Contents: August 1999, Volume 43, Issue 8        Minireviews        Antiviral Agents        Mechanisms of Resistance        Susceptibility        Experimental Therapeutics        Pharmacology        Mechanisms of Action        Clinical Therapeutics        Letters        Errata Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Antiretroviral-Drug Concentrations in Semen: Implications for Sexual Transmission of Human Immunodeficiency Virus Type 1 Angela D. M. Kashuba, John R. Dyer, Linda M. Kramer, Ralph H. Raasch, Joseph J. Eron, and Myron S. Cohen Antimicrob. Agents Chemother. August 1999 43: 1817-1826; [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Unique Anti-Human Immunodeficiency Virus Activities of the Nonnucleoside Reverse Transcriptase Inhibitors Calanolide A, Costatolide, and Dihydrocostatolide Robert W. Buckheit, Jr., E. Lucile White, Valerie Fliakas-Boltz, Julie Russell, Tracy L. Stup, Tracy L. Kinjerski, Mark C. Osterling, Ann Weigand, and John P. Bader Antimicrob. Agents Chemother. August 1999 43: 1827-1834; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Anti-Human Immunodeficiency Virus Type 1 Activity, Intracellular Metabolism, and Pharmacokinetic Evaluation of 2'-Deoxy-3'-Oxa-4'-Thiocytidine Jean-Marc de Muys, Henriette Gourdeau, Nghe Nguyen-Ba, Debra L. Taylor, Parvin S. Ahmed, Tarek Mansour, Celine Locas, Nathalie Richard, Mark A. Wainberg, and Robert F. Rando Antimicrob. Agents Chemother. August 1999 43: 1835-1844; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Nonnucleoside Pyrrolopyrimidines with a Unique Mechanism of Action against Human Cytomegalovirus Jennie G. Jacobson, Thomas E. Renau, M. Reza Nassiri, Dominica G. Sweier, Julie M. Breitenbach, Leroy B. Townsend, and John C. Drach Antimicrob. Agents Chemother. August 1999 43: 1888-1894; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Acyclovir Is Phosphorylated by the Human Cytomegalovirus UL97 Protein Christine L. Talarico, Thimysta C. Burnette, Wayne H. Miller, Sheila L. Smith, Michelle G. Davis, Sylvia C. Stanat, Teresa I. Ng, Zuwen He, Donald M. Coen, Bernard Roizman, and Karen K. Biron Antimicrob. Agents Chemother. August 1999 43: 1941-1946; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Emergence of Drug-Resistant Populations of Woodchuck Hepatitis Virus in Woodchucks Treated with the Antiviral Nucleoside Lamivudine Tianlun Zhou, Jeffry Saputelli, Carol E. Aldrich, Manon Deslauriers, Lynn D. Condreay, and William S. Mason Antimicrob. Agents Chemother. August 1999 43: 1947-1954; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Family of Insertion Mutations between Codons 67 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Multinucleoside Analog Resistance B. A. Larder, S. Bloor, S. D. Kemp, Kurt Hertogs, R. L. Desmet, V. Miller, M. Sturmer, S. Staszewski, J. Ren, D. K. Stammers, D. I. Stuart, and R. Pauwels Antimicrob. Agents Chemother. August 1999 43: 1961-1967; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of the Hepatitis B Virus Recombinant Baculovirus-HepG2 System to Study the Effects of ()--2',3'-Dideoxy-3'-Thiacytidine on Replication of Hepatitis B Virus and Accumulation of Covalently Closed Circular DNA William E. Delaney, IV, Thomas G. Miller, and Harriet C. Isom Antimicrob. Agents Chemother. August 1999 43: 2017-2026; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hydroxyurea Enhances the Activities of Didanosine, 9-[2-(Phosphonylmethoxy)ethyl]adenine, and 9-[2-(Phosphonylmethoxy)propyl]adenine against Drug-Susceptible and Drug-Resistant Human Immunodeficiency Virus Isolates Sarah Palmer, Robert W. Shafer, and Thomas C. Merigan Antimicrob. Agents Chemother. August 1999 43: 2046-2050; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A New Point Mutation (P157S) in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Confers Low-Level Resistance to ()--2',3'-Dideoxy-3'-Thiacytidine Robert A. Smith, George J. Klarmann, Kirsten M. Stray, Uta K. von Schwedler, Raymond F. Schinazi, Bradley D. Preston, and Thomas W. North Antimicrob. Agents Chemother. August 1999 43: 2077-2080; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Activities of Trovafloxacin Compared with Those of Other Fluoroquinolones against Purified Topoisomerases and gyrA and grlA Mutants of Staphylococcus aureus Thomas D. Gootz, Richard P. Zaniewski, Suzanne L. Haskell, Frank S. Kaczmarek, and Alison