Contents: January 2000, Volume 44, Issue 1        Mechanisms of Resistance        Mechanisms of Action        Experimental Therapeutics        Susceptibility        Antiviral Agents        Clinical Therapeutics        Pharmacology Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Mechanisms of Resistance:

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Genetic-Biochemical Analysis and Distribution of the Ambler Class A -Lactamase CME-2, Responsible for Extended-Spectrum Cephalosporin Resistance in Chryseobacterium (Flavobacterium) meningosepticum Samuel Bellais, Laurent Poirel, Thierry Naas, Delphine Girlich, and Patrice Nordmann Antimicrob. Agents Chemother. January 2000 44: 1-9; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ineffectiveness of Topoisomerase Mutations in Mediating Clinically Significant Fluoroquinolone Resistance in Escherichia coli in the Absence of the AcrAB Efflux Pump Margret Oethinger, Winfried V. Kern, Angelika S. Jellen-Ritter, Laura M. McMurry, and Stuart B. Levy Antimicrob. Agents Chemother. January 2000 44: 10-13; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Aminoglycoside Resistance in Mycobacterium kansasii, Mycobacterium avium-M. intracellulare, and Mycobacterium fortuitum: Are Aminoglycoside-Modifying Enzymes Responsible? I. I. Y. Ho, C. Y. Chan, and A. F. B. Cheng Antimicrob. Agents Chemother. January 2000 44: 39-42; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The R467K Amino Acid Substitution in Candida albicans Sterol 14-Demethylase Causes Drug Resistance through Reduced Affinity David C. Lamb, Diane E. Kelly, Theodore C. White, and Steven L. Kelly Antimicrob. Agents Chemother. January 2000 44: 63-67; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Chemical Specificity of the PDR5 Multidrug Resistance Gene Product of Saccharomyces cerevisiae Based on Studies with Tri-n-Alkyltin Chlorides John Golin, Alisa Barkatt, Susan Cronin, George Eng, and Leopold May Antimicrob. Agents Chemother. January 2000 44: 134-138; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Role of Penicillin-Binding Proteins in the Initiation of the AmpC -Lactamase Expression in Enterobacter cloacae Dieter Pfeifle, Eva Janas, and Bernd Wiedemann Antimicrob. Agents Chemother. January 2000 44: 169-172; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

satG, Conferring Resistance to Streptogramin A, Is Widely Distributed in Enterococcus faecium Strains but Not in Staphylococci Julien Haroche, Jeanine Allignet, Sylvie Aubert, Anthony E. Van Den Bogaard, and Névine El Solh Antimicrob. Agents Chemother. January 2000 44: 190-191; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibilities of Neisseria gonorrhoeae Isolates Containing Amino Acid Substitutions in GyrA, with or without Substitutions in ParC, to Newer Fluoroquinolones and Other Antibiotics Masatoshi Tanaka, Hiroshi Nakayama, Masashi Haraoka, Takeshi Saika, Intetsu Kobayashi, and Seiji Naito Antimicrob. Agents Chemother. January 2000 44: 192-195; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Sequence Analysis of ARI-1, a Novel OXA -Lactamase, Responsible for Imipenem Resistance in Acinetobacter baumannii 6B92 Helen M. Donald, Wendy Scaife, Sebastian G. B. Amyes, and Hilary-Kay Young Antimicrob. Agents Chemother. January 2000 44: 196-199; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Complete Sequence of a -Lactamase-Encoding Plasmid in Neisseria meningitidis Anders Bäckman, Paula Orvelid, Julio A. Vazquez, Ola Sköld, and Per Olcén Antimicrob. Agents Chemother. January 2000 44: 210-212; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Production of a TEM-24 Plasmid-Mediated Extended-Spectrum -Lactamase by a Clinical Isolate of Pseudomonas aeruginosa