Contents: December 2000, Volume 44, Issue 12        Minireviews        Mechanisms of Action        Clinical Therapeutics        Susceptibility        Antiviral Agents        Experimental Therapeutics        Mechanisms of Resistance        Biologic Response Modifiers        Pharmacology        Letters Other Issues

Table of Contents

[Index by Author]

To see an article, click its [Full Text], [Abstract] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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Minireviews:

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Aminoglycosides: Perspectives on Mechanisms of Action and Resistance and Strategies to Counter Resistance Lakshmi P. Kotra, Jalal Haddad, and Shahriar Mobashery Antimicrob. Agents Chemother. December 2000 44: 3249-3256; [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Action:

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Candidacidal Activities of Human Lactoferrin Peptides Derived from the N Terminus Antonella Lupetti, Akke Paulusma-Annema, Mick M. Welling, Sonia Senesi, Jaap T. van Dissel, and Peter H. Nibbering Antimicrob. Agents Chemother. December 2000 44: 3257-3263; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Salivary Histatin 5 and Human Neutrophil Defensin 1 Kill Candida albicans via Shared Pathways Mira Edgerton, Svetlana E. Koshlukova, Marcelo W. B. Araujo, Rashmi C. Patel, Jin Dong, and Jeremy A. Bruenn Antimicrob. Agents Chemother. December 2000 44: 3310-3316; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Interactions of Bacterial Cationic Peptide Antibiotics with Outer and Cytoplasmic Membranes of Pseudomonas aeruginosa Lijuan Zhang, Pawandeep Dhillon, Hong Yan, Susan Farmer, and Robert E. W. Hancock Antimicrob. Agents Chemother. December 2000 44: 3317-3321; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Effect of Subinhibitory Antibiotic Concentrations on Polysaccharide Intercellular Adhesin Expression in Biofilm-Forming Staphylococcus epidermidis Shwan Rachid, Knut Ohlsen, Wolfgang Witte, Jörg Hacker, and Wilma Ziebuhr Antimicrob. Agents Chemother. December 2000 44: 3357-3363; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Presence of Variations in Ribosomal Protein L16 Corresponding to Susceptibility of Enterococci to Oligosaccharides (Avilamycin and Evernimicin) Frank Møller Aarestrup and Lars Bogø Jensen Antimicrob. Agents Chemother. December 2000 44: 3425-3427; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Clinical Therapeutics:

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Monotherapy with Intravenous Followed by Oral High-Dose Ciprofloxacin versus Combination Therapy with Ceftazidime plus Amikacin as Initial Empiric Therapy for Granulocytopenic Patients with Fever Helen Giamarellou, Harry P. Bassaris, George Petrikkos, Wilhelm Busch, Michel Voulgarelis, Anastasia Antoniadou, Elisabeth Grouzi, and Nikolaos Zoumbos Antimicrob. Agents Chemother. December 2000 44: 3264-3271; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Early Bactericidal Activity of Paromomycin (Aminosidine) in Patients with Smear-Positive Pulmonary Tuberculosis P. R. Donald, F. A. Sirgel, T. P. Kanyok, L. H. Danziger, A. Venter, F. J. Botha, D. P. Parkin, H. I. Seifart, B. W. Van de Wal, J. S. Maritz, and D. A. Mitchison Antimicrob. Agents Chemother. December 2000 44: 3285-3287; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Randomized Comparison of Linezolid (PNU-100766) versus Oxacillin-Dicloxacillin for Treatment of Complicated Skin and Soft Tissue Infections Dennis L. Stevens, Leon G. Smith, Jon B. Bruss, Maureen A. McConnell-Martin, Sue E. Duvall, Wesley Mark Todd, and Barry Hafkin Antimicrob. Agents Chemother. December 2000 44: 3408-3413; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Susceptibility:

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In Vitro and In Vivo Activities of LB 10827, a New Oral Cephalosporin, against Respiratory Pathogens Kyong-Sook Paek, Mu-Yong Kim, Chang-Seok Lee, and Hasik Youn Antimicrob. Agents Chemother. December 2000 44: 3272-3277; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Influence of Human Sera on the In Vitro Activity of the Echinocandin Caspofungin (MK-0991) against Aspergillus fumigatus Tom Chiller, Kouros Farrokhshad, Elmer Brummer, and David A. Stevens Antimicrob. Agents Chemother. December 2000 44: 3302-3305; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antibacterial Spectrum of a Novel Des-Fluoro(6) Quinolone, BMS-284756 Joan C. Fung-Tomc, Beatrice Minassian, Benjamin Kolek, Elizabeth Huczko, Lauren Aleksunes, Terry Stickle, Thomas Washo, Elizabeth Gradelski, Lourdes Valera, and Daniel P. Bonner Antimicrob. Agents Chemother. December 2000 44: 3351-3356; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Quinupristin-Dalfopristin Resistance among Gram-Positive Bacteria in Taiwan Kwen-Tay Luh, Po-Ren Hsueh, Lee-Jene Teng, Hui-Ju Pan, Yu-Chi Chen, Jang-Jih Lu, Jiunn-Jong Wu, and Shen-Wu Ho Antimicrob. Agents Chemother. December 2000 44: 3374-3380; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Bactericidal Activities of Antibiotics against Intracellular Francisella tularensis M. Maurin, N. F. Mersali, and D. Raoult Antimicrob. Agents Chemother. December 2000 44: 3428-3431; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Comparative In Vitro Activities of Daptomycin and Vancomycin against Resistant Gram-Positive Pathogens D. R. Snydman, N. V. Jacobus, L. A. McDermott, J. R. Lonks, and J. M. Boyce Antimicrob. Agents Chemother. December 2000 44: 3447-3450; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Short-Term Exposure to Membrane-Active Antibiotics Inhibits Cryptosporidium parvum Infection in Cell Culture Andrea Giacometti, Oscar Cirioni, Maria Simona Del Prete, Francesco Barchiesi, and Giorgio Scalise Antimicrob. Agents Chemother. December 2000 44: 3473-3475; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Susceptibilities of Corynebacterium bovis and Corynebacterium amylocolatum Isolates from Bovine Mammary Glands to 15 Antimicrobial Agents Jeffrey L. Watts and Silvia Rossbach Antimicrob. Agents Chemother. December 2000 44: 3476-3477; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Antiviral Agents:

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Anti-Epstein-Barr Virus (EBV) Activity of -L-5-Iododioxolane Uracil Is Dependent on EBV Thymidine Kinase Toshihiko Kira, Susan P. Grill, Ginger E. Dutschman, Ju-Sheng Lin, Fucheng Qu, Yongseok Choi, Chung K. Chu, and Yung-Chi Cheng Antimicrob. Agents Chemother. December 2000 44: 3278-3284; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of Novel Human Hepatoma Cell Lines with Stable Hepatitis B Virus Secretion for Evaluating New Compounds against Lamivudine- and Penciclovir-Resistant Virus Lei Fu and Yung-Chi Cheng Antimicrob. Agents Chemother. December 2000 44: 3402-3407; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Antiretroviral Agents Inhibit Infection of Human Cells by Porcine Endogenous Retroviruses S. K. Powell, M. E. Gates, G. Langford, M.-L. Gu, C. Lockey, Z. Long, and E. Otto Antimicrob. Agents Chemother. December 2000 44: 3432-3433; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Hepatitis B or Hepatitis C Virus Infection Is a Risk Factor for Severe Hepatic Cytolysis after Initiation of a Protease Inhibitor-Containing Antiretroviral Regimen in Human Immunodeficiency Virus-Infected Patients Marianne Savès, François Raffi, Philippe Clevenbergh, Bruno Marchou, Anne Waldner-Combernoux, Philippe Morlat, Vincent Le Moing, Catherine Rivière, Geneviève Chêne, Catherine Leport, and The APROCO Study Group Antimicrob. Agents Chemother. December 2000 44: 3451-3455; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2'-Deoxynucleoside Triphosphates Peter R. Meyer, Suzanne E. Matsuura, Raymond F. Schinazi, Antero G. So, and Walter A. Scott Antimicrob. Agents Chemother. December 2000 44: 3465-3472; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Experimental Therapeutics:

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Persistence of Chlamydia trachomatis Is Induced by Ciprofloxacin and Ofloxacin In Vitro Ute Dreses-Werringloer, Ingrid Padubrin, Barbara Jürgens-Saathoff, Alan P. Hudson, H. Zeidler, and L. Köhler Antimicrob. Agents Chemother. December 2000 44: 3288-3297; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Polycationic Peptides as Prophylactic Agents against Methicillin-Susceptible or Methicillin-Resistant Staphylococcus epidermidis Vascular Graft Infection Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Luigi Goffi, Federico Mocchegiani, Alessandra Riva, Giorgio Scalise, and Vittorio Saba Antimicrob. Agents Chemother. December 2000 44: 3306-3309; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Photoactive Porphyrin Derivative with Broad-Spectrum Activity against Oral Pathogens In Vitro C. R. Rovaldi, A. Pievsky, N. A. Sole, P. M. Friden, D. M. Rothstein, and P. Spacciapoli Antimicrob. Agents Chemother. December 2000 44: 3364-3367; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacies of Two New Antifungal Agents, the Triazole Ravuconazole and the Echinocandin LY-303366, in an Experimental Model of Invasive Aspergillosis Jenna Roberts, Kathleen Schock, Susan Marino, and Vincent T. Andriole Antimicrob. Agents Chemother. December 2000 44: 3381-3388; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Activities of Sordarins in Experimental Models of Candidiasis, Aspergillosis, and Pneumocystosis Antonio Martinez, Pablo Aviles, Elena Jimenez, Jesus Caballero, and Domingo Gargallo-Viola Antimicrob. Agents Chemother. December 2000 44: 3389-3394; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Efficacy of Telithromycin (HMR 3647) against Enterococci in a Mouse Peritonitis Model Kavindra V. Singh, Karen K. Zscheck, and Barbara E. Murray Antimicrob. Agents Chemother. December 2000 44: 3434-3437; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Linezolid Therapy of Staphylococcus aureus Experimental Osteomyelitis Robin Patel, Kerryl E. Piper, Mark S. Rouse, and James M. Steckelberg Antimicrob. Agents Chemother. December 2000 44: 3438-3440; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Mechanisms of Resistance:

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Characterization of Spontaneous, In Vitro-Selected, Rifampin-Resistant Mutants of Mycobacterium tuberculosis Strain H37Rv Glenn P. Morlock, Bonnie B. Plikaytis, and Jack T. Crawford Antimicrob. Agents Chemother. December 2000 44: 3298-3301; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa Nobuhisa Masuda, Eiko Sakagawa, Satoshi Ohya, Naomasa Gotoh, Hideto Tsujimoto, and Takeshi Nishino Antimicrob. Agents Chemother. December 2000 44: 3322-3327; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mutant Prevention Concentration as a Measure of Fluoroquinolone Potency against Mycobacteria Georg Sindelar, Xilin Zhao, Anthony Liew, Yuzhi Dong, Tao Lu, Jianfeng Zhou, John Domagala, and Karl Drlica Antimicrob. Agents Chemother. December 2000 44: 3337-3343; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Mechanisms and Frequency of Resistance to Premafloxacin in Staphylococcus aureus: Novel Mutations Suggest Novel Drug-Target Interactions Dilek Ince and David C. Hooper Antimicrob. Agents Chemother. December 2000 44: 3344-3350; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of an In Vitro-Selected Amoxicillin-Resistant Strain of Helicobacter pylori Cindy R. DeLoney and Neal L. Schiller Antimicrob. Agents Chemother. December 2000 44: 3368-3373; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Two New Mechanisms of Macrolide Resistance in Clinical Strains of Streptococcus pneumoniae from Eastern Europe and North America A. Tait-Kamradt, T. Davies, P. C. Appelbaum, F. Depardieu, P. Courvalin, J. Petitpas, L. Wondrack, A. Walker, M. R. Jacobs, and J. Sutcliffe Antimicrob. Agents Chemother. December 2000 44: 3395-3401; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

