Contents: July 1999, Volume 43, Issue 7        Minireviews        Susceptibility        Pharmacology        Chemistry; Biosynthesis        Mechanisms of Action        Mechanisms of Resistance        Antiviral Agents        Experimental Therapeutics        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

---

Minireviews:

---

Why Metronidazole Is Active against both Bacteria and Parasites John Samuelson Antimicrob. Agents Chemother. July 1999 43: 1533-1541; [Full Text] [PDF] [Reprints and Permissions]

---

Susceptibility:

---

Salt-Resistant Alpha-Helical Cationic Antimicrobial Peptides Carol Friedrich, Monisha G. Scott, Nedra Karunaratne, Hong Yan, and Robert E. W. Hancock Antimicrob. Agents Chemother. July 1999 43: 1542-1548; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antimicrobial Susceptibility and Composition of Microcosm Dental Plaques Supplemented with Sucrose J. Pratten and M. Wilson Antimicrob. Agents Chemother. July 1999 43: 1595-1599; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antifungal Activity and Cytotoxicity of a Novel Membrane-Active Peptide Sung Yu Hong, Jong Eun Oh, and Keun Hyeung Lee Antimicrob. Agents Chemother. July 1999 43: 1704-1707; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of HSR-903, a New Oral Quinolone, against Bacteria Causing Respiratory Infections Akira Watanabe, Yutaka Tokue, Hiroshi Takahashi, Tohru Kikuchi, Takao Kobayashi, Kazunori Gomi, Shigeru Fujimura, and Toshihiro Nukiwa Antimicrob. Agents Chemother. July 1999 43: 1767-1768; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the Everninomicin SCH 27899 and Other Newer Antimicrobial Agents against Borrelia burgdorferi Lisa L. Dever, Christine V. Torigian, and Alan G. Barbour Antimicrob. Agents Chemother. July 1999 43: 1773-1775; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Toxoplasma gondii Activities and Structure-Activity Relationships of Novel Fluoroquinolones Related to Trovafloxacin Anis A. Khan, Fausto G. Araujo, Katherine E. Brighty, Thomas D. Gootz, and Jack S. Remington Antimicrob. Agents Chemother. July 1999 43: 1783-1787; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Tea Catechins against Helicobacter pylori Katsuhiro Mabe, Masami Yamada, Itaro Oguni, and Tsuneo Takahashi Antimicrob. Agents Chemother. July 1999 43: 1788-1791; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Chlamydia pneumoniae Isolates from German Patients and Synergistic Activity of Antibiotic Combinations Heike M. Freidank, Philipp Losch, Heike Vögele, and Margit Wiedmann-Al-Ahmad Antimicrob. Agents Chemother. July 1999 43: 1808-1810; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Pharmacology:

---

Prospective Evaluation of the Effect of an Aminoglycoside Dosing Regimen on Rates of Observed Nephrotoxicity and Ototoxicity Michael J. Rybak, Betty J. Abate, S. Lena Kang, Michael J. Ruffing, Stephen A. Lerner, and George L. Drusano Antimicrob. Agents Chemother. July 1999 43: 1549-1555; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Dirithromycin in Patients with Mild or Moderate Cirrhosis Teresita Mazzei, Calogero Surrenti, Andrea Novelli, Maria Rosa Biagini, Stefania Fallani, Maria Iris Cassetta, Silvia Conti, and Elisabetta Surrenti Antimicrob. Agents Chemother. July 1999 43: 1556-1559; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Moxifloxacin, Administered Once a Day, against Streptococcus pneumoniae in an In Vitro Pharmacodynamic Model of Infection Alasdair P. MacGowan, Karen E. Bowker, Mandy Wootton, and H. Alan Holt Antimicrob. Agents Chemother. July 1999 43: 1560-1564; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Single-Dose Pharmacokinetics and Safety of Abacavir (1592U89), Zidovudine, and Lamivudine Administered Alone and in Combination in Adults with Human Immunodeficiency Virus Infection Laurene H. Wang, Gregory E. Chittick, and James A. McDowell Antimicrob. Agents Chemother. July 1999 43: 1708-1715; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of Novel 6-Desfluoroquinolones and Classic Quinolones on Pentylenetetrazole-Induced Seizures in Mice A. De Sarro, V. Cecchetti, V. Fravolini, F. Naccari, O. Tabarrini, and G. De Sarro Antimicrob. Agents Chemother. July 1999 43: 1729-1736; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Altered Pharmacokinetics of Ceftazidime in Critically Ill Patients C. M. H. Gómez, J. J. Cordingly, and M. G. A. Palazzo Antimicrob. Agents Chemother. July 1999 43: 1798-1802; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Chemistry; Biosynthesis:

---

Identification and Analysis of the Balhimycin Biosynthetic Gene Cluster and Its Use for Manipulating Glycopeptide Biosynthesis in Amycolatopsis mediterranei DSM5908 S. Pelzer, R. Süßmuth, D. Heckmann, J. Recktenwald, P. Huber, G. Jung, and W. Wohlleben Antimicrob. Agents Chemother. July 1999 43: 1565-1573; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nonactin Biosynthesis: the Product of nonS Catalyzes the Formation of the Furan Ring of Nonactic Acid Anton J. Woo, William R. Strohl, and Nigel D. Priestley Antimicrob. Agents Chemother. July 1999 43: 1662-1668; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Action:

---

DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones Anne Y. C. Saiki, Linus L. Shen, Chih-Ming Chen, John Baranowski, and Claude G. Lerner Antimicrob. Agents Chemother. July 1999 43: 1574-1577; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple Mechanisms of Action for Inhibitors of Histidine Protein Kinases from Bacterial Two-Component Systems Jamese J. Hilliard, Raul M. Goldschmidt, Lisa Licata, Ellen Z. Baum, and Karen Bush Antimicrob. Agents Chemother. July 1999 43: 1693-1699; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antifungal Properties and Target Evaluation of Three Putative Bacterial Histidine Kinase Inhibitors Robert J. Deschenes, Hong Lin, Addison D. Ault, and Jan S. Fassler Antimicrob. Agents Chemother. July 1999 43: 1700-1703; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Purification, Reconstitution, and Inhibition of Cytochrome P-450 Sterol 22-Desaturase from the Pathogenic Fungus Candida glabrata David C. Lamb, Segula Maspahy, Diane E. Kelly, Nigel J. Manning, Antonia Geber, John E. Bennett, and Steven L. Kelly Antimicrob. Agents Chemother. July 1999 43: 1725-1728; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Mechanisms of Resistance:

---

Cloning and Characterization of a Gene, pbpF, Encoding a New Penicillin-Binding Protein, PBP2B, in Staphylococcus aureus Hitoshi Komatsuzawa, Gil H. Choi, Kouji Ohta, Motoyuki Sugai, Monique T. Tran, and Hidekazu Suginaka Antimicrob. Agents Chemother. July 1999 43: 1578-1583; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Cloning and Characterization of blaVIM, a New Integron-Borne Metallo--Lactamase Gene from a Pseudomonas aeruginosa Clinical Isolate Laura Lauretti, Maria Letizia Riccio, Annarita Mazzariol, Giuseppe Cornaglia, Gianfranco Amicosante, Roberta Fontana, and Gian Maria Rossolini Antimicrob. Agents Chemother. July 1999 43: 1584-1590; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