Helene Marchandin, Helene Jean-Pierre, Christophe De Champs, Danielle Sirot, Helene Darbas, Pierre Francois Perigault, and Christian Carriere Antimicrob. Agents Chemother. January 2000 44: 213-216; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Novel Integron in Salmonella enterica Serovar Enteritidis, Carrying the blaDHA-1 Gene and Its Regulator Gene ampR, Originated from Morganella morganii Charlotte Verdet, Guillaume Arlet, Guilene Barnaud, Philippe H. Lagrange, and Alain Philippon Antimicrob. Agents Chemother. January 2000 44: 222-225; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Effects of Atovaquone and Diospyrin-Based Drugs on Ubiquinone Biosynthesis in Pneumocystis carinii Organisms Edna S. Kaneshiro, Donggeun Sul, and Banasri Hazra Antimicrob. Agents Chemother. January 2000 44: 14-18; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activity of Riboflavin against the Human Malaria Parasite Plasmodium falciparum Thomas Akompong, Nafisa Ghori, and Kasturi Haldar Antimicrob. Agents Chemother. January 2000 44: 88-96; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin M. Cristina Cruz, Maurizio Del Poeta, Ping Wang, Roland Wenger, Gerhard Zenke, Valerie F. J. Quesniaux, N. Rao Movva, John R. Perfect, Maria E. Cardenas, and Joseph Heitman Antimicrob. Agents Chemother. January 2000 44: 143-149; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Postantibiotic Effects of Grepafloxacin Compared to Those of Five Other Agents against 12 Gram-Positive and -Negative Bacteria Sheila K. Spangler, Saralee Bajaksouzian, Michael R. Jacobs, and Peter C. Appelbaum Antimicrob. Agents Chemother. January 2000 44: 186-189; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Therapeutic Efficacy of Human Macrophage Colony-Stimulating Factor, Used Alone and in Combination with Antifungal Agents, in Mice with Systemic Candida albicans Infection Tetsuya Kuhara, Katsuhisa Uchida, and Hideyo Yamaguchi Antimicrob. Agents Chemother. January 2000 44: 19-23; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of the Triazole Derivative SCH 56592 (Posaconazole) against Drug-Resistant Strains of the Protozoan Parasite Trypanosoma (Schizotrypanum) cruzi in Immunocompetent and Immunosuppressed Murine Hosts Judith Molina, Olindo Martins-Filho, Zigman Brener, Alvaro J. Romanha, David Loebenberg, and Julio A. Urbina Antimicrob. Agents Chemother. January 2000 44: 150-155; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Development of a Long-Term Ascending Urinary Tract Infection Mouse Model for Antibiotic Treatment Studies Hanne Hvidberg, Carsten Struve, Karen A. Krogfelt, Nils Christensen, Søren N. Rasmussen, and Niels Frimodt-Møller Antimicrob. Agents Chemother. January 2000 44: 156-163; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Morphological Change in Pseudomonas aeruginosa following Antibiotic Treatment of Experimental Infection in Mice and Its Relation to Susceptibility to Phagocytosis and to Release of Endotoxin Takashi Yokochi, Kayou Narita, Akiko Morikawa, Kazuko Takahashi, Yutaka Kato, Tuyoshi Sugiyama, Naoki Koide, Makoto Kawai, Masako Fukada, and Tomoaki Yoshida Antimicrob. Agents Chemother. January 2000 44: 205-206; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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MICs of Mutacin B-Ny266, Nisin A, Vancomycin, and Oxacillin against Bacterial Pathogens Marilaine Mota-Meira, Gisèle Lapointe, Christophe Lacroix, and Marc C. Lavoie Antimicrob. Agents Chemother. January 2000 44: 24-29; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of a New Lipopeptide Antifungal Agent, FK463, against a Variety of Clinically Important Fungi Shuichi Tawara, Fumiaki Ikeda, Katsuyuki Maki, Yoshihiko Morishita, Kazumi