High-Level Fluoroquinolone-Resistant Clinical Isolates of Escherichia coli Overproduce Multidrug Efflux Protein AcrA Annarita Mazzariol, Yutaka Tokue, Tiffany M. Kanegawa, Giuseppe Cornaglia, and Hiroshi Nikaido Antimicrob. Agents Chemother. December 2000 44: 3441-3443; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Characterization of a Divergent vanD-Type Resistance Element from the First Glycopeptide-Resistant Strain of Enterococcus faecium Isolated in Brazil Libera M. Dalla Costa, Peter E. Reynolds, Helena A. P. H. M. Souza, Dilair C. Souza, Marie-France I. Palepou, and Neil Woodford Antimicrob. Agents Chemother. December 2000 44: 3444-3446; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Structural and Topological Differences between a Glycopeptide-Intermediate Clinical Strain and Glycopeptide-Susceptible Strains of Staphylococcus aureus Revealed by Atomic Force Microscopy Susan Boyle-Vavra, Jongin Hahm, S. J. Sibener, and Robert S. Daum Antimicrob. Agents Chemother. December 2000 44: 3456-3460; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Use of Molecular Beacons To Detect an Antifolate Resistance-Associated Mutation in Plasmodium falciparum Rémy Durand, Jobin Eslahpazire, Sayeh Jafari, Jean-François Delabre, Anne Marmorat-Khuong, Jean-Philippe di Piazza, and Jacques Le Bras Antimicrob. Agents Chemother. December 2000 44: 3461-3464; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Biologic Response Modifiers:

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Recombinant Murine Granulocyte-Macrophage Colony-Stimulating Factor Modulates the Course of Pulmonary Histoplasmosis in Immunocompetent and Immunodeficient Mice George S. Deepe, Jr. and Reta Gibbons Antimicrob. Agents Chemother. December 2000 44: 3328-3336; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Pharmacology:

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Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance Julie A. Simpson, Emmeline R. Watkins, Ric N. Price, Leon Aarons, Dennis E. Kyle, and Nicholas J. White Antimicrob. Agents Chemother. December 2000 44: 3414-3424; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

Levofloxacin Pharmacokinetics and Serum Bactericidal Activities against Five Enterobacterial Species Hilte F. Geerdes-Fenge, Axel Wiedersich, S. Wagner, Karl-Heinz Lehr, Peter Koeppe, and Hartmut Lode Antimicrob. Agents Chemother. December 2000 44: 3478-3480; [Abstract] [Full Text] [PDF] [Reprints and Permissions]

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Letters:

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Influences of Different Factors on Prevalence of Ciprofloxacin Resistance in Streptococcus pneumoniae in Spain C. García-Rey, L. Aguilar, F. Baquero, and Spanish Surveillance Group for Respiratory Pathogens Antimicrob. Agents Chemother. December 2000 44: 3481-3482; [Full Text] [PDF] [Reprints and Permissions]

Isolation of an SHV-12 -Lactamase-Producing Escherichia coli Strain from a Dog with Recurrent Urinary Tract Infections Tirushet Teshager, Lucas Domínguez, Miguel A. Moreno, Yolanda Saénz, Carmen Torres, and Susana Cardeñosa Antimicrob. Agents Chemother. December 2000 44: 3483-3484; [Full Text] [PDF] [Reprints and Permissions]

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.