Contents: May 1999, Volume 43, Issue 5        Minireviews        Pharmacology        Experimental Therapeutics        Biologic Response Modifiers        Mechanisms of Action        Mechanisms of Resistance        Susceptibility        Antiviral Agents        Chemistry; Biosynthesis Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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History of Antimicrobial Agents and Chemotherapy from 1972 to 1998 George A. Jacoby Antimicrob. Agents Chemother. May 1999 43: 999-1002; [Full Text] [PDF] [Reprints and Permissions]

Aminoglycosides: Nephrotoxicity Marie-Paule Mingeot-Leclercq and Paul M. Tulkens Antimicrob. Agents Chemother. May 1999 43: 1003-1012; [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Pharmacodynamic Effects of Subinhibitory Concentrations of Rufloxacin on Bacterial Virulence Factors Pier Carlo Braga, Maria Teresa Sala, and Monica dal Sasso Antimicrob. Agents Chemother. May 1999 43: 1013-1019; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Gatifloxacin and Interaction with an Antacid Containing Aluminum and Magnesium Silke Lober, Susanne Ziege, Margot Rau, Gabriele Schreiber, Alain Mignot, Peter Koeppe, and Hartmut Lode Antimicrob. Agents Chemother. May 1999 43: 1067-1071; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous System Hideki Kita, Hirotami Matsuo, Hitomi Takanaga, Junichi Kawakami, Koujirou Yamamoto, Tatsuji Iga, Mikihiko Naito, Takashi Tsuruo, Atsushi Asanuma, Keiji Yanagisawa, and Yasufumi Sawada Antimicrob. Agents Chemother. May 1999 43: 1091-1097; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lack of Effect of Zafirlukast on the Pharmacokinetics of Azithromycin, Clarithromycin, and 14-Hydroxyclarithromycin in Healthy Volunteers Kevin W. Garey, Charles A. Peloquin, Paul G. Godo, Anne N. Nafziger, and Guy W. Amsden Antimicrob. Agents Chemother. May 1999 43: 1152-1155; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety and Pharmacokinetics of an Intramuscular Monoclonal Antibody (SB 209763) against Respiratory Syncytial Virus (RSV) in Infants and Young Children at Risk for Severe RSV Disease H. Cody Meissner, Jessie R. Groothuis, William J. Rodriguez, Robert C. Welliver, Geoff Hogg, Peter H. Gray, Richard Loh, Eric A. F. Simoes, Peter Sly, Ann K. Miller, Alice I. Nichols, Diane K. Jorkasky, Daniel E. Everitt, and Kathleen A. Thompson Antimicrob. Agents Chemother. May 1999 43: 1183-1188; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Ampicillin and Sulbactam in Pediatric Patients Milap C. Nahata, Vijay I. Vashi, Robert N. Swanson, Michael A. Messig, and Menger Chung Antimicrob. Agents Chemother. May 1999 43: 1225-1229; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Rifapentine in Subjects Seropositive for the Human Immunodeficiency Virus: a Phase I Study Anther C.-F. Keung, Robert C. Owens, Jr., Mark G. Eller, Scott J. Weir, David P. Nicolau, and Charles H. Nightingale Antimicrob. Agents Chemother. May 1999 43: 1230-1233; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of a Clarithromycin Suspension Administered via Nasogastric Tube to Seriously Ill Patients Douglas N. Fish and Edward Abraham Antimicrob. Agents Chemother. May 1999 43: 1277-1280; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Distribution and Antimicrobial Activity of Ciprofloxacin in Human Soft Tissues Martin Brunner, Ursula Hollenstein, Simon Delacher, Dorothea Jäger, Rainer Schmid, Edith Lackner, Apostoulos Georgopoulos, Hans Georg Eichler, and Markus Müller Antimicrob. Agents Chemother. May 1999 43: 1307-1309; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Effectiveness and Toxicity of Gentamicin in an Experimental Model of Pyelonephritis: Effect of the Time of Administration Michel LeBrun, Louis Grenier, Pierrette Gourde, Michel G. Bergeron, Gaston Labrecque, and Denis Beauchamp Antimicrob. Agents Chemother. May 1999 43: 