Otomo, Noriko Teratani, Toshio Goto, Masaki Tomishima, Hidenori Ohki, Akira Yamada, Koji Kawabata, Hisashi Takasugi, Kazuo Sakane, Hirokazu Tanaka, Fumio Matsumoto, and Shogo Kuwahara Antimicrob. Agents Chemother. January 2000 44: 57-62; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Synthetic Hybrid Peptides against Anaerobic Bacteria: Aspects of Methodology and Stability Herin Oh, Maria Hedberg, David Wade, and Charlotta Edlund Antimicrob. Agents Chemother. January 2000 44: 68-72; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Genotypic Analysis of Mycobacterium tuberculosis in Two Distinct Populations Using Molecular Beacons: Implications for Rapid Susceptibility Testing Amy S. Piatek, Amalio Telenti, Megan R. Murray, Hiyam El-Hajj, William R. Jacobs, Jr., Fred Russell Kramer, and David Alland Antimicrob. Agents Chemother. January 2000 44: 103-110; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Zinc-Reversible Growth-Inhibitory Activity in Human Empyema Fluid on Antibiotic Microbicidal Activity Peter G. Sohnle and Beth L. Hahn Antimicrob. Agents Chemother. January 2000 44: 139-142; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Susceptibilities of Rapidly Growing Mycobacteria to Telithromycin (HMR 3647) and Seven Other Antimicrobials Ricardo Fernández-Roblas, Jaime Esteban, Froilán Cabria, Juan Carlos López, Maria Soledad Jiménez, and Francisco Soriano Antimicrob. Agents Chemother. January 2000 44: 181-182; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

In Vitro Activities of the New Antifungal Triazole SCH 56592 against Common and Emerging Yeast Pathogens Francesco Barchiesi, Daniela Arzeni, Annette W. Fothergill, Luigi Falconi Di Francesco, Francesca Caselli, Michael G. Rinaldi, and Giorgio Scalise Antimicrob. Agents Chemother. January 2000 44: 226-229; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Efficacies of Topical Formulations of Foscarnet and Acyclovir and of 5-Percent Acyclovir Ointment (Zovirax) in a Murine Model of Cutaneous Herpes Simplex Virus Type 1 Infection Jocelyne Piret, André Désormeaux, Pierrette Gourde, Julianna Juhász, and Michel G. Bergeron Antimicrob. Agents Chemother. January 2000 44: 30-38; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

The CXCR4 Antagonist AMD3100 Efficiently Inhibits Cell-Surface-Expressed Human Immunodeficiency Virus Type 1 Envelope-Induced Apoptosis Julià Blanco, Jordi Barretina, Geoffrey Henson, Gary Bridger, Erik De Clercq, Bonaventura Clotet, and José A. Esté Antimicrob. Agents Chemother. January 2000 44: 51-56; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Zanamivir Susceptibility Monitoring and Characterization of Influenza Virus Clinical Isolates Obtained during Phase II Clinical Efficacy Studies J. M. Barnett, A. Cadman, D. Gor, M. Dempsey, M. Walters, A. Candlin, M. Tisdale, P. J. Morley, I. J. Owens, R. J. Fenton, A. P. Lewis, E. C. J. Claas, G. F. Rimmelzwaan, R. De Groot, and A. D. M. E. Osterhaus Antimicrob. Agents Chemother. January 2000 44: 78-87; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Persistence of Infectious Herpes Simplex Virus Type 2 in the Nervous System in Mice after Antiviral Chemotherapy Alana M. Thackray and Hugh J. Field Antimicrob. Agents Chemother. January 2000 44: 97-102; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of the Antiviral Effect of 2',3'-Dideoxy-2', 3'-Didehydro--L-5-Fluorocytidine in the Duck Hepatitis B Virus Infection Model Franck Le Guerhier, Christian Pichoud, Sylviane Guerret, Michèle Chevallier, Catherine Jamard, Olivier Hantz, Xiu-Yan Li, Shu-Hui Chen, Ivan King, Christian Trépo, Yung-Chi Cheng, and Fabien Zoulim Antimicrob. Agents Chemother. January 2000 44: 111-122; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Safety Assessment, In Vitro and In Vivo, and Pharmacokinetics of Emivirine, a Potent and Selective Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1 G. M. Szczech, P. Furman, G. R. Painter, D. W. Barry, K. Borroto-Esoda, T. B. Grizzle, M. R. Blum, J.