E. Maurice Antimicrob. Agents Chemother. August 1999 43: 1845-1855; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Heteroresistance to Fluconazole and Voriconazole in Cryptococcus neoformans P. Mondon, R. Petter, G. Amalfitano, R. Luzzati, E. Concia, I. Polacheck, and K. J. Kwon-Chung Antimicrob. Agents Chemother. August 1999 43: 1856-1861; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Physiological Cost of Rifampin Resistance Induced In Vitro in Mycobacterium tuberculosis O. J. Billington, T. D. McHugh, and S. H. Gillespie Antimicrob. Agents Chemother. August 1999 43: 1866-1869; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Moderate-Level Resistance to Glycopeptide LY333328 Mediated by Genes of the vanA and vanB Clusters in Enterococci Michel Arthur, Florence Depardieu, Peter Reynolds, and Patrice Courvalin Antimicrob. Agents Chemother. August 1999 43: 1875-1880; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Construction and Characterization of Mutants of the TEM-1 -Lactamase Containing Amino Acid Substitutions Associated with both Extended-Spectrum Resistance and Resistance to -Lactamase Inhibitors Paul D. Stapleton, Kevin P. Shannon, and Gary L. French Antimicrob. Agents Chemother. August 1999 43: 1881-1887; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Type of AmpC -Lactamase, ACC-1, Produced by a Klebsiella pneumoniae Strain Causing Nosocomial Pneumonia Adolf Bauernfeind, Ines Schneider, Renate Jungwirth, Hany Sahly, and Uwe Ullmann Antimicrob. Agents Chemother. August 1999 43: 1924-1931; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Phenotypes and Genotypes of Erythromycin-Resistant Streptococcus pyogenes Strains in Italy and Heterogeneity of Inducibly Resistant Strains Eleonora Giovanetti, Maria Pia Montanari, Marina Mingoia, and Pietro Emanuele Varaldo Antimicrob. Agents Chemother. August 1999 43: 1935-1940; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antagonism of Azole Activity against Candida albicans following Induction of Multidrug Resistance Genes by Selected Antimicrobial Agents Karl W. Henry, M. Cristina Cruz, Santosh K. Katiyar, and Thomas D. Edlind Antimicrob. Agents Chemother. August 1999 43: 1968-1974; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of Topoisomerase IV and DNA Gyrase Mutations in Streptococcus pneumoniae to Resistance to Novel Fluoroquinolones Ekaterina Pestova, Rebecca Beyer, Nicholas P. Cianciotto, Gary A. Noskin, and Lance R. Peterson Antimicrob. Agents Chemother. August 1999 43: 2000-2004; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of Glycopeptide-Resistant Enterococcus faecium Isolates and Glycopeptide Resistance Genes of Human and Animal Origins Patrick R. M. Descheemaeker, Sabine Chapelle, Luc A. Devriese, Patrick Butaye, Peter Vandamme, and Herman Goossens Antimicrob. Agents Chemother. August 1999 43: 2032-2037; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Identification of Functional Amino Acids in the Macrolide 2'-Phosphotransferase II Kazuo Taniguchi, Akio Nakamura, Kazue Tsurubuchi, Aki Ishii, Koji O'Hara, and Tetsuo Sawai Antimicrob. Agents Chemother. August 1999 43: 2063-2065; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

TEM-24 Produced by Four Different Species of Enterobacteriaceae, Including Providencia rettgeri, in a Single Patient Helene Marchandin, Christian Carriere, Danielle Sirot, Helene Jean- Pierre, and Helene Darbas Antimicrob. Agents Chemother. August 1999 43: 2069-2073; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Molecular Characterization of the SHV-11 -Lactamase of Shigella dysenteriae Jasimuddin Ahamed and Manikuntala Kundu Antimicrob. Agents Chemother. August 1999 43: 2081-2083; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Permeability in the Activities of -Lactams against Gram-Negative Bacteria Which Produce a Group 3 -Lactamase Naoki Matsumura, Shinzaburo Minami, Yasuo Watanabe, Shizuko Iyobe, and Susumu Mitsuhashi Antimicrob. Agents Chemother. August 1999 43: 2084-2086; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Contribution of kasA Analysis to Detection of Isoniazid-Resistant Mycobacterium tuberculosis in Singapore Ann S. G. Lee, Irene H. K. Lim, Lynn L. H. Tang, Amalio Telenti, and Sin Yew Wong Antimicrob. Agents Chemother. August 1999 43: 2087-2089; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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Effect