1020-1026; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Antimicrobial Activities of T-3811ME, a Novel Des-F(6)-Quinolone Masahiro Takahata, Junichi Mitsuyama, Yoshiko Yamashiro, Minoru Yonezawa, Harumi Araki, Yozo Todo, Shinzaburo Minami, Yasuo Watanabe, and Hirokazu Narita Antimicrob. Agents Chemother. May 1999 43: 1077-1084; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacodynamics of Trovafloxacin, Ofloxacin, and Ciprofloxacin against Streptococcus pneumoniae in an In Vitro Pharmacokinetic Model Philip D. Lister and Christine C. Sanders Antimicrob. Agents Chemother. May 1999 43: 1118-1123; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Microencapsulated Rifampin in Mycobacterium tuberculosis-Infected Mice Debra C. Quenelle, Jay K. Staas, Gary A. Winchester, Esther L. W. Barrow, and William W. Barrow Antimicrob. Agents Chemother. May 1999 43: 1144-1151; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Several Novel Oxazolidinones against Mycobacterium tuberculosis in a Murine Model M. H. Cynamon, S. P. Klemens, C. A. Sharpe, and S. Chase Antimicrob. Agents Chemother. May 1999 43: 1189-1191; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ultrasonic Enhancement of Antibiotic Action on Escherichia coli Biofilms: an In Vivo Model Andrea M. Rediske, Beverly L. Roeder, Maren K. Brown, Jared L. Nelson, Rachel L. Robison, David O. Draper, G. Bruce Schaalje, Richard A. Robison, and William G. Pitt Antimicrob. Agents Chemother. May 1999 43: 1211-1214; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of the Intracellular Killing and Modulation of Antibiotic Susceptibility of Listeria monocytogenes in THP-1 Macrophages Activated by Gamma Interferon Youssef Ouadrhiri, Bernard Scorneaux, Yves Sibille, and Paul M. Tulkens Antimicrob. Agents Chemother. May 1999 43: 1242-1251; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Experimental Activities of Antifungal Agents against Fusarium solani J. Guarro, I. Pujol, and E. Mayayo Antimicrob. Agents Chemother. May 1999 43: 1256-1257; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Metronidazole Therapy in Mice Infected with Tuberculosis Jason V. Brooks, Synthia K. Furney, and Ian M. Orme Antimicrob. Agents Chemother. May 1999 43: 1285-1288; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Thiolated Recombinant Human Tumor Necrosis Factor-Alpha Protects against Plasmodium berghei K173-Induced Experimental Cerebral Malaria in Mice Nancy S. Postma, Rob C. Hermsen, Daan J. A. Crommelin, Wijnand M. C. Eling, and Jan Zuidema Antimicrob. Agents Chemother. May 1999 43: 1027-1033; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Assessment of the Effect of Amphotericin B on the Vitality of Candida albicans Robert S. Liao, Robert P. Rennie, and James A. Talbot Antimicrob. Agents Chemother. May 1999 43: 1034-1041; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimycobacterial Activities of Isoxyl and New Derivatives through the Inhibition of Mycolic Acid Synthesis Benjawan Phetsuksiri, Alain R. Baulard, Andrea M. Cooper, David E. Minnikin, James D. Douglas, Gurdyal S. Besra, and Patrick J. Brennan Antimicrob. Agents Chemother. May 1999 43: 1042-1051; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacies of Albendazole Sulfoxide and Albendazole Sulfone against In Vitro-Cultivated Echinococcus multilocularis Metacestodes Katrin Ingold, Peter Bigler, Wolfgang Thormann, Tania Cavaliero, Bruno Gottstein, and Andrew Hemphill Antimicrob. Agents Chemother. May 1999 43: 1052-1061; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antibacterial Activities of Platelet Microbicidal Protein and Neutrophil Defensin against Staphylococcus aureus Are Influenced by Antibiotics Differing in Mechanism of Action Yan-Qiong Xiong, Michael R. Yeaman, and Arnold S. Bayer Antimicrob. Agents Chemother. May 1999 43: 1111-1117; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