-P. Sommadossi, R. Endoh, T. Niwa, M. Yamamoto, and C. Moxham Antimicrob. Agents Chemother. January 2000 44: 123-130; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Masked 2',3'-Dideoxynucleoside Monophosphate Derivatives against Human Immunodeficiency Virus in Resting Macrophages Stefano Aquaro, Orson Wedgwood, Christopher Yarnold, Dominique Cahard, Ranjith Pathinara, Christopher McGuigan, Raffaele Calio', Erik de Clercq, Jan Balzarini, and Carlo Federico Perno Antimicrob. Agents Chemother. January 2000 44: 173-177; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

A Nine-Codon Deletion Mutation in the Cytomegalovirus UL97 Phosphotransferase Gene Confers Resistance to Ganciclovir Sunwen Chou and Camie L. Meichsner Antimicrob. Agents Chemother. January 2000 44: 183-185; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

12-Prostaglandin J2 Is a Potent Inhibitor of Influenza A Virus Replication Francesca Pica, Anna Teresa Palamara, Antonio Rossi, Alessandra De Marco, Carla Amici, and M. Gabriella Santoro Antimicrob. Agents Chemother. January 2000 44: 200-204; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP Joseph A. Vaccaro, K. Mark Parnell, Stephanie A. Terezakis, and Karen S. Anderson Antimicrob. Agents Chemother. January 2000 44: 217-221; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Bacteriologic Efficacies of Oral Azithromycin and Oral Cefaclor in Treatment of Acute Otitis Media in Infants and Young Children Ron Dagan, Eugene Leibovitz, Dan M. Fliss, Alberto Leiberman, Michael R. Jacobs, William Craig, and Pablo Yagupsky Antimicrob. Agents Chemother. January 2000 44: 43-50; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Ciprofloxacin, Lomefloxacin, or Levofloxacin as Treatment for Chronic Osteomyelitis Richard N. Greenberg, Michael T. Newman, Saeed Shariaty, and Richard W. Pectol Antimicrob. Agents Chemother. January 2000 44: 164-166; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Successful Treatment with Nitazoxanide of Enterocytozoon bieneusi Microsporidiosis in a Patient with AIDS Alain Bicart-Sée, Patrice Massip, Marie-Denise Linas, and Annick Datry Antimicrob. Agents Chemother. January 2000 44: 167-168; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Penetration of Rufloxacin into the Cerebrospinal Fluid in Patients with Inflamed and Uninflamed Meninges Maria Vittoria Moretti, Sergio Pauluzzi, and Marina Cesana Antimicrob. Agents Chemother. January 2000 44: 73-77; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparison of the Effects of Liposomal Amphotericin B and Conventional Amphotericin B on Propafenone Metabolism and Hepatic Cytochrome P-450 in Rats G. Inselmann, A. Volkmann, and H. T. Heidemann Antimicrob. Agents Chemother. January 2000 44: 131-133; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Trovafloxacin Concentrations in Airway Fluids of Patients with Severe Community-Acquired Pneumonia R. A. Peleman, V. Van De Velde, P. R. Germonpré, C. Fleurinck, M. T. Rosseel, and R. A. Pauwels Antimicrob. Agents Chemother. January 2000 44: 178-180; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bioavailability of Aciclovir after Oral Administration of Aciclovir and Its Prodrug Valaciclovir to Patients with Leukopenia after Chemotherapy Hlif Steingrimsdottir, Astrid Gruber, Carina Palm, Gunnar Grimfors, Mats Kalin, and Staffan Eksborg Antimicrob. Agents Chemother. January 2000 44: 207-209; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.