of Carbon Dioxide on Testing of Susceptibilities of Respiratory Tract Pathogens to Macrolide and Azalide Antimicrobial Agents M. M. Johnson, S. L. Hill, and Laura J. V. Piddock Antimicrob. Agents Chemother. August 1999 43: 1862-1865; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro and In Vivo Activities of Syn2190, a Novel -Lactamase Inhibitor Kouichi Nishida, Chieko Kunugita, Tatsuya Uji, Fusahiro Higashitani, Akio Hyodo, Norio Unemi, Samarendra N. Maiti, Oludotun A. Phillips, Paul Spevak, Kevin P. Atchison, Sameeh M. Salama, Harninder Atwal, and Ronald G. Micetich Antimicrob. Agents Chemother. August 1999 43: 1895-1900; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 Oral Antimicrobial Agents Based on Pharmacodynamic Parameters: 1997 U.S. Surveillance Study Michael R. Jacobs, Saralee Bajaksouzian, Anne Zilles, Gengrong Lin, Glenn A. Pankuch, and Peter C. Appelbaum Antimicrob. Agents Chemother. August 1999 43: 1901-1908; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Inhibitors of DNA Polymerase III as Novel Antimicrobial Agents against Gram-Positive Eubacteria Paul M. Tarantino, Jr., Chengxin Zhi, George E. Wright, and Neal C. Brown Antimicrob. Agents Chemother. August 1999 43: 1982-1987; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Antibacterial Activity of LJC 11,036, an Active Metabolite of L-084, a New Oral Carbapenem Antibiotic with Potent Antipneumococcal Activity Muneo Hikida, Kouju Itahashi, Atsumi Igarashi, Toshiharu Shiba, and Masataka Kitamura Antimicrob. Agents Chemother. August 1999 43: 2010-2016; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activity of Telithromycin (HMR 3647) against Anaerobic Bacteria Compared to Those of Eight Other Agents by Time-Kill Methodology Kim L. Credito, Lois M. Ednie, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. August 1999 43: 2027-2031; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinupristin-Dalfopristin Is Active against Toxoplasma gondii Anis A. Khan, Teri R. Slifer, Fausto G. Araujo, and Jack S. Remington Antimicrob. Agents Chemother. August 1999 43: 2043-2045; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes Clinical Isolates with Alterations in GyrA and ParC Proteins Sylvain Brisse, Dana Milatovic, Ad C. Fluit, Jan Verhoef, Nele Martin, Sybille Scheuring, Karl Köhrer, and Franz-Josef Schmitz Antimicrob. Agents Chemother. August 1999 43: 2051-2055; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Linezolid against Important Gram-Positive Bacterial Pathogens Including Vancomycin-Resistant Enterococci Gary A. Noskin, Farida Siddiqui, Valentina Stosor, Donna Hacek, and Lance R. Peterson Antimicrob. Agents Chemother. August 1999 43: 2059-2062; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Four Bartonella bacilliformis Strains to 30 Antibiotic Compounds Mireille Sobraquès, Max Maurin, Richard J. Birtles, and Didier Raoult Antimicrob. Agents Chemother. August 1999 43: 2090-2092; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of Polycationic Peptides Alone and in Combination with Clinically Used Antimicrobial Agents against Rhodococcus equi A. Giacometti, O. Cirioni, F. Ancarani, M. S. Del Prete, M. Fortuna, and G. Scalise Antimicrob. Agents Chemother. August 1999 43: 2093-2096; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Mefloquine Is Active In Vitro and In Vivo against Mycobacterium avium Complex Luiz E. Bermudez, Peter Kolonoski, Martin Wu, Priscilla A. Aralar, Clark B. Inderlied, and Lowell S. Young Antimicrob. Agents Chemother. August 1999 43: 1870-1874; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Analysis of Vancomycin Population Susceptibility Profiles, Killing Activity, and Postantibiotic Effect against Vancomycin-Intermediate Staphylococcus aureus Jeffrey R. Aeschlimann, Ellie Hershberger, and Michael J. Rybak Antimicrob. Agents Chemother. August 1999 43: 1914-1918; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activity of Vancomycin in Cerebrospinal Fluid Markus Nagl, Claudia Neher, Josef Hager, Bettina Pfausler, Erich Schmutzhard, and Franz Allerberger Antimicrob. Agents Chemother. August 1999 43: 1932-1934; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Injectable Water-Soluble Amphotericin B-Arabinogalactan Conjugate Rama Falk, Abraham J. Domb, and Itzhack Polacheck Antimicrob. Agents Chemother. August 1999 43: 