BOCILLIN FL, a Sensitive and Commercially Available Reagent for Detection of Penicillin-Binding Proteins Genshi Zhao, Timothy I. Meier, Steven D. Kahl, Kyle R. Gee, and Larry C. Blaszczak Antimicrob. Agents Chemother. May 1999 43: 1124-1128; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selective Effect of 2',6'-Dihydroxy-4'-Methoxychalcone Isolated from Piper aduncum on Leishmania amazonensis Eduardo Caio Torres-Santos, Davyson Lima Moreira, Maria Auxiliadora C. Kaplan, Maria Nazareth Meirelles, and Bartira Rossi-Bergmann Antimicrob. Agents Chemother. May 1999 43: 1234-1241; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

N-Acylated and D Enantiomer Derivatives of a Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial Activity Hiroyuki Wakabayashi, Hiroshi Matsumoto, Koichi Hashimoto, Susumu Teraguchi, Mitsunori Takase, and Hirotoshi Hayasawa Antimicrob. Agents Chemother. May 1999 43: 1267-1269; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Improved Derivatives of Bactenecin, a Cyclic Dodecameric Antimicrobial Cationic Peptide Manhong Wu and Robert E. W. Hancock Antimicrob. Agents Chemother. May 1999 43: 1274-1276; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sensitivity of Spermidine-Deficient Saccharomyces cerevisiae to Paromomycin David Balasundaram, Celia White Tabor, and Herbert Tabor Antimicrob. Agents Chemother. May 1999 43: 1314-1316; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Distribution of Genes Encoding Resistance to Macrolides, Lincosamides, and Streptogramins among Staphylococci Gerard Lina, Alain Quaglia, Marie-Elisabeth Reverdy, Roland Leclercq, François Vandenesch, and Jerome Etienne Antimicrob. Agents Chemother. May 1999 43: 1062-1066; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Negative Regulation of the Pseudomonas aeruginosa Outer Membrane Porin OprD Selective for Imipenem and Basic Amino Acids Martina M. Ochs, Matthew P. McCusker, Manjeet Bains, and Robert E. W. Hancock Antimicrob. Agents Chemother. May 1999 43: 1085-1090; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Integron- and Carbenicillinase-Mediated Reduced Susceptibility to Amoxicillin-Clavulanic Acid in Isolates of Multidrug-Resistant Salmonella enterica Serotype Typhimurium DT104 from French Patients Laurent Poirel, Michele Guibert, Samuel Bellais, Thierry Naas, and Patrice Nordmann Antimicrob. Agents Chemother. May 1999 43: 1098-1104; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Heterogeneity in the vanB Gene Cluster of Genomically Diverse Clinical Strains of Vancomycin-Resistant Enterococci Kristin Hegstad Dahl, Gunnar Skov Simonsen, Ørjan Olsvik, and Arnfinn Sundsfjord Antimicrob. Agents Chemother. May 1999 43: 1105-1110; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Streptococcus pneumoniae DNA Gyrase and Topoisomerase IV: Overexpression, Purification, and Differential Inhibition by Fluoroquinolones Xiao-Su Pan and L. Mark Fisher Antimicrob. Agents Chemother. May 1999 43: 1129-1136; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

From vanA Enterococcus hirae to vanA Enterococcus faecium: a Study of Feed Supplementation with Avoparcin and Tylosin in Young Chickens Beatriz Robredo, Kavindra V. Singh, Fernando Baquero, Barbara E. Murray, and Carmen Torres Antimicrob. Agents Chemother. May 1999 43: 1137-1143; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequence Analysis of the gyrA and parC Homologues of a Wild-Type Strain of Vibrio parahaemolyticus and Its Fluoroquinolone-Resistant Mutants Jun Okuda, Eriko Hayakawa, Mitsuaki Nishibuchi, and Takeshi Nishino Antimicrob. Agents Chemother. May 1999 43: 1156-1162; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450 Kentaro Asai, Noboru Tsuchimori, Kenji Okonogi, John R. Perfect, Osamu Gotoh, and Yuzo Yoshida Antimicrob. Agents Chemother. May 1999 43: 1163-1169; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Development of Resistance to Five Quinolones and Amoxicillin-Clavulanate in Streptococcus pneumoniae Todd A. Davies, Glenn A. Pankuch, Bonifacio E. Dewasse, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. May 1999 43: 1177-1182; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Carbapenem Resistance in Escherichia coli Associated with Plasmid-Determined CMY-4 -Lactamase Production and Loss of an Outer Membrane Protein Paul D. Stapleton, Kevin P. Shannon, and Gary L. French Antimicrob. Agents Chemother. May 1999 43: 1206-1210; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Diversity of Substitutions within or Adjacent to Conserved Amino Acid Motifs of Penicillin-Binding Protein 2X in Cephalosporin-Resistant Streptococcus pneumoniae Isolates Yasuko Asahi, Yasuo Takeuchi, and Kimiko Ubukata Antimicrob. Agents Chemother. May 1999 43: 1252-1255; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

