi, Yasuo Takeuchi, and Kimiko Ubukata

Diversity of Substitutions within or Adjacent to Conserved Amino Acid Motifs of Penicillin-Binding Protein 2X in Cephalosporin-Resistant Streptococcus pneumoniae Isolates
Antimicrob. Agents Chemother. 1999 43: 1252-1255. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Thierry Naas, Laurence Philippon, Laurent Poirel, Esthel Ronco, and Patrice Nordmann

An SHV-Derived Extended-Spectrum -Lactamase in Pseudomonas aeruginosa
Antimicrob. Agents Chemother. 1999 43: 1281-1284. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Shang Wei Wu, Kathrine Dornbusch, and Göran Kronvall

Genetic Characterization of Resistance to Extended-Spectrum -Lactams in Klebsiella oxytoca Isolates Recovered from Patients with Septicemia at Hospitals in the Stockholm Area
Antimicrob. Agents Chemother. 1999 43: 1294-1297. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Taiji Nakae, Akira Nakajima, Toshihisa Ono, Kohjiro Saito, and Hiroshi Yoneyama

Resistance to -Lactam Antibiotics in Pseudomonas aeruginosa Due to Interplay between the MexAB-OprM Efflux Pump and -Lactamase
Antimicrob. Agents Chemother. 1999 43: 1301-1303. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Susceptibility:

Junko K. Akada, Mutsunori Shirai, Kenji Fujii, Kiwamu Okita, and Teruko Nakazawa

In Vitro Anti-Helicobacter pylori Activities of New Rifamycin Derivatives, KRM-1648 and KRM-1657
Antimicrob. Agents Chemother. 1999 43: 1072-1076. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Joyce Kohler, Karen L. Dorso, Katherine Young, Gail G. Hammond, Hugh Rosen, Helmut Kropp, and Lynn L. Silver

In Vitro Activities of the Potent, Broad-Spectrum Carbapenem MK-0826 (L-749,345) against Broad-Spectrum -Lactamase-and Extended-Spectrum -Lactamase-Producing Klebsiella pneumoniae and Escherichia coli Clinical Isolates
Antimicrob. Agents Chemother. 1999 43: 1170-1176. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Josep M. Torres-Rodríguez, Raúl Mendez, Olga López-Jodra, Yolanda Morera, Mateu Espasa, Teresa Jimenez, and Carme Lagunas

In Vitro Susceptibilities of Clinical Yeast Isolates to the New Antifungal Eberconazole Compared with Their Susceptibilities to Clotrimazole and Ketoconazole
Antimicrob. Agents Chemother. 1999 43: 1258-1259. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Elizabeth M. Johnson, Adrien Szekely, and David W. Warnock

In Vitro Activity of Syn-2869, a Novel Triazole Agent, against Emerging and Less Common Mold Pathogens
Antimicrob. Agents Chemother. 1999 43: 1260-1263. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Karen L. Oakley, Caroline B. Moore, and David W. Denning

Comparison of In Vitro Activity of Liposomal Nystatin against Aspergillus Species with Those of Nystatin, Amphotericin B (AB) Deoxycholate, AB Colloidal Dispersion, Liposomal AB, AB Lipid Complex, and Itraconazole
Antimicrob. Agents Chemother. 1999 43: 1264-1266. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

E. Könönen, A. Kanervo, K. Salminen, and H. Jousimies-Somer

-Lactamase Production and Antimicrobial Susceptibility of Oral Heterogeneous Fusobacterium nucleatum Populations in Young Children
Antimicrob. Agents Chemother. 1999 43: 1270-1273. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Cornelius J. Clancy and M. Hong Nguyen

Correlation between In Vitro Susceptibility Determined by E Test and Response to Therapy with Amphotericin B: Results from a Multicenter Prospective Study of Candidemia
Antimicrob. Agents Chemother. 1999 43: 1289-1290. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Kimberly L. Bergman, Keith M. Olsen, Tom E. Peddicord, Paul D. Fey, and Mark E. Rupp

Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates of Haemophilus influenzae and Streptococcus pneumoniae
Antimicrob. Agents Chemother. 1999 43: 1291-1293. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Murat Akova, Deniz Gür, David M. Livermore, Tanil Kocagöz, and H. Erdal Akalin

In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs
Antimicrob. Agents Chemother. 1999 43: 1298-1300. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

T. Skinner-Adams and T. M. E. Davis

Synergistic In Vitro Antimalarial Activity of Omeprazole and Quinine
Antimicrob. Agents Chemother. 1999 43: 1304-1306. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pak-Leung Ho, Tak-Lun Que, Dominic Ngai-Chong Tsang, Tak-Keung Ng, Kin-Hung Chow, and Wing-Hon Seto

Emergence of Fluoroquinolone Resistance among Multiply Resistant Strains of Streptococcus pneumoniae in Hong Kong
Antimicrob. Agents Chemother. 1999 43: 1310-1313. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Antiviral Agents:

Hillard M. Lazarus, Robert Belanger, Anna Candoni, Mickaël Aoun, Regina Jurewicz, Lynn Marks, and The Penciclovir Immunocompromised Study Group

Intravenous Penciclovir for Treatment of Herpes Simplex Infections in Immunocompromised Patients: Results of a Multicenter, Acyclovir-Controlled Trial
Antimicrob. Agents Chemother. 1999 43: 1192-1197. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

J. A. Johnson and J. D. Gangemi

Selective Inhibition of Human Papillomavirus-Induced Cell Proliferation by (S)-1-[3-Hydroxy-2-(Phosphonylmethoxy)propyl]cytosine
Antimicrob. Agents Chemother. 1999 43: 1198-1205. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Chemistry; Biosynthesis:

Roy H. Mosher, Ashish S. Paradkar, Cecilia Anders, Barry Barton, and Susan E. Jensen

Genes Specific for the Biosynthesis of Clavam Metabolites Antipodal to Clavulanic Acid Are Clustered with the Gene for Clavaminate Synthase 1 in Streptomyces clavuligerus
Antimicrob. Agents Chemother. 1999 43: 1215-1224. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.