1975-1981; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Evaluation of Low-Dose, Extended-Interval Clindamycin Regimens against Staphylococcus aureus and Streptococcus pneumoniae Using a Dynamic In Vitro Model of Infection Russell E. Lewis, Michael E. Klepser, Erika J. Ernst, Brian C. Lund, Douglas J. Biedenbach, and Ronald N. Jones Antimicrob. Agents Chemother. August 1999 43: 2005-2009; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Stability of Antibiotics Used for Antibiotic-Lock Treatment of Infections of Implantable Venous Devices (Ports) Thiele Umali Anthony and Lorry G. Rubin Antimicrob. Agents Chemother. August 1999 43: 2074-2076; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Gastric Penetration of Amoxicillin in a Human Helicobacter pylori-Infected Xenograft Model Alain Lozniewski, Adrien Duprez, Corinne Renault, Filipe Muhale, Marie-Christine Conroy, Michele Weber, Alain Le Faou, and Francois Jehl Antimicrob. Agents Chemother. August 1999 43: 1909-1913; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Pharmacokinetics of Enrofloxacin and Danofloxacin in Plasma, Inflammatory Exudate, and Bronchial Secretions of Calves following Subcutaneous Administration Quintin McKellar, Ian Gibson, Ana Monteiro, and Miguel Bregante Antimicrob. Agents Chemother. August 1999 43: 1988-1992; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effects of the Human Immunodeficiency Virus (HIV) Proteinase Inhibitors Saquinavir and Indinavir on In Vitro Activities of Secreted Aspartyl Proteinases of Candida albicans Isolates from HIV-Infected Patients Hans C. Korting, Martin Schaller, Gabriele Eder, Gerald Hamm, Ursula Böhmer, and Bernhard Hube Antimicrob. Agents Chemother. August 1999 43: 2038-2042; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Penetration of Ciprofloxacin into the Interstitial Space of Inflamed Foot Lesions in Non-Insulin-Dependent Diabetes Mellitus Patients Markus Müller, Martin Brunner, Ursula Hollenstein, Christian Joukhadar, Rainer Schmid, Erich Minar, Herbert Ehringer, and Hans Georg Eichler Antimicrob. Agents Chemother. August 1999 43: 2056-2058; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Inhibition of Polyamine Synthesis Arrests Trichomonad Growth and Induces Destruction of Hydrogenosomes Isabela A. Reis, Martha P. Martinez, Nigel Yarlett, Patricia J. Johnson, Fernando C. Silva-Filho, and Marcos A. Vannier-Santos Antimicrob. Agents Chemother. August 1999 43: 1919-1923; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Unusual Antimicrotubule Activity of the Antifungal Agent Spongistatin 1 Yulia Y. Ovechkina, Robin K. Pettit, Zbigniew A. Cichacz, George R. Pettit, and Berl R. Oakley Antimicrob. Agents Chemother. August 1999 43: 1993-1999; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antitrypanosomal Activity of Fluoroquinolones Elizabeth Nenortas, Christian Burri, and Theresa A. Shapiro Antimicrob. Agents Chemother. August 1999 43: 2066-2068; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Safety and Tolerability of Fluconazole in Children Vas Novelli and Helen Holzel Antimicrob. Agents Chemother. August 1999 43: 1955-1960; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Plasmid-Mediated Coresistance to Streptogramins and Vancomycin in Enterococcus faecium HM1032 Bülent Bozdogan, Roland Leclercq, Alain Lozniewski, and Michèle Weber Antimicrob. Agents Chemother. August 1999 43: 2097-2098; [Full Text] [PDF] [Reprints and Permissions]

Diminished Killing of Pneumococci by Pristinamycin Demonstrated by Time-Kill Studies Laurent Schlegel, Geneviève Sissia, Annick Frémaux, and Pierre Geslin Antimicrob. Agents Chemother. August 1999 43: 2099-2100; [Full Text] [PDF] [Reprints and Permissions]

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Errata:

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In Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous System Hideki Kita, Hirotami Matsuo, Hitomi Takanaga, Junichi Kawakami, Koujirou Yamamoto, Tatsuji Iga, Mikihiko Naito, Takashi Tsuruo, Atsushi Asanuma, Keiji Yanagisawa, and Yasufumi Sawada Antimicrob. Agents Chemother. August 1999 43: 2101 [Full Text] [PDF] [Reprints and Permissions]

Altered Pharmacokinetics of Ceftazidime in Critically Ill Patients C. M. H. Gómez, J. J. Cordingley, and M. G. A. Palazzo Antimicrob. Agents Chemother. August 1999 43: 2101 [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.