-Lactamase Production by Oral Anaerobic Gram-Negative Species in Infants in Relation to Previous Antimicrobial Therapy S. Nyfors, E. Könönen, A. Takala, and H. Jousimies-Somer Antimicrob. Agents Chemother. July 1999 43: 1591-1594; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Multiple Resistant Phenotypes of Candida albicans Coexist during Episodes of Oropharyngeal Candidiasis in Human Immunodeficiency Virus-Infected Patients Jose L. Lopez-Ribot, Robert K. McAtee, Sofia Perea, William R. Kirkpatrick, Michael G. Rinaldi, and Thomas F. Patterson Antimicrob. Agents Chemother. July 1999 43: 1621-1630; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Topoisomerase Sequences of Coagulase-Negative Staphylococcal Isolates Resistant to Ciprofloxacin or Trovafloxacin Donald T. Dubin, Joseph E. Fitzgibbon, Massoumeh D. Nahvi, and Joseph F. John Antimicrob. Agents Chemother. July 1999 43: 1631-1637; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Biochemical-Genetic Analysis and Distribution of FAR-1, a Class A -Lactamase from Nocardia farcinica Frederic Laurent, Laurent Poirel, Thierry Naas, El Bachir Chaibi, Roger Labia, Patrick Boiron, and Patrice Nordmann Antimicrob. Agents Chemother. July 1999 43: 1644-1650; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of TEM-59 (IRT-17), a Novel Inhibitor-Resistant TEM-Derived -Lactamase in a Clinical Isolate of Klebsiella oxytoca H. Bermudes, F. Jude, E. B. Chaibi, C. Arpin, C. Bebear, R. Labia, and C. Quentin Antimicrob. Agents Chemother. July 1999 43: 1657-1661; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Roles of -Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae Luis Martínez-Martínez, Alvaro Pascual, Santiago Hernández-Allés, Dolores Alvarez-Díaz, Ana Isabel Suárez, John Tran, Vicente Javier Benedí, and George A. Jacoby Antimicrob. Agents Chemother. July 1999 43: 1669-1673; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Structural Alterations in the Translational Attenuator of Constitutively Expressed ermC Genes Christiane Werckenthin, Stefan Schwarz, and Henrik Westh Antimicrob. Agents Chemother. July 1999 43: 1681-1685; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Reversal of Tetracycline Resistance Mediated by Different Bacterial Tetracycline Resistance Determinants by an Inhibitor of the Tet(B) Antiport Protein Mark L. Nelson and Stuart B. Levy Antimicrob. Agents Chemother. July 1999 43: 1719-1724; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Class C -Lactamases Operate at the Diffusion Limit for Turnover of Their Preferred Cephalosporin Substrates Alexey Bulychev and Shahriar Mobashery Antimicrob. Agents Chemother. July 1999 43: 1743-1746; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Fluoroquinolone Concentration on Selection of Resistant Mutants of Mycobacterium bovis BCG and Staphylococcus aureus Yuzhi Dong, Xilin Zhao, John Domagala, and Karl Drlica Antimicrob. Agents Chemother. July 1999 43: 1756-1758; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequence of the MIR-1 -Lactamase Gene George A. Jacoby and John Tran Antimicrob. Agents Chemother. July 1999 43: 1759-1760; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of New Mutations in Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Identification of Conserved Regions Important for the Catalytic Activity of the Pyrazinamidase PncA Nadine Lemaitre, Wladimir Sougakoff, Chantal Truffot-Pernot, and Vincent Jarlier Antimicrob. Agents Chemother. July 1999 43: 1761-1763; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis Isolates from Northwestern Russia Harri J. Marttila, Merja Marjamäki, Elena Vyshnevskaya, Boris I. Vyshnevskiy, Tatjana F. Otten, Alexandr V. Vasilyef, and Matti K. Viljanen Antimicrob. Agents Chemother. July 1999 43: 1764-1766; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activation of the 2'-N-Acetyltransferase Gene [aac(2')-Ia] in Providencia stuartii by an Interaction of AarP with the Promoter Region David R. Macinga, Michael R. Paradise, Milica M. Parojcic, and Philip N. Rather Antimicrob. Agents Chemother. July 1999 43: 1769-1772; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Rapid Detection, by PCR and Reverse Hybridization, of Mutations in the Helicobacter pylori 23S rRNA Gene, Associated with Macrolide Resistance Leen-Jan van Doorn, Yvette J. Debets-Ossenkopp, Armelle Marais, Ricardo Sanna, Francis Mégraud, Johannes G. Kusters, and Wim G. V. Quint Antimicrob. Agents Chemother. July 1999 43: 1779-1782; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of a Novel -Lactamase Produced by Xanthomonas campestris, a Phytopathogenic Bacterium Shu-Fen Weng, Chun-Yi Chen, Yeong-Sheng Lee, Juey-Wen Lin, and Yi-Hsiung Tseng Antimicrob. Agents Chemother. July 1999 43: 1792-1797; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sensitivity of Amoxicillin-Resistant Helicobacter pylori to Other Penicillins Maria P. Dore, David Y. Graham, Antonia R. Sepulveda, Giuseppe Realdi, and Michael S. Osato Antimicrob. Agents Chemother. July 1999 43: 1803-1804; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Antiviral Agents:

---

Use of Real-Time PCR and Fluorimetry To Detect Lamivudine Resistance-Associated Mutations in Hepatitis B Virus Patricia A. Cane, Pamela Cook, Daina Ratcliffe, David Mutimer, and Deenan Pillay Antimicrob. Agents Chemother. July 1999 43: 1600-1608; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety and Efficacy of Intravenous Zanamivir in Preventing Experimental Human Influenza A Virus Infection David P. Calfee, Amy W. Peng, Lindsey M. Cass, Monica Lobo, and Frederick G. Hayden Antimicrob. Agents Chemother. July 1999 43: 1616-1620; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequence Diversity of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 from Untreated Brazilian Individuals Rodrigo Brindeiro, Bart Vanderborght, Elena Caride, Letícia Correa, Rejane M. Oravec, Oscar Berro, Lieven Stuyver, and Amilcar Tanuri Antimicrob. Agents Chemother. July 1999 43: 1674-1680; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety and Pharmacokinetics of Amprenavir (141W94), a Human Immunodeficiency Virus (HIV) Type 1 Protease Inhibitor, following Oral Administration of Single Doses to HIV-Infected Adults Brian M. Sadler, Cynthia D. Hanson, Gregory E. Chittick, William T. Symonds, and Neil S. Roskell Antimicrob. Agents Chemother. July 1999 43: 1686-1692; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Experimental Therapeutics:

---

Efficacy of Locally Delivered Polyclonal Immunoglobulin against Pseudomonas aeruginosa Peritonitis in a Murine Model Nazir A. Barekzi, Kornelis A. Poelstra, Adrian G. Felts, Ignacio A. Rojas, Jeffrey B. Slunt, and David W. Grainger Antimicrob. Agents Chemother. July 1999 43: 1609-1615; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effective Treatment of Acute and Chronic Murine Tuberculosis with Liposome-Encapsulated Clofazimine Linda B. Adams, Indu Sinha, Scott G. Franzblau, James L. Krahenbuhl, and Reeta T. Mehta Antimicrob. Agents Chemother. July 1999 43: 1638-1643; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Efficacies of Antibiotics in a Rat Model of Meningoencephalitis Due to Listeria monocytogenes Christian Michelet, Stephen L. Leib, Daniele Bentue-Ferrer, and Martin G. Täuber Antimicrob. Agents Chemother. July 1999 43: 1651-1656; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Sordarins in Murine Histoplasmosis John R. Graybill, Laura Najvar, Annette Fothergill, Rosie Bocanegra, and Federico Gomez de las Heras Antimicrob. Agents Chemother. July 1999 43: 1716-1718; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative Efficacies of Liposomal Amikacin (MiKasome) plus Oxacillin versus Conventional Amikacin plus Oxacillin in Experimental Endocarditis Induced by Staphylococcus aureus: Microbiological and Echocardiographic Analyses Yan-Qiong Xiong, Leon Iri Kupferwasser, Philip M. Zack, and Arnold S. Bayer Antimicrob. Agents Chemother. July 1999 43: 1737-1742; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Combinations of Vancomycin and -Lactams Are Synergistic against Staphylococci with Reduced Susceptibilities to Vancomycin Michael W. Climo, Roberto L. Patron, and Gordon L. Archer Antimicrob. Agents Chemother. July 1999 43: 1747-1753; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Lysostaphin Treatment of Experimental Aortic Valve Endocarditis Caused by a Staphylococcus aureus Isolate with Reduced Susceptibility to Vancomycin Roberto L. Patron, Michael W. Climo, Beth P. Goldstein, and Gordon L. Archer Antimicrob. Agents Chemother. July 1999 43: 1754-1755; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Improvement of In Vitro and In Vivo Antileishmanial Activities of 2',6'-Dihydroxy-4'-Methoxychalcone by Entrapment in Poly(D,L-Lactide) Nanoparticles Eduardo Caio Torres-Santos, José M. Rodrigues, Jr., Davyson L. Moreira, Maria Auxiliadora C. Kaplan, and Bartira Rossi-Bergmann Antimicrob. Agents Chemother. July 1999 43: 1776-1778; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Gatifloxacin in Experimental Escherichia coli Meningitis Irja Lutsar, Ian R. Friedland, Hasan S. Jafri, Loretta Wubbel, Winston Ng, Faryal Ghaffar, and George H. McCracken, Jr. Antimicrob. Agents Chemother. July 1999 43: 1805-1807; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

---

Letters:

---

In Vitro Inhibition of the Growth of Helicobacter pylori by Oil-Macerated Garlic Constituents Rie Ohta, Norihiko Yamada, Hisae Kaneko, Keiko Ishikawa, Hiroyuki Fukuda, Tsuchiyoshi Fujino, and Atsushi Suzuki Antimicrob. Agents Chemother. July 1999 43: 1811-1812; [Full Text] [PDF] [Reprints and Permissions]

Characterization of a New Enterococcal Gene, satG, Encoding a Putative Acetyltransferase Conferring Resistance to Streptogramin A Compounds G. Werner and W. Witte Antimicrob. Agents Chemother. July 1999 43: 1813-1814; [Full Text] [PDF] [Reprints and Permissions]

Ritonavir-Fluoxetine Interaction S. Eralp Bellibas;, Daniele Ouellet, and Ann Hsu Antimicrob. Agents Chemother. July 1999 43: 1815 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.