An SHV-Derived Extended-Spectrum -Lactamase in Pseudomonas aeruginosa Thierry Naas, Laurence Philippon, Laurent Poirel, Esthel Ronco, and Patrice Nordmann Antimicrob. Agents Chemother. May 1999 43: 1281-1284; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genetic Characterization of Resistance to Extended-Spectrum -Lactams in Klebsiella oxytoca Isolates Recovered from Patients with Septicemia at Hospitals in the Stockholm Area Shang Wei Wu, Kathrine Dornbusch, and Göran Kronvall Antimicrob. Agents Chemother. May 1999 43: 1294-1297; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Resistance to -Lactam Antibiotics in Pseudomonas aeruginosa Due to Interplay between the MexAB-OprM Efflux Pump and -Lactamase Taiji Nakae, Akira Nakajima, Toshihisa Ono, Kohjiro Saito, and Hiroshi Yoneyama Antimicrob. Agents Chemother. May 1999 43: 1301-1303; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro Anti-Helicobacter pylori Activities of New Rifamycin Derivatives, KRM-1648 and KRM-1657 Junko K. Akada, Mutsunori Shirai, Kenji Fujii, Kiwamu Okita, and Teruko Nakazawa Antimicrob. Agents Chemother. May 1999 43: 1072-1076; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the Potent, Broad-Spectrum Carbapenem MK-0826 (L-749,345) against Broad-Spectrum -Lactamase-and Extended-Spectrum -Lactamase-Producing Klebsiella pneumoniae and Escherichia coli Clinical Isolates Joyce Kohler, Karen L. Dorso, Katherine Young, Gail G. Hammond, Hugh Rosen, Helmut Kropp, and Lynn L. Silver Antimicrob. Agents Chemother. May 1999 43: 1170-1176; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Clinical Yeast Isolates to the New Antifungal Eberconazole Compared with Their Susceptibilities to Clotrimazole and Ketoconazole Josep M. Torres-Rodríguez, Raúl Mendez, Olga López-Jodra, Yolanda Morera, Mateu Espasa, Teresa Jimenez, and Carme Lagunas Antimicrob. Agents Chemother. May 1999 43: 1258-1259; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Syn-2869, a Novel Triazole Agent, against Emerging and Less Common Mold Pathogens Elizabeth M. Johnson, Adrien Szekely, and David W. Warnock Antimicrob. Agents Chemother. May 1999 43: 1260-1263; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of In Vitro Activity of Liposomal Nystatin against Aspergillus Species with Those of Nystatin, Amphotericin B (AB) Deoxycholate, AB Colloidal Dispersion, Liposomal AB, AB Lipid Complex, and Itraconazole Karen L. Oakley, Caroline B. Moore, and David W. Denning Antimicrob. Agents Chemother. May 1999 43: 1264-1266; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

-Lactamase Production and Antimicrobial Susceptibility of Oral Heterogeneous Fusobacterium nucleatum Populations in Young Children E. Könönen, A. Kanervo, K. Salminen, and H. Jousimies-Somer Antimicrob. Agents Chemother. May 1999 43: 1270-1273; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Correlation between In Vitro Susceptibility Determined by E Test and Response to Therapy with Amphotericin B: Results from a Multicenter Prospective Study of Candidemia Cornelius J. Clancy and M. Hong Nguyen Antimicrob. Agents Chemother. May 1999 43: 1289-1290; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Activities and Postantibiotic Effects of Clarithromycin, 14-Hydroxy-Clarithromycin, and Azithromycin in Epithelial Cell Lining Fluid against Clinical Isolates of Haemophilus influenzae and Streptococcus pneumoniae Kimberly L. Bergman, Keith M. Olsen, Tom E. Peddicord, Paul D. Fey, and Mark E. Rupp Antimicrob. Agents Chemother. May 1999 43: 1291-1293; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs Murat Akova, Deniz Gür, David M. Livermore, Tanil Kocagöz, and H. Erdal Akalin Antimicrob. Agents Chemother. May 1999 43: 1298-1300; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Synergistic In Vitro Antimalarial Activity of Omeprazole and Quinine T. Skinner-Adams and T. M. E. Davis Antimicrob. Agents Chemother. May 1999 43: 1304-1306; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Fluoroquinolone Resistance among Multiply Resistant Strains of Streptococcus pneumoniae in Hong Kong Pak-Leung Ho, Tak-Lun Que, Dominic Ngai-Chong Tsang, Tak-Keung Ng, Kin-Hung Chow, and Wing-Hon Seto Antimicrob. Agents Chemother. May 1999 43: 1310-1313; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Intravenous Penciclovir for Treatment of Herpes Simplex Infections in Immunocompromised Patients: Results of a Multicenter, Acyclovir-Controlled Trial Hillard M. Lazarus, Robert Belanger, Anna Candoni, Mickaël Aoun, Regina Jurewicz, Lynn Marks, and The Penciclovir Immunocompromised Study Group Antimicrob. Agents Chemother. May 1999 43: 1192-1197; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Selective Inhibition of Human Papillomavirus-Induced Cell Proliferation by (S)-1-[3-Hydroxy-2-(Phosphonylmethoxy)propyl]cytosine J. A. Johnson and J. D. Gangemi Antimicrob. Agents Chemother. May 1999 43: 1198-1205; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Chemistry; Biosynthesis:

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Genes Specific for the Biosynthesis of Clavam Metabolites Antipodal to Clavulanic Acid Are Clustered with the Gene for Clavaminate Synthase 1 in Streptomyces clavuligerus Roy H. Mosher, Ashish S. Paradkar, Cecilia Anders, Barry Barton, and Susan E. Jensen Antimicrob. Agents Chemother. May 1999 43: